Syntheses and characterization of non-bisphosphonate quinoline derivatives as new FPPS inhibitors

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 3, 2014, Pages 1051-1062

  Liu, Jinggong ^a   Liu, Weilin ^a   Ge, Hu ^a   Gao, Jinbo ^b   He, Qingqing ^a   Su, Lijuan ^a   Xu, Jun ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a   Li, Ding ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Allosteric site; Bisphosphonate; Cancer; Farnesyl pyrophosphate synthase; Quinoline derivative

Indexed keywords

((4 CHLOROBENZO[H]QUINOLIN 2 YL)METHYL)PHOSPHONIC ACID; 2 ((2 ((2 CARBOXYPHENOXY)METHYL)QUINOLIN 4 YL)AMINO)BENZOIC ACID; 2 ((2 (CHLOROMETHYL)QUINOLIN 4 YL)AMINO)BENZOIC ACID; 2 ((2 METHYLBENZO[H]QUINOLIN 4 YL)AMINO)BENZOIC ACID; 2 ((4 CHLOROBENZO[H]QUINOLIN 2 YL)METHOXY)BENZOIC ACID; 2 ((4 CHLOROBENZO[H]QUINOLIN 2 YL)METHYL)MALONIC ACID; 2 ((4 CHLOROQUINOLIN 2 YL)METHOXY)BENZOIC ACID; 3 (4 CHLOROBENZO[H]QUINOLIN 2 YL) 2 PHOSPHONOPROPANOIC ACID; 4 CHLORO 2 ((4 ((4 METHOXYPHENYL)AMINO)BENZO[H]QUINOLIN 2 YL)METHOXY)BENZOIC ACID; 5 ((2 ((2 CARBOXYPHENOXY)METHYL)BENZO[H]QUINOLIN 4 YL)AMINO)ISOPHTHALIC ACID; ANTINEOPLASTIC AGENT; DIETHYL ((4 CHLOROBENZO[H]QUINOLIN 2 YL)METHYL)PHOSPHONATE; DIMETHYL 2 ((4 CHLOROBENZO[H]QUINOLIN 2 YL)METHYL)MALONATE; DIMETHYL 5 ((2 ((2 (ETHOXYCARBONYL)PHENOXY)METHYL)BENZO[H]QUINOLIN 4 YL)AMINO)ISOPHTHALATE; ETHYL 2 ((4 ((2 (METHOXYCARBONYL)PHENYL)AMINO)QUINOLIN 2 YL)METHOXY)BENZOATE; ETHYL 2 ((4 CHLOROBENZO[H]QUINOLIN 2 YL)METHOXY)BENZOATE; ETHYL 2 ((4 CHLOROQUINOLIN 2 YL)METHOXY)BENZOATE; ETHYL 3 (4 CHLOROBENZO[H]QUINOLIN 2 YL) 2(DIETHOXYPHOSPHORYL)PROPANOATE; GERANYLTRANSFERASE; HYDROXYAPATITE; METHYL 2 ((2 (CHLOROMETHYL)QUINOLIN 4 YL)AMINO)BENZOATE; METHYL 2 (2 METHYLBENZO[H]QUINOLIN 4 YLAMINO)BENZOATE; METHYL 4 CHLORO 2 ((4 ((4 METHOXYPHENYL)AMINO)BENZO[H]QUINOLIN 2 YL)METHOXY)BENZOATE; QUINOLINE DERIVATIVE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CANCER CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; FEMALE; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYL-TETRAZOLIUM BROMIDE; ALLOSTERIC SITE; BISPHOSPHONATE; BISPHOSPHONATES; BOVINE SERUM ALBUMIN; BPS; BSA; CANCER; DL-DITHIOTHREITOL; DTT; FARNESYL PYROPHOSPHATE SYNTHASE; FPPS; HAP; HYDROXYAPATITE; MTT; QUINOLINE DERIVATIVE; TRIS; TRIS(HYDROXYMETHYL)AMINOMETHANE;

AMINO ACID SEQUENCE; DIPHOSPHONATES; ENZYME INHIBITORS; GERANYLTRANSTRANSFERASE; IMIDAZOLES; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOPLASMS; QUINOLINES;

EID: 84890463727     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.11.006     Document Type: Article

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