Modulation of NF-κB and Nrf2 control of inflammatory responses in FHs 74 int cell line is tocopherol isoform-specific

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 305, Issue 12, 2013, Pages

  Elisia, Ingrid ^a   Kitts, David D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

IL 8; Inflammation; NF B; Nrf2; Tocopherol

Indexed keywords

CYTOKINE; DELTA TOCOPHEROL; GAMMA INTERFERON; GAMMA TOCOPHEROL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; PHORBOL 12 ACETATE 13 MYRISTATE; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 2; PROSTAGLANDIN SYNTHASE; TOCOPHEROL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL LINE; CELL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; FETAL DERIVED INTESTINAL CELL; FETUS; GENE TARGETING; HUMAN; HUMAN CELL; INFLAMMATION; INTESTINE CELL; MEDIATOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

IL-8; INFLAMMATION; NF-ΚB; NRF2; TOCOPHEROL;

ANTIOXIDANTS; CELLS, CULTURED; FETAL RESEARCH; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; INTESTINE, SMALL; NF-E2-RELATED FACTOR 2; NF-KAPPA B; SIGNAL TRANSDUCTION; TOCOPHEROLS;

EID: 84890382027     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00269.2013     Document Type: Article

References (57)

1. Anderson SA, Chinn HI, Fisher KD. History and current status of infant formulas. Am J Clin Nutr 35: 381-397, 1982.
2. Baird L, Dinkova-Kostova A. The cytoprotective role of the Keap1/Nrf2 pathway. Arch Toxicol 85: 241-272, 2011.
3. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohé R. The GI-GPx gene is a target for Nrf2. Mol Cell Biol 25: 4914-4923, 2005.
4. Bellezza I, Mierla AL, Minelli A. Nrf2 and NF-κB and their concerted modulation in cancer pathogenesis and progression. Cancers 2: 483-497, 2010.
5. Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A, Bryce P, Cook-Mills JM. Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol 182: 4395-4405, 2009.
6. Bieri JG, McKenna MC. Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. Am J Clin Nutr 34: 289-295, 1981.
7. Brigelius-Flohé R, Traber MG. Vitamin E: function and metabolism. FASEB J 13: 1145-1155, 1999.
8. Brigelius-Flohé R. Bioactivity of vitamin E. Nutr Res Rev 19: 174-186, 2006.
9. Campbell SE, Musich PR, Whaley SG, Stimmel JB, Leesnitzer LM, Dessus-Babus S, Duffourc M, Stone W, Newman RA, Yang P, Krishnan K. γ-Tocopherol upregulates the expression of 15-S-HETE and induces growth arrest through a PPAR-dependent mechanism in PC-3 human prostate cancer cells. Nutr Cancer 61: 649-662, 2009.
10. Chen XM, Kitts DD. Determining conditions for nitric oxide synthesis in Caco-2 cells using Taguchi and factorial experimental designs. Anal Biochem 381: 185-192, 2008.
11. Committee on the Evaluation of the Addition of Ingredients New to Infant Formula. Infant Formula: Evaluating the Safety of New Ingredients. Washington, DC: National Academies Press, 2004, p. 7, 41-44.
12. Cook-Mills M, McCary A. Isoforms of vitamin E differentially regulate inflammation. Endocr Metab Immune Disord Drug Targets 10: 348-366, 2010.
13. Cooney RV, Franke AA, Harwood PJ, Hatch-Pigott V, Custer LJ, Mordan LJ. γ-Tocopherol detoxification of nitrogen dioxide: superiority to α-tocopherol. Proc Natl Acad Sci USA 90: 1771-1775, 1993.
14. Cui JG, Li YY, Zhao Y, Bhattacharjee S, Lukiw WJ. Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-κB in stressed human astroglial cells and in Alzheimer disease. J Biol Chem 285: 38951-38960, 2010.
15. Darzynkiewicz Z, Galkowski D, Zhao H. Analysis of apoptosis by cytometry using TUNEL assay. Methods 44: 250-254, 2008.
16. Devaraj S, Leonard S, Traber MG, Jialal I. γ -Tocopherol supplementation alone and in combination with α-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med 44: 1203-1208, 2008.
17. Elisia I, Popovich DG, Hu C, Kitts DD. Evaluation of viability assays for anthocyanins in cultured cells. Phytochem Anal 19: 479-486, 2008.
18. Elisia I, Kitts DD. Quantitation of hexanal as an index of lipid oxidation in human milk and association with antioxidant components. J Clin Biochem Nutr 49: 147-152, 2011.
19. Elisia I, Kitts DD. Different tocopherol isoforms vary in capacity to scavenge free radicals, prevent inflammatory response and induce apoptosis in both adult- and fetal-derived intestinal epithelial cells. Biofactors. In press.
20. Elisia I, Tsopmo A, Friel JK, Diehl-Jones W, Kitts DD. Tryptophan from human milk induces oxidative stress and upregulates the Nrf-2- mediated stress response in human intestinal cell lines. J Nutr 141: 1417-1423, 2011.
21. Evans HM, Bishop KS. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 56: 650-651, 1922.
22. Foldager C, Munir S, Ulrik-Vinther M, Søballe K, Bünger C, Lind M. Validation of suitable housekeeping genes for hypoxia-cultured human chondrocytes. BMC Mol Biol 10: 1-8, 2009.
23. Forman HJ, Dickinson DA. Oxidative signaling and glutathione synthesis. Biofactors 17: 1-12, 2003.
24. Franco R, Cidlowski JA. Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ 16: 1303-1314, 2009.
