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Volumn 8, Issue 5, 2014, Pages 573-582

In vitro toxicity assessment of silver nanoparticles in the presence of phenolic compounds-preventive agents against the harmful effect?

Author keywords

Caco 2 cells; Cytotoxicity; Oxidative stress; Phenolic compounds; Silver ion; Silver nanoparticles; Tight junctions

Indexed keywords

KAEMPFEROL; LUCIFER YELLOW; OCCLUDIN; PHENOL DERIVATIVE; PROTEIN ZO1; QUERCETIN; RESVERATROL; SILVER NANOPARTICLE;

EID: 84890403940     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2013.812258     Document Type: Article
Times cited : (73)

References (61)
  • 1
    • 44449100218 scopus 로고    scopus 로고
    • Quercetin enhances epithelial barrier function and increases claudin-4 expression in caco-2 cells
    • Amasheh M, Schlichter S, Amasheh S, Mankertz J, Zeitz M, Fromm M, et al. 2008. Quercetin enhances epithelial barrier function and increases claudin-4 expression in caco-2 cells. J Nutr 138 (6):1067-1073.
    • (2008) J Nutr , vol.138 , Issue.6 , pp. 1067-1073
    • Amasheh, M.1    Schlichter, S.2    Amasheh, S.3    Mankertz, J.4    Zeitz, M.5    Fromm, M.6
  • 2
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • Artursson P, Karlson J. 1991. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 175(3):880-885.
    • (1991) Biochem Biophys Res Commun , vol.175 , Issue.3 , pp. 880-885
    • Artursson, P.1    Karlson, J.2
  • 4
    • 0141863402 scopus 로고    scopus 로고
    • Overview of dietary flavonoids: Nomenclature, occurrence and intake
    • Beecher G. 2003. Overview of dietary flavonoids: Nomenclature, occurrence and intake. J Nutr 133:3248S-3254S.
    • (2003) J Nutr , vol.133
    • Beecher, G.1
  • 6
    • 44449144047 scopus 로고    scopus 로고
    • Nanoparticle silver released into water from commercially available sock fabrics
    • Benn TM, Westerhoff P. 2008. Nanoparticle silver released into water from commercially available sock fabrics. Environ Sci Technol 42:4133-4139.
    • (2008) Environ Sci Technol , vol.42 , pp. 4133-4139
    • Benn, T.M.1    Westerhoff, P.2
  • 8
    • 80051532158 scopus 로고    scopus 로고
    • Characterization of translocation of silver nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model
    • Bouwmeester H, Poortman J, Peters RJ, Wijma E, Kramer E, Makama S, et al. 2011. Characterization of translocation of silver nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model. ACS Nano 5 (5):4091-4103.
    • (2011) ACS Nano , vol.5 , Issue.5 , pp. 4091-4103
    • Bouwmeester, H.1    Poortman, J.2    Peters, R.J.3    Wijma, E.4    Kramer, E.5    Makama, S.6
  • 9
    • 27944489615 scopus 로고    scopus 로고
    • In vitro cytotoxicity of nanoparticles in mammalian germline stem cells
    • Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. 2005. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci 88:412-419.
    • (2005) Toxicol Sci , vol.88 , pp. 412-419
    • Braydich-Stolle, L.1    Hussain, S.2    Schlager, J.J.3    Hofmann, M.C.4
  • 10
    • 33846432736 scopus 로고    scopus 로고
    • A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models
    • Burd A, Kwok CH, Hung SC, Chan HS, Gu H, Lam WK, et al. 2007. A comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models. Wound Repair Regen 15:94-104.
    • (2007) Wound Repair Regen , vol.15 , pp. 94-104
    • Burd, A.1    Kwok, C.H.2    Hung, S.C.3    Chan, H.S.4    Gu, H.5    Lam, W.K.6
  • 11
    • 85123316636 scopus 로고    scopus 로고
    • Nanomaterials and nanoparticles: Sources and toxicity
    • Buzea C, Pacheco I, Robbie K. 2007. Nanomaterials and nanoparticles: Sources and toxicity. Biointerphases 4:MR17-MR71.
