Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus

Molecular Microbiology

Volumn 41, Issue 2, 2001, Pages 503-512

  Mdowell, Philip ^a   Affas, Zina ^a   Reynolds, Caroline ^a   Holden, Matthew T G ^a   Wood, Stewart J ^a   Saint, Sandra ^a   Cockayne, Alan ^a   Hill, Philip J ^a   Dodd, Christine E R ^a   Bycroft, Barrie W ^a   Chan, Weng C ^a   Williams, Paul ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARTIC ACID; DEXTRO AMINO ACID; ENDOTOXIN; ENTEROTOXIN; LACTAM; METHIONINE SULFOXIDE; PHEROMONE; STAPHYLOCOCCAL AUTOINDUCING PEPTIDE; THIOLACTONE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL VIRULENCE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; NONHUMAN; NONVERBAL COMMUNICATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

BACTERIAL PROTEINS; COLONY COUNT, MICROBIAL; CYCLIZATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENES, REPORTER; LACTAMS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOPEPTIDES; OXIDATION-REDUCTION; PHENOTYPE; PHEROMONES; RNA, BACTERIAL; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; VIRULENCE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 0034898219     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02539.x     Document Type: Article

References (39)

1. The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model
2. Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus
3. Synthesis of protected peptide-fragments using substituted triphenyl-methyl resins
4. 15-gastrin 1
5. 2-Chlorotrityl chloride resin - Studies on anchoring of Fmoc-amino acids and peptide cleavage
6. Accessory gene regulator controls Staphylococcus aureus virulence in endophthalmitis
7. Diminished virulence of a sar-lagr- mutant of Staphylococcus aureus in the rabbit model of endocarditis
8. Application of the disulfide trapping approach to explain the antiparallel assembly of dimeric rabbit uteroglobin: A preliminary study using short peptide models
9. Role of the accessory gene regulator (agr) in pathogenesis of staphylococcal osteomyelitis
10. Genetic networks controlling the initiation of sporulation and the development of competence in Bacillus subtilis
11. An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae
12. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus
13. Cell density control of staphylococcal virulence mediated by an octapeptide pheromone
14. Bacterial interference caused by autoinducing peptide variants
15. Complement evasion by bacteria and parasites
16. Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria
17. Population studies of methicillin-resistant and -sensitive Staphylococcus aureus strains reveals a lack of variability in the agrD gene encoding a staphylococcal autoinducer peptide
18. Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus
19. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC
20. Structure - Activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence
21. Identification of Staphylococcus aureus virulence genes in a murine model of bacteraemia using signature-tagged mutagenesis
22. Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus
23. Detection of the response regulator Agra in the cytosolic fraction of Staphylococcus aureus by monoclonal antibodies
24. Transcriptional control of the agr-dependent virulence gene regulator, RNAIII, in Staphylococcus aureus
25. 4I for the reduction of methionine sulfoxide in peptides containing cysteine and cystine
26. Regulation of pathogenicity in Staphylococcus aureus by a peptide-based density-sensing system
27. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule
28. The agr P2 operon: An autocatalytic sensory transduction system in Staphylococcus aureus
29. Plasmids in epidermolytic strains of Staphylococcus aureus
30. Structure of the pheromone peptide of the Staphylococcus epidermidis agr system
31. Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives
32. Pheromone cross-inhibition between Staphylococcus aureus and Staphylococcus epidermidis
33. Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system
34. 4I/TFA: Compatibility with peptides containing cysteine and aromatic amino acids
35. Quorum sensing and the population dependent control of virulence