Abrogation of ER stress-induced apoptosis of alveolar epithelial cells by angiotensin 1-7

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 305, Issue 1, 2013, Pages

  Uhal, Bruce D ^a   Nguyen, Hang ^b   Dang, MyTrang ^c   Gopallawa, Indiwari ^b   Jiang, Jing ^a   Dang, Vinh ^a   Ono, Shinji ^d   Morimoto, Konosuke ^e  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c Nagasaki University ^*  (United States)

^d NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^e NAGASAKI UNIVERSITY   (Japan)

Author keywords

ADAM17 TACE; BRICHOS domain mutations; Idiopathic pulmonary fibrosis; Substituted peptide receptor antagonists

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; ANGIOTENSINOGEN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BLEOMYCIN; CASPASE 7; CASPASE 8; CATHEPSIN D; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PROPIDIUM IODIDE; SARALASIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOTHESIS; INDUCED MUTATION; INTRACELLULAR SIGNALING; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION; WESTERN BLOTTING;

ADAM17/TACE; BRICHOS DOMAIN MUTATIONS; IDIOPATHIC PULMONARY FIBROSIS; SUBSTITUTED PEPTIDE RECEPTOR ANTAGONISTS;

ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANTIHYPERTENSIVE AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOCRINE COMMUNICATION; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL CELLS; HUMANS; LEUPEPTINS; PEPTIDE FRAGMENTS; PULMONARY ALVEOLI; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; RECEPTORS, ANGIOTENSIN; SIGNAL TRANSDUCTION; VASOCONSTRICTOR AGENTS;

EID: 84879594593     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00001.2013     Document Type: Article

References (29)

1. Adamson IYR, Bowden DH. Pulmonary injury and repair. Organ culture studies of murine lung after oxygen. Arch