Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor

Journal of Immunology

Volumn 191, Issue 12, 2013, Pages 5807-5810

  Cummings, Hannah E ^a,b,c   Liu, Tao ^a,b,c   Feng, Chunli ^a,b   Laidlaw, Tanya M ^a,b,c   Conley, Pamela B ^c   Kanaoka, Yoshihide ^a,b,c   Boyce, Joshua A ^a,b,c,d  

^a Jeff and Penny Vinik Center for Allergic Disease Research   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Portola Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; CHEMOKINE; CXCL4 CHEMOKINE; CYSTEINYL TYPE 1 LEUKOTRIENE RECEPTOR; CYSTEINYL TYPE 2 LEUKOTRIENE RECEPTOR; LEUKOTRIENE C4; LEUKOTRIENE RECEPTOR; PADGEM PROTEIN; PROTEIN GPR99; PURINERGIC P2Y12 RECEPTOR; RECEPTOR PROTEIN; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GRANULOCYTE; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE RICH PLASMA;

EID: 84890389854     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302187     Document Type: Article

References (37)

1. Drazen, J. M., and E. Israel. 1995. Treatment of chronic stable asthma with drugs active on the 5-lipoxygenase pathway. Int. Arch. Allergy Immunol. 107: 319-320.
2. Dixon, R. A., R. E. Diehl, E. Opas, E. Rands, P. J. Vickers, J. F. Evans, J. W. Gillard, and D. K. Miller. 1990. Requirement of a 5-lipoxygenase- activating protein for leukotriene synthesis. Nature 343: 282-284.
3. Lam, B. K., J. F. Penrose, G. J. Freeman, and K. F. Austen. 1994. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc. Natl. Acad. Sci. USA 91: 7663-7667.
4. Han, B., G. Luo, Z. Z. Shi, R. Barrios, D. Atwood, W. Liu, G. M. Habib, R. N. Sifers, D. B. Corry, and M. W. Lieberman. 2002. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Am. J. Pathol. 161: 481-490.
5. Lee, C. W., R. A. Lewis, E. J. Corey, and K. F. Austen. 1983. Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes. Immunology 48: 27-35.
6. Lynch, K. R., G. P. O'Neill, Q. Liu, D. S. Im, N. Sawyer, K. M. Metters, N. Coulombe, M. Abramovitz, D. J. Figueroa, Z. Zeng, et al. 1999. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399: 789-793.
7. Mollerup, J., S. T. Jørgensen, C. Hougaard, and E. K. Hoffmann. 2001. Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes. Biochim. Biophys. Acta 1517: 455-459.
8. Hui, Y., G. Yang, H. Galczenski, D. J. Figueroa, C. P. Austin, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and C. D. Funk. 2001. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. J. Biol. Chem. 276: 47489-47495.
9. Heise, C. E., B. F. O'Dowd, D. J. Figueroa, N. Sawyer, T. Nguyen, D. S. Im, R. Stocco, J. N. Bellefeuille, M. Abramovitz, R. Cheng, et al. 2000. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275: 30531-30536.
10. Kanaoka, Y., A. Maekawa, and K. F. Austen. 2013. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J. Biol. Chem. 288: 10967-10972.
11. Knorr, B., J. Matz, J. A. Bernstein, H. Nguyen, B. C. Seidenberg, T. F. Reiss, and A. Becker; Pediatric Montelukast Study Group. 1998. Montelukast for chronic asthma in 6- to 14-year-old children: a randomized, double-blind trial. JAMA 279: 1181-1186.
12. Barrett, N. A., J. M. Fernandez, A. Maekawa, W. Xing, L. Li, M. W. Parsons, K. F. Austen, and Y. Kanaoka. 2012. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J. Immunol. 189: 4556-4565.
13. Laidlaw, T. M., M. S. Kidder, N. Bhattacharyya, W. Xing, S. Shen, G. L. Milne, M. C. Castells, H. Chhay, and J. A. Boyce. 2012. Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes. Blood 119: 3790-3798.
14. Sarma, J., C. A. Laan, S. Alam, A. Jha, K. A. Fox, and I. Dransfield. 2002. Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation 105: 2166-2171.
15. Pitchford, S. C., S. Momi, S. Giannini, L. Casali, D. Spina, C. P. Page, and P. Gresele. 2005. Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation. Blood 105: 2074-2081.
16. Antoine, C., R. C. Murphy, P. M. Henson, and J. Maclouf. 1992. Time-dependent utilization of platelet arachidonic acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations. Biochim. Biophys. Acta 1128: 139-146.
