CD4+ T cell-receptor repertoire diversity is compromised in the spleen but not in the bone marrow of aged mice due to private and sporadic clonal expansions

Frontiers in Immunology

Volumn 4, Issue NOV, 2013, Pages

  Shifrut, Eric ^a   Baruch, Kuti ^a   Gal, Hilah ^a   Ndifon, Wilfred ^a   Deczkowska, Aleksandra ^a   Schwartz, Michal ^a   Friedman, Nir ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Aging; Clonal dominance; High throughput sequencing; Immune niche; TCR repertoire; TCR seq

Indexed keywords

T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CELL ISOLATION; COMPARATIVE STUDY; FLOW CYTOMETRY; HIGH THROUGHPUT SEQUENCING; IMMUNE SYSTEM; MALE; MICROENVIRONMENT; MOUSE; NONHUMAN; SPLEEN;

EID: 84890382431     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00379     Document Type: Article

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