Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase

Pharmaceutical Biology

Volumn 52, Issue 1, 2014, Pages 68-73

  Wang, Fang ^a,b   Yan, Juming ^b   Niu, Yanfen ^a   Li, Yan ^b   Lin, Hua ^a   Liu, Xu ^a   Liu, Jikai ^b   Li, Ling ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Active metabolite; AMPK; Insulin resistance; L6 muscle cells; Norathyriol

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MANGIFERIN; NORATHYRIOL; PROTEIN KINASE B; ROSIGLITAZONE;

ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; GLUCOSE INTAKE; GLUCOSE UTILIZATION; IMMUNOBLOTTING; IN VITRO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MYOTUBE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; GLUCOSE; HYPOGLYCEMIC AGENTS; IMMUNOBLOTTING; INSULIN; INSULIN RESISTANCE; MUSCLE FIBERS, SKELETAL; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; THIAZOLIDINEDIONES; UP-REGULATION; XANTHENES; XANTHONES;

EID: 84890491118     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.814691     Document Type: Article

References (41)

1. Aderibigbe AO, Emudianughe TS, Lowal BA. (1999). Antihyper glycemic effect of Mangifera indica in rat. Phytother Res 13:504-7
2. Aderibigbe AO, Emudianughe TS, Lowal BA. (2001). Evaluation of antidiabetic action of Mangifera indica in mice. Phytother Res 15: 456-8
3. Andreu GP, Delgado R, Curti JA, Vercesi AE. (2005). Iron complexing activity of mangiferin, a naturally occurring glucosylxanthone, inhibits mitochondrial lipid peroxidation induced by Fe2+-citrate. Eur J Pharm 513:47-55
4. Bock C, Ternes W. (2010). The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea). Nutr Res 30:348-57
5. Cleasby ME, Dzamko N, Hegarty BD, et al. (2004). Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms. Diabetes 53:3258-66
6. Girón MD, Sevillano N, Salto R, et al. (2009). Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: Role of mangiferin. Clin Nutr 28:565-74
7. Han DD, Chen CJ, Zhang C, et al. (2010). Determination of mangiferin in rat plasma by liquid-liquid extraction with UPLC-MS/MS. J Pharmaceut Biomed 51:260-3
8. Hardie DG. (2004). The AMP-activated protein kinase pathway - New players upstream and downstream. J Cell Sci 117:5479-87
9. Hardie DG, Carling D. (1997). The AMP-activated protein kinase fuel gauge of the mammalian cell? Eur J Biochem 246:259-73
10. Hotamisligil GS. (2006). Inflammation and metabolic disorders. Nature 444:860-7
11. Huang TH, Peng G, Li GQ, et al. (2006). Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: Activation of PPAR-alpha. Toxicol Appl Pharm 210:225-35
12. Hu HG, Wang MJ, Zhao QJ, et al. (2007). Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors. Chem Nat Compd 43:663-6
13. Ichiki H, Miura T, Kubo M, et al. (1998). New antidiabetic compounds, mangiferin and its glucoside. Biol Pharm Bull 21:1389-90
14. Klaman LD, Boss O, Peroni OD, et al. (2000). Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20:5479-89
15. Koistinen HA, Galuska D, Chibalin AV, et al. (2003). 5-Aminoimidazole carboxamide riboside increases glucose transport and cellsurface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 52:1066-72
16. Krook A, Wallberg-Henriksson H, Zierath Jr. (2004). Sending the signal: Molecular mechanism regulating glucose uptake. Med Sci Sport Exer 36:1212-17
17. Li HY, Miyahara T, Tezuka Y, et al. (1998). The effect of kampo formulae on bone resorption in vitro and in vivo. Biol Pharm Bull 21: 1322-6
18. Li Y, Peng G, Li Q, et al. (2004). Salacia oblonga improves cardiac fibrosis and inhibits postprandial hyperglycemia in obese Zucker rats. Life Sci 75:1735-46
19. Liu HH,Wang K, Tang YH, et al. (2011). Structure elucidation of in vivo and in vitro metabolites of mangiferin. J Pharmaceut Biomed 55: 1075-82
20. Mitsumoto Y, Klip A. (1992). Developmental regulation of the subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells. J Biol Chem 267:4957-62
21. Miura T, Ichiki H, Iwamoto N, et al. (2001a). Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside. Biol Pharm Bull 24:1009-11
22. Miura T, Iwamoto N, Kato M, et al. (2001b). The suppressive effect of mangiferin with exercise on blood lipids in type 2 diabetes. Biol Pharm Bull 24:1091-2
23. Moller DE, Flier JS. (1992). Insulin resistance: Mechanisms, syndromes, and implications. New Engl J Med 325:938-42
24. Moller DE. (2001). New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414:821-7
25. Mueller WM, Stanhope KL, Gregoire F, et al. (2000). Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes. Obes Res 8:530-9
26. Muruganandan S, Srinivasan K, Gupta S, et al. (2005). Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharmacol 97:497-501
27. Pardo-Andreu GL, Sanchez-Baldoquin C, Avila-Gonzalez R, et al. (2006). Fe (III) improves antioxidant and cytoprotecting activities of mangiferin. Eur J Pharm 547:31-6
28. Petersen KF, Shulman GI. (2006). New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy. Obesity 14:34S-40S.
29. Sanugul K, Akao T, Li Y, et al. (2005). Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond. Biol Pharm Bull 28: 1672-8
30. Smyth S, Heron A. (2006). Diabetes and obesity: The twin epidemics. Nat Med 12:75-80
31. Taniguchi CM, Emanuelli B, Kahn CR. (2006). Critical nodes in insulin signaling pathways: Insight into insulin action. Nat Rev Mol Cell Biol 7:85-96
32. Tan MJ, Ye JM, Turner N, et al. (2008). Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 15:263-73
33. Walker PS, Ramlals T, Donovan JA, et al. (1989). Insulin and glucosedependent regulation of the glucose transport system in the rat L6 skeletal muscle cell line. J Biol Chem 264:6587-95
34. Wang H, Ye G, Tang YH, et al. (2006). High-performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine. Biomed Chromatogr 20:1304-8
35. Wang H, Ye G, Ma CH, et al. (2007). Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed 45: 793-8
36. Ye JM, Ruderman NB, Kraegen EW. (2005). AMP-activated protein kinase and malonyl-CoA: Targets for treating insulin resistance? Drug Discov Today 2:157-63
37. Yin J, Hu R, Chen M, et al. (2002). Effects of berberine on glucose metabolism in vitro. Metabolism 51:1439-43
38. Yoosook C, Bunyapraphatsara N, Boonyakiat Y, Kantasuk C. (2000). Anti-herpes simplex virus activities of crude water extracts of Thai medicinal plants. Phytomedicine 6:411-19
39. Zhou TT, Zhu ZY, Wang C, et al. (2007). On-line purity monitoring in high-speed counter-current chromatography: Application of HSCCC-HPLC-DAD for the preparation of 5-HMF, neomangiferin and mangiferin from Anemarrhena asphodeloides Bunge. J Pharm Biomed Anal 44:96-100
40. Zierath JR, He L, Guma A ̀, et al. (1996). Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39:1180-9
41. Zuo YQ, Liu WP, Niu YF, et al. (2008). bis(a-Furancarboxylato) oxovanadium(IV) prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes. J Pharm Pharmacol 60: 1335-40