    • (2007) Biointerphases , vol.4
    • Buzea, C.1    Pacheco, I.2    Robbie, K.3
  • 12
    • 75549086308 scopus 로고    scopus 로고
    • The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake
    • Cao J, Zhang Y, Chen W, Zhao X. 2010. The relationship between fasting plasma concentrations of selected flavonoids and their ordinary dietary intake. Br J Nutr 103:249-255.
    • (2010) Br J Nutr , vol.103 , pp. 249-255
    • Cao, J.1    Zhang, Y.2    Chen, W.3    Zhao, X.4
  • 13
    • 55949113520 scopus 로고    scopus 로고
    • Unique cellular interaction of silver nanoparticles: Size-dependent generation of reactive oxygen species
    • Carlson C, Hussain SM, Schrand AM, Braydich-Stolle LK, Hess KL, Jones RL, et al. 2008. Unique cellular interaction of silver nanoparticles: Size-dependent generation of reactive oxygen species. J Phys Chem B 112(43):13608-13619.
    • (2008) J Phys Chem B , vol.112 , Issue.43 , pp. 13608-13619
    • Carlson, C.1    Hussain, S.M.2    Schrand, A.M.3    Braydich-Stolle, L.K.4    Hess, K.L.5    Jones, R.L.6
  • 14
    • 0034734982 scopus 로고    scopus 로고
    • Lectin-mediatedmucosal delivery of drugs and microparticles
    • ClarkMA, Hirst BH, JepsonMA. 2000. Lectin-mediatedmucosal delivery of drugs and microparticles. Adv Drug Deliv Rev 43:207-223.
    • (2000) Adv Drug Deliv Rev , vol.43 , pp. 207-223
    • Clark, M.A.1    Hirst, B.H.2    Jepson, M.A.3
  • 16
    • 0030894188 scopus 로고    scopus 로고
    • Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets
    • de Vries JH, Janssen PL, Hollman PC, van Staveren WA, Katan MB. 1997. Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets. Cancer Lett 114 (1-2):141-144.
    • (1997) Cancer Lett , vol.114 , Issue.1-2 , pp. 141-144
    • De Vries, J.H.1    Janssen, P.L.2    Hollman, P.C.3    Van Staveren, W.A.4    Katan, M.B.5
  • 17
    • 33947265152 scopus 로고    scopus 로고
    • An improved in vitro model of human intestinal follicle-Associated epithelium to study nanoparticle transport by M cells
    • des Rieux A, Fievez V, Théate I, Mast J, Préat V, Schneider YJ. 2007. An improved in vitro model of human intestinal follicle-Associated epithelium to study nanoparticle transport by M cells. Eur J Pharm Sci 30:380-391.
    • (2007) Eur J Pharm Sci , vol.30 , pp. 380-391
    • Des Rieux, A.1    Fievez, V.2    Théate, I.3    Mast, J.4    Préat, V.5    Schneider, Y.J.6
  • 18
    • 20744454954 scopus 로고    scopus 로고
    • Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium
    • des Rieux A, Ragnarsson EG, Gullberg E, Preat V, Schneider YJ, Artursson P. 2005. Transport of nanoparticles across an in vitro model of the human intestinal follicle associated epithelium. Eur J Pharm Sci 25(4-5):455-465.
    • (2005) Eur J Pharm Sci , vol.25 , Issue.4-5 , pp. 455-465
    • Des Rieux, A.1    Ragnarsson, E.G.2    Gullberg, E.3    Preat, V.4    Schneider, Y.J.5    Artursson, P.6
  • 19
  • 20
    • 70350747587 scopus 로고    scopus 로고
    • The behavior of silver nanotextiles during washing
    • Geranio L, Heuberger M, Nowack B. 2009. The behavior of silver nanotextiles during washing. Environ Sci Technol 4(21):8113-8118.
    • (2009) Environ Sci Technol , vol.4 , Issue.21 , pp. 8113-8118
    • Geranio, L.1    Heuberger, M.2    Nowack, B.3
  • 21
    • 73049096477 scopus 로고    scopus 로고
    • Antioxidant properties of resveratrol: A structure-Activity insight
    • Gülçin I. 2010. Antioxidant properties of resveratrol: A structure-Activity insight. Innovative Food Sci Emerg Technol 11(1):210-218.