25. Garrington TP, Johnson GL. Organization and regulation of mitogenactivated protein kinase signaling pathways. Curr Opin Cell Biol 11: 211-218, 1999.
26. Griffith OW. Biologic and pharmacologic regulation of mammalian glutathione synthesis. Free Radic Biol Med 27: 922-935, 1999.
27. Hayes JD, McLellan LI. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 31: 273-300, 1999.
28. Hensley K, Benaksas EJ, Bolli R, Comp P, Grammas P, Hamdheydari L, Mou S, Pye QN, Stoddard MF, Wallis G, Williamson KS, West M, Wechter WJ, Floyd RA. New perspectives on vitamin E: γ-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med 36: 1-15, 2004.
29. Higgins LG, Hayes JD. Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and proinflammatory agents. Drug Metab Rev 43: 92-137, 2011.
30. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol 72: 847-855, 2002.
31. Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H, Inoue K. Affinity for γ-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett 409: 105-108, 1997.
32. Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN. γ-Tocopherol and its major metabolite, in contrast to α-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci USA 97: 11494-11499, 2000.
33. Kluck RM, Esposti MD, Perkins G, Renken C, Kuwana T, Bossy-Wetzel E, Goldberg M, Allen T, Barber MJ, Green DR, Newmeyer DD. The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol. J Cell Biol 147: 809-822, 1999.
34. Kunsch C, Rosen CA. NF-κB subunit-specific regulation of the interleukin- 8 promoter. Mol Cell Biol 13: 6137-6146, 1993.
35. Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, Kong AN. Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis. Biochem Pharmacol 76: 1485-1489, 2008.
36. Liu GH, Qu J, Shen X. NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta 1783: 713-727, 2008.
37. Lucas A, Cole TJ. Breast milk and neonatal necrotising enterocolitis. Lancet 336: 1519-1523, 1990.
38. McCormick CC, Parker RS. The cytotoxicity of vitamin E is both vitamer- and cell-specific and involves a selectable trait. J Nutr 134: 3335-3342, 2004.
39. Motohashi H, Yamamoto M. Nrf2/Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10: 549-557, 2004.
40. Nakashima S. Protein kinase Cα (PKCα): regulation and biological function. J Biochem 132: 669-675, 2002.
41. Nishikori M. Classical and alternative NF-κB activation pathways and their roles in lymphoid malignancies. J Clin Exp Hematop 45: 15-24, 2005.
42. Reboul E, Thap S, Perrot E, Amiot MJ, Lairon D, Borel P. Effect of the main dietary antioxidants (carotenoids, γ-tocopherol, polyphenols, and vitamin C) on tocopherol absorption. Eur J Clin Nutr 61: 1167-1173, 2007.
43. Ryan KM, Ernst MK, Rice NR, Vousden KH. Role of NF-κB in p53-mediated programmed cell death. Nature 404: 892-897, 2000.
44. SABiosciences: A Qiagen Company. RT2 Profiler™ PCR Array (Online). http://www.sabiosciences.com/PCRArrayPlate.php [27 June 2013].
45. Savinova OV, Hoffmann A, Ghosh G. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell 34: 591-602, 2009.
46. Schreck R, Albermann K, Baeuerle PA. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Radic Res 17: 221-237, 1992.
47. Senanayake SP, Fichtali J. Single-cell oils as sources of nutraceutical and specialty lipids: processing technologies and applications. In: Nutraceutical and Specialty Lipids and Their Co-Products, edited by Shahidi F. Boca Raton, FL: CRC, 2006.
48. Slater AF, Stefan C, Nobel I, Van Den Dobbelsteen DJ, Orrenius S. Signalling mechanisms and oxidative stress in apoptosis. Toxicol Lett 82/83: 149-153, 1995.
49. Sontag TJ, Parker RS. Cytochrome P450 ω-hydroxylase pathway of tocopherol catabolism. J Biol Chem 277: 25290-25296, 2002.
50. Sullivan S, Schanler RJ, Kim JH, Patel AL, Trawöger R, Kiechl- Kohlendorfer U, Chan GM, Blanco CL, Abrams S, Cotten CM, Laroia N, Ehrenkranz RA, Dudell G, Cristofalo EA, Meier P, Lee ML, Rechtman DJ, Lucas A. An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products. J Pediatr 156: 562-567, 2010.
51. Ten RM, Paya CM, Israel N, Bail OL, Mattei MG, Virelizier JL, Kourilsky P, Israel A. The characterization of the promoter of the gene encoding the p50 subunit of NF-κB indicates that it participates in its own regulation. EMBO J 11: 195-203, 1992.
52. Tsatsanis C, Androulidaki A, Venihaki M, Margioris AN. Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol 38: 1654-1661, 2006.
53. Wagner KH, Kamal-Eldin A, Elmadfa I. γ-Tocopherol-an underestimated vitamin? Ann Nutr Metab 48: 169-188, 2004.
54. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr 134: 489-492, 2004.
55. Yu M, Li H, Liu Q, Liu F, Tang L, Li C, Yuan Y, Zhan Y, Xu W, Li W, Chen H, Ge C, Wang J, Yang X. Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal 23: 883-892, 2011.
56. Zhang H, Forman HJ. Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol 23: 722-728, 2012.
57. Zhang X, Chen X, Song H, Chen HZ, Rovin B. Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur J Immunol 35: 3258-3267, 2005.