Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an agrc quorum sensing receptor in staphylococcus aureus

Journal of the American Chemical Society

Volumn 135, Issue 49, 2013, Pages 18436-18444

  Tal Gan, Yftah ^a   Ivancic, Monika ^a   Cornilescu, Gabriel ^a   Cornilescu, Claudia C ^a   Blackwell, Helen E ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE SIGNALS; RECEPTOR ACTIVATION; STAPHYLOCOCCUS AUREUS; STRUCTURAL CHARACTERIZATION; STRUCTURAL ELEMENTS; STRUCTURAL FEATURE; STRUCTURAL SUPPORT; TRANSMEMBRANE RECEPTORS;

BACTERIA; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES;

BIOACTIVITY;

AGRC RECEPTOR; MACROCYCLIC COMPOUND; PEPTIDE; RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; HYDROPHOBICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; QUORUM SENSING; RECEPTOR BINDING; STAPHYLOCOCCUS AUREUS;

BACTERIAL PROTEINS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDES; PROTEIN CONFORMATION; PROTEIN KINASES; QUORUM SENSING; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84890452539     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja407533e     Document Type: Article

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