    • (2010) Innovative Food Sci Emerg Technol , vol.11 , Issue.1 , pp. 210-218
    • Gülçin, I.1
  • 22
    • 34548812546 scopus 로고    scopus 로고
    • A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
    • Harwood M, Danielewska-Nikiel B, Borzelleca JF, Flamm GW, Williams GM, Lines TC. 2007. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 45:2179-2205.
    • (2007) Food Chem Toxicol , vol.45 , pp. 2179-2205
    • Harwood, M.1    Danielewska-Nikiel, B.2    Borzelleca, J.F.3    Flamm, G.W.4    Williams, G.M.5    Lines, T.C.6
  • 23
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands
    • Hertog MGL, Hollman PCH, Katan MB, Kromhout D. 1993. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 20:21-29.
    • (1993) Nutr Cancer , vol.20 , pp. 21-29
    • Hertog, M.G.L.1    Hollman, P.C.H.2    Katan, M.B.3    Kromhout, D.4
  • 24
    • 76149133133 scopus 로고    scopus 로고
    • Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: A kinetic and mechanistic study
    • Ho C, Yau S, Lok C, So M, Che C. 2010. Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: A kinetic and mechanistic study. Chem Asian J 5:285-293.
    • (2010) Chem Asian J , vol.5 , pp. 285-293
    • Ho, C.1    Yau, S.2    Lok, C.3    So, M.4    Che, C.5
  • 27
    • 68049090816 scopus 로고    scopus 로고
    • Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells
    • Kim S, Choi JE, Choi J, Chang K-H, Park K, Yi J, et al. 2009. Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro 23(6):1076-1084.
    • (2009) Toxicol In Vitro , vol.23 , Issue.6 , pp. 1076-1084
    • Kim, S.1    Choi, J.E.2    Choi, J.3    Chang, K.-H.4    Park, K.5    Yi, J.6
  • 29
    • 78149408398 scopus 로고    scopus 로고
    • Facile syn thesis, stabilization, and anti-bacterial performance of discrete Ag nanoparticles using Medicago sativa seed exudates
    • Lukman AI, Gong B, Marjo CE, Roessner U, Harris AT. 2011. Facile synthesis, stabilization, and anti-bacterial performance of discrete Ag nanoparticles using Medicago sativa seed exudates. J Colloid Interface Sci 353:433-444.
    • (2011) J Colloid Interface Sci , vol.353 , pp. 433-444
    • Lukman, A.I.1    Gong, B.2    Marjo, C.E.3    Roessner, U.4    Harris, A.T.5
  • 30
    • 55749091647 scopus 로고    scopus 로고
    • Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
    • Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson KA. 2008. Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc Natl Acad Sci USA 105:14265-14270.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14265-14270
    • Lundqvist, M.1    Stigler, J.2    Elia, G.3    Lynch, I.4    Cedervall, T.5    Dawson, K.A.6
  • 31
    • 35349010059 scopus 로고    scopus 로고
    • The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st Century
    • Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA. 2007. The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st Century. J Colloid Interface Sci 134-135:167-174.
    • (2007) J Colloid Interface Sci , vol.134-135 , pp. 167-174
    • Lynch, I.1    Cedervall, T.2    Lundqvist, M.3    Cabaleiro-Lago, C.4    Linse, S.5    Dawson, K.A.6
  • 33
    • 0019275289 scopus 로고
    • Experimental modulation of occludin junctions in a cultured transporting epithelium
    • Martinez-Palomo A, Meza I, Beaty G, Cereijido M. 1980. Experimental modulation of occludin junctions in a cultured transporting epithelium. J Cell Biol 87:736-745.
    • (1980) J Cell Biol , vol.87 , pp. 736-745
    • Martinez-Palomo, A.1    Meza, I.2    Beaty, G.3    Cereijido, M.4
  • 34
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton E Jr, Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton Jr., E.1    Kandaswami, C.2    Theoharides, T.C.3
  • 36
    • 0002551922 scopus 로고
    • In: Huang MT, Ho CT, Lee CY, editor. Phenolic compounds in food and their effects on health II. Antioxidants & cancer prevention. American Chemical Society Series 507. Washington, DC: American Chemical Society.
    • Pratt DE. 1992. Natural antioxidants from plant material. In: Huang MT, Ho CT, Lee CY, editor. Phenolic compounds in food and their effects on health II. Antioxidants & cancer prevention. American Chemical Society Series 507. Washington, DC: American Chemical Society. pp 54-71.
    • (1992) Natural antioxidants from plant material , pp. 54-71
    • Pratt, D.E.1
  • 37
    • 0036901407 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-caderinbeta-catenin coplexes from the cytoskeleton by oxidative stress
    • Rao RK, Basuroy S, Rao VU, Kamaky KJ Jr, Gupta A. 2002. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-caderinbeta-catenin coplexes from the cytoskeleton by oxidative stress. Biochem J 368(Pt 2):471-481.
    • (2002) Biochem J , vol.368 , Issue.PART 2 , pp. 471-481
    • Rao, R.K.1    Basuroy, S.2    Rao, V.U.3    Kamaky Jr., K.J.4    Gupta, A.5
  • 38
    • 77649212361 scopus 로고    scopus 로고
    • Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro
    • Samberg ME, Oldenburg SJ, Monteiro-Riviere NA. 2010. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ Health Perspect 118(3):407-413.
    • (2010) Environ Health Perspect , vol.118 , Issue.3 , pp. 407-413
    • Samberg, M.E.1    Oldenburg, S.J.2    Monteiro-Riviere, N.A.3
  • 40
    • 24944439903 scopus 로고    scopus 로고
    • Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations
    • Sergent T, Garsou S, Schaut A, De Saeger S, Pussemier L, Van Peteghem C, et al. 2005. Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations. Toxicol Lett 159(1):60-70.
    • (2005) Toxicol Lett , vol.159 , Issue.1 , pp. 60-70
    • Sergent, T.1    Garsou, S.2    Schaut, A.3    De Saeger, S.4    Pussemier, L.5    Van Peteghem, C.6
  • 41
    • 1542677112 scopus 로고    scopus 로고
    • Role of phosphaditylinositol 3-kinase in oxidative stress-induced disruption of tight junctions
    • Sheth P, Basuroy S, Li C, Naren AP, Rao RK. 2003. Role of phosphaditylinositol 3-kinase in oxidative stress-induced disruption of tight junctions. J Biol Chem 278:49239-49245.
    • (2003) J Biol Chem , vol.278 , pp. 49239-49245
    • Sheth, P.1    Basuroy, S.2    Li, C.3    Naren, A.P.4    Rao, R.K.5
  • 42
    • 22844450866 scopus 로고    scopus 로고
    • Resveratrol as an anticancer nutrient: Molecular basis, open questions and promises
    • Signorelli P, Ghidoni R. 2005. Resveratrol as an anticancer nutrient: Molecular basis, open questions and promises. J Nutr Biochem 16 (8):449-466.
    • (2005) J Nutr Biochem , vol.16 , Issue.8 , pp. 449-466
    • Signorelli, P.1    Ghidoni, R.2
  • 43
    • 77955662391 scopus 로고    scopus 로고
    • Efeito de flavoná ides no stresse oxidante e foto-oxidante no eritrá cito humano
    • Silva J, Beirão T, Filipe P, Fernandes A. 2006. Efeito de flavoná ides no stresse oxidante e foto-oxidante no eritrá cito humano. Boletim da SPHM 21(1):6-29.
    • (2006) Boletim da SPHM , vol.21 , Issue.1 , pp. 6-29
    • Silva, J.1    Beirão, T.2    Filipe, P.3    Fernandes, A.4
  • 44
    • 84864435661 scopus 로고    scopus 로고
    • Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles
    • Singh RP, Ramarao P. 2012. Cellular uptake, intracellular trafficking and cytotoxicity of silver nanoparticles. Toxicol Lett 213(2):249-259.
    • (2012) Toxicol Lett , vol.213 , Issue.2 , pp. 249-259
    • Singh, R.P.1    Ramarao, P.2
  • 46
    • 77954607451 scopus 로고    scopus 로고
    • Antibacterial activity of nanosilver ions and particles
    • Sotiriou GA, Pratsinis SE. 2010. Antibacterial activity of nanosilver ions and particles. Environ Sci Technol 44:5649-5654.
    • (2010) Environ Sci Technol , vol.44 , pp. 5649-5654
    • Sotiriou, G.A.1    Pratsinis, S.E.2
  • 47
    • 65349095529 scopus 로고    scopus 로고
    • Quercetin enhances intestinal barrier function through the assembly of zonnula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells
    • Suzuki T, Hara H. 2009. Quercetin enhances intestinal barrier function through the assembly of zonnula occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr 139(5):965-974.
    • (2009) J Nutr , vol.139 , Issue.5 , pp. 965-974
    • Suzuki, T.1    Hara, H.2
  • 48
    • 79954604708 scopus 로고    scopus 로고
    • Role of flavonoids in intestinal tight junction regulation
    • Suzuki T, Hara H. 2011. Role of flavonoids in intestinal tight junction regulation. J Nutr Biochem 22(5):401-408.
    • (2011) J Nutr Biochem , vol.22 , Issue.5 , pp. 401-408
    • Suzuki, T.1    Hara, H.2
  • 49
    • 78650452784 scopus 로고    scopus 로고
    • Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells
    • Suzuki T, Tanabe S, Hara H. 2011. Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells. J Nutr 141(1):87-94.
    • (2011) J Nutr , vol.141 , Issue.1 , pp. 87-94
    • Suzuki, T.1    Tanabe, S.2    Hara, H.3
  • 50
    • 84858415983 scopus 로고    scopus 로고
    • Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum
    • Tatsimo SJ, Tamokou Jde D, Havyarimana L, Csupor D, Forgo P, Hohmann J, et al. 2012. Antimicrobial and antioxidant activity of kaempferol rhamnoside derivatives from Bryophyllum pinnatum. BMC Res Notes 5:158.
    • (2012) BMC Res Notes , vol.5 , pp. 158
    • Tatsimo, S.J.1    Tamokou Jde, D.2    Havyarimana, L.3    Csupor, D.4    Forgo, P.5    Hohmann, J.6
  • 51
    • 77958459116 scopus 로고    scopus 로고
    • Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells
    • Trickler WJ, Lantz SM, Murdock RC, Schrand AM, Robinson BL, Newport GD, et al. 2010. Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells. Toxicol Sci 118(1):160-170.
    • (2010) Toxicol Sci , vol.118 , Issue.1 , pp. 160-170
    • Trickler, W.J.1    Lantz, S.M.2    Murdock, R.C.3    Schrand, A.M.4    Robinson, B.L.5    Newport, G.D.6
  • 54
    • 84865588812 scopus 로고    scopus 로고
    • Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure
    • van der Zande M, Vandebriel RJ, Van Doren E, Kramer E, Herrera Rivera Z, Serrano-Rojero CS, et al. 2012. Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano 6(8):7427-7442.
    • (2012) ACS Nano , vol.6 , Issue.8 , pp. 7427-7442
    • Van Der Zande, M.1    Vandebriel, R.J.2    Van Doren, E.3    Kramer, E.4    Herrera Rivera, Z.5    Serrano-Rojero, C.S.6
  • 55
    • 0037193067 scopus 로고    scopus 로고
    • Direct liquid chromatography analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection
    • Vitrac X, Moni JP, Vercauteren J, Deffieux G, Mérillon JM. 2002. Direct liquid chromatography analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection. Anal Chim Acta 458:103-110.
    • (2002) Anal Chim Acta , vol.458 , pp. 103-110
    • Vitrac, X.1    Moni, J.P.2    Vercauteren, J.3    Deffieux, G.4    Mérillon, J.M.5
  • 56
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    • Wang H, Joseph JA. 1999. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616.
    • (1999) Free Radic Biol Med , vol.27 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2
  • 57
    • 0034306505 scopus 로고    scopus 로고
    • Enhancing paracellular permeability by modulating epithelial tight junctions
    • Ward PD, Tippin TK, Thakker DR. 2000. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technol Today 3(10):346-358.
    • (2000) Pharm Sci Technol Today , vol.3 , Issue.10 , pp. 346-358
    • Ward, P.D.1    Tippin, T.K.2    Thakker, D.R.3
  • 58
    • 0034485643 scopus 로고    scopus 로고
    • Modulation of intestinal permeability: A novel and innovative approach for the oral delivery of drugs, macromolecules and antigens
    • Watts TL, Fasano A. 2000. Modulation of intestinal permeability: A novel and innovative approach for the oral delivery of drugs, macromolecules and antigens. Biotechnol Genet Eng Rev 17:433-453.
    • (2000) Biotechnol Genet Eng Rev , vol.17 , pp. 433-453
    • Watts, T.L.1    Fasano, A.2


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