17. Hasegawa, S., T. Ichiyama, K. Hashimoto, Y. Suzuki, R. Hirano, R. Fukano, and S. Furukawa. 2010. Functional expression of cysteinyl leukotriene receptors on human platelets. Platelets 21: 253-259.
18. Thomas, D. W., and T. M. Coffman. 1998. A genetic approach for studying the role of thromboxane A2 in the kidney. Kidney Int. Suppl. 67: S84-S87.
19. Hollopeter, G., H. M. Jantzen, D. Vincent, G. Li, L. England, V. Ramakrishnan, R. B. Yang, P. Nurden, A. Nurden, D. Julius, and P. B. Conley. 2001. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409: 202-207.
20. Beller, T. C., A. Maekawa, D. S. Friend, K. F. Austen, and Y. Kanaoka. 2004. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J. Biol. Chem. 279: 46129-46134.
21. Maekawa, A., Y. Kanaoka, B. K. Lam, and K. F. Austen. 2001. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc. Natl. Acad. Sci. USA 98: 2256-2261.
22. Paruchuri, S., H. Tashimo, C. Feng, A. Maekawa, W. Xing, Y. Jiang, Y. Kanaoka, P. Conley, and J. A. Boyce. 2009. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J. Exp. Med. 206: 2543-2555.
23. Liu, T., T. M. Laidlaw, H. R. Katz, and J. A. Boyce. 2013. Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc. Natl. Acad. Sci. USA 110: 16987-16992.
24. Kanaoka, Y., and J. A. Boyce. 2004. Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses. J. Immunol. 173: 1503-1510.
25. Maugeri, N., V. Evangelista, A. Celardo, G. Dell'Elba, N. Martelli, P. Piccardoni, G. de Gaetano, and C. Cerletti. 1994. Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2 and leukotriene C4 cooperative synthesis. Thromb. Haemost. 72: 450-456.
26. Gauvreau, G. M., K. N. Parameswaran, R. M. Watson, and P. M. O'Byrne. 2001. Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. Am. J. Respir. Crit. Care Med. 164: 1495-1500.
27. Drazen, J. M. 1986. Inhalation challenge with sulfidopeptide leukotrienes in human subjects. Chest 89: 414-419.
28. Dees, C., A. Akhmetshina, P. Zerr, N. Reich, K. Palumbo, A. Horn, A. Jüngel, C. Beyer, G. Krönke, J. Zwerina, et al. 2011. Platelet-derived serotonin links vascular disease and tissue fibrosis. J. Exp. Med. 208: 961-972.
29. Johansson, M. W., S. T. Han, K. A. Gunderson, W. W. Busse, N. N. Jarjour, and D. F. Mosher. 2012. Platelet activation, P-selectin, and eosinophil b1-integrin activation in asthma. Am. J. Respir. Crit. Care Med. 185: 498-507.
30. Jiang, Y., L. A. Borrelli, Y. Kanaoka, B. J. Bacskai, and J. A. Boyce. 2007. CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Blood 110: 3263-3270.
31. Zhang, F. L., L. Luo, E. Gustafson, J. Lachowicz, M. Smith, X. Qiao, Y. H. Liu, G. Chen, B. Pramanik, T. M. Laz, et al. 2001. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. J. Biol. Chem. 276: 8608-8615.
32. Nonaka, Y., T. Hiramoto, and N. Fujita. 2005. Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in vitro methods. Biochem. Biophys. Res. Commun. 337: 281-288.
33. Momi, S., S. C. Pitchford, P. F. Alberti, P. Minuz, P. Del Soldato, and P. Gresele. 2005. Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice. Thromb. Haemost. 93: 535-543.
34. Bubel, S., D. Wilhelm, M. Entelmann, H. Kirchner, and H. Klüter. 1996. Chemokines in stored platelet concentrates. Transfusion 36: 445-449.
35. Adamjee, J., Y. J. Suh, H. S. Park, J. H. Choi, J. F. Penrose, B. K. Lam, K. F. Austen, A. M. Cazaly, S. J. Wilson, and A. P. Sampson. 2006. Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. J. Pathol. 209: 392-399.
36. Tapp, L. D., E. Shantsila, B. J. Wrigley, B. Pamukcu, and G. Y. Lip. 2012. The CD14++CD16+ monocyte subset and monocyte-platelet interactions in patients with ST-elevation myocardial infarction. J. Thromb. Haemost. 10: 1231-1241.
37. Franks, Z. G., R. A. Campbell, A. S. Weyrich, and M. T. Rondina. 2010. Plateletleukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. Ann. N. Y. Acad. Sci. 1207: 11-17.