Tryptophan from human milk induces oxidative stress and upregulates the Nrf-2-mediated stress response in human intestinal cell lines

Journal of Nutrition

Volumn 141, Issue 8, 2011, Pages 1417-1423

  Elisia, Ingrid ^a   Tsopmo, Apollinaire ^b   Friel, James K ^c   Diehl Jones, William ^c   Kitts, David D ^a  

^a Food Nutrition and Health   (Canada)

^b CARLETON UNIVERSITY   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2, 2' AZOBIS (2 AMIDINOPROPANE) DIHYDROCHLORIDE; ACETOACETIC ACID; DICHLOROFLUORESCEIN; GLUTATHIONE PEROXIDASE 2; OXYGEN RADICAL; PEPTIDE; PEPTIDE FRACTION 23; PEROXY RADICAL; TRANSCRIPTION FACTOR NRF2; TRYPTOPHAN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANTIOXIDANT ACTIVITY; ARTICLE; CARCINOMA CELL; CELL CULTURE; CELL LINE; CELL STRAIN CACO 2; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE ASSOCIATION; FEMALE; FETUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; INTESTINE CELL; MILK; MODULATION; OXIDATION; OXIDATIVE STRESS; STRESS; UPREGULATION;

CACO-2 CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INTESTINES; MILK, HUMAN; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; TRYPTOPHAN; UP-REGULATION;

EID: 79961114358     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.111.139451     Document Type: Article

References (21)

1. Hamosh M. Bioactive factors in human milk. Pediatr Clin North Am. 2001;48:69-86.
2. Buescher ES, McIlheran SM. Antioxidant properties of human colostrum. Pediatr Res. 1988;24:14-9.
3. Friel JK, Martin SM, Langdon M, Herzberg GR, Buettner GR. Milk from mothers of both premature and full-term infants provides better antioxidant protection than does infant formula. Pediatr Res. 2002;51:612-8.
4. Saugstad OD. Oxygen toxicity in the neonatal period. Acta Paediatr Scand. 1990;79:88192.
5. Jensen RG. Handbook of milk composition. San Diego: Academic Press; 1995.
6. Kitts DD, Weiler K. Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr Pharm Des. 2003;9:130923.
7. Tsopmo A, Diehl-Jones WL, Aluko RE, Kitts DD, Elisia I, Friel JK. Tryptophan released from mother's milk has antioxidant properties. Pediatr Res. 2009;66:614-8.
8. Tijerina-Sáenz A, Elisia I, Innis SM, Friel JK, Kitts DD. Use of ORAC to assess oxidative stability in human milk. J Food Compost Anal. 2009; 22:694-8.
9. Hidalgo IJ. Cultured intestinal epithelial cell models. In: Borchardt RT, Smith PL, Wilson G, editors. Models for assessing drug absorption and metabolism. New York: Plenum Publishing Corporation; 1996. p. 35-50.
10. 2 Profiler PCR array data analysis [cited 2011 Mar 19]. Available from: http://pcrdataanalysis.sabiosciences.com/pcr/arrayanalysis.php.
11. Urakami M, Ano R, Kimura Y, Shima M, Matsuno R, Ueno T, Akamatsu M. Relationship between structure and permeability of tryptophan derivatives across human intestinal epithelial (caco-2) cells. Z Naturforsch C. 2003;58:135-42.
12. Wahl RUR, Zeng L, Madison SA, DePinto RL, Shay BJ. Mechanistic studies on the decomposition of water soluble azo-radical-initiators. J Chem Soc Perkin. 1998;2:2009-17.
13. Howell S, Kenny AJ, Turner AJ. A survey of membrane peptidases in two human colonic cell lines, caco-2 and ht-29. Biochem J. 1992;284: 595-601.
14. Satake M, Enjoh M, Nakamura Y, Takano T, Kawamura Y, Arai S, Shimizu M. Transepithelial transport of the bioactive tripeptide, val pro-pro, in human intestinal caco-2 cell monolayers. Biosci Biotechnol Biochem. 2002;66:378-84.
15. Steinhart H, Meyer K, Vollmar M. Stability of tryptophan-containing peptides in the presence of an l-ascorbic acid-ferric ion system. J Agric Food Chem. 1995;43:2321-4.
16. Moosmann B, Behl C. Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins. Eur J Biochem. 2000;267:5687-92.
17. Cadenas E, Davies KJA. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000;29: 222-30.
18. Nauser T, Koppenol WH, Gebicki JM. The kinetics of oxidation of GSH by protein radicals. Biochem J. 2005;392:693-701.
19. Ostdal H, Davies MJ, Andersen HJ. Reaction between protein radicals and other biomolecules. Free Radic Biol Med. 2002;33: 201-9.
20. Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem. 2009;284:13291-5.
21. Brigelius-Flohé R. Glutathione peroxidases and redox-regulated transcription factors. Biol Chem. 2006;387:1329-35.