Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells

British Journal of Cancer

Volumn 109, Issue 12, 2013, Pages 3034-3041

  McCloy, R A ^a   Shelley, E J ^a   Roberts, C G ^a   Boslem, E ^a   Biden, T J ^a,b   Nicholson, R I ^c   Gee, J M ^c   Sutherland, R L ^a,b   Musgrove, E A ^a,b,d   Burgess, A ^a,b   Butt, A J ^a,e  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e National Breast Cancer Centre   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PERSIN; PLANT TOXIN; SMALL INTERFERING RNA; TAMOXIFEN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; RNA INTERFERENCE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENDOPLASMIC RETICULUM STRESS; FATTY ALCOHOLS; FEMALE; HUMANS; MCF-7 CELLS; PLANT EXTRACTS; SIGNAL TRANSDUCTION; TAMOXIFEN;

EID: 84890427408     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2013.693     Document Type: Article

References (31)

1. Ariazi EA, Cunliffe HE, Lewis-Wambi JS, Slifker MJ, Willis AL, Ramos P, Tapia C, Kim HR, Yerrum S, Sharma CG, Nicolas E, Balagurunathan Y, Ross EA, Jordan VC (2011) Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time. PNAS 108(47): 18879-18886.
2. Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ (2011) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (\+)-(R)-persin in human breast cancer cells. Bioorg Med Chem 19(23): 7033-7043.
3. Brüning A, Friese K, Burges A, Mylonas I (2010) Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells. Breast Cancer Res 12(4): R45.
4. Butt AJ, Musgrove EA, Sutherland RL (2007) Live or let die: oestrogen regulation of survival signalling in endocrine response. Breast Cancer Res 9(5): 306.
5. Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, MacLeod JK, Liaw TYE, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL (2006) A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells. Mol Cancer Ther 5(9): 2300-2309.
6. Davies MP, Barraclough DL, Stewart C, Joyce KA, Eccles RM, Barraclough R, Rudland PS, Sibson DR (2008) Expression and splicing of the unfolded protein response gene XBP-1 are significantly associated with clinical outcome of endocrine-treated breast cancer. Int J Cancer 123(1): 85-88.
7. Di Fazio P, Ocker M, Montalbano R (2012) New drugs, old fashioned ways: ER stress induced cell death. Curr Pharm Biotechnol 13(11): 2228-2234.
8. Fernandez PM, Tabbara SO, Jacobs LK, Manning FCR, Tsangaris TN, Schwartz AM, Kennedy KA, Patierno SR (2000) Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res Treat 59: 15-26.
9. Gomez BP, Riggins RB, Shajahan AN, Klimach U, Wang A, Crawford AC, Zhu Y, Zwart A, Wang M, Clarke R (2007) Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines. FASEB J 21(14): 4013-4027.
10. Gu Z, Lee RY, Skaar TC, Bouker KB, Welch JN, Lu J, Liu A, Zhu Y, Davis N, Leonessa F, Brünner N, Wang Y, Clarke R (2002) Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182, 780). Cancer Res 62(12): 3428-3437.
11. Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M (2004) Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol 165(3): 347-356.
12. Hu XF, Veroni M, De Luise M, Wakeling A, Sutherland R, Watts CK, Zalcberg JR (1993) Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182, 780. Int J Cancer 55(5): 873-876.
13. Ip C, Dong Y, Ip MM, Banni S, Carta G, Angioni E, Murru E, Spada S, Melis MP, Saebo A (2002) Conjugated linoleic acid isomers and mammary cancer prevention. Nutr Cancer 43: 52-58.
14. Kenny FS, Pinder SE, Ellis IO, Gee JM, Nicholson RI, Bryce RP, Robertson JFR (2000) Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. Int J Cancer 85: 643-648.
15. Kim I, Xu W, Reed JC (2008) Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 7(12): 1013-1030.
16. Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE, Nicholson RI (2003) Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 144: 1032-1044.
17. Lee E, Nichols P, Spicer D, Groshen S, Yu MC, Lee AS (2006) GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res 66: 7849-7853.
18. Liao P-C, Tan S-K, Lieu C-H, Jung H-K (2008) Involvement of endoplasmic reticulum in paclitaxel-induced apoptosis. J Cell Biochem 104: 1509-1523.
19. Liu JJ, Lin M, Yu JY, Liu B, Bao JK (2011) Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Lett 300(2): 105-114.
20. Moenner M, Pluquet O, Bouchecareilh M, Chevet E (2007) Integrated endoplasmic reticulum stress responses in cancer. Cancer Res 67(22): 10631-10634.
21. Musgrove EA, Sutherland RL (2009) Biological determinants of endocrine resistance in breast cancer. Nat Rev Cancer 9(9): 631-643.
22. Nishino H, Murakoshi M, Mou XY, Wada S, Masuda M, Ohsaka Y, Satomi Y, Jinno K (2005) Cancer prevention by phytochemicals. Oncology 69: 38-40.
23. Oelrichs PB, Ng JC, Seawright AA, Ward A, Schaffeler L, MacLeod JK (1995) Isolation and identification of a compound from avocado (Persea americana) leaves which causes necrosis of the acinar epithelium of the lactating mammary gland and the myocardium. Nat Toxins 3: 344-349.
24. Oyadomari S, Mori M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11(4): 381-389.
25. Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND, Hughes PD, Michalak EM, McKimm-Breschkin J, Motoyama N, Gotoh T, Akira S, Bouillet P, Strasser A (2007) ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129(7): 1337-1349.
26. Reed JC (2002) Apoptosis-based therapies. Nat Rev Drug Discov 1(2): 111-121.
27. Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ (2007) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism. Mol Cancer Ther 6(10): 2777-2785.
28. Schönthal AH (2009) Endoplasmic reticulum stress and autophagy as targets for cancer therapy. Cancer Lett 275(2): 163-169.
29. Scriven P, Coulson S, Haines R, Balasubramanian S, Cross S, Wyld L (2009) Activation and clinical significance of the unfolded protein response in breast cancer. Br J Cancer 101(10): 1692-1698.
30. Tiwary R, Yu W, Degraffenried LA, Sanders BG, Kline K (2011) Targeting cholesterol-rich microdomains to circumvent tamoxifen-resistant breast cancer. Breast Cancer Res 13(6): R120.
31. Woodcock J (2006) Sphingosine and ceramide signalling in apoptosis. IUBMB Life 58(8): 462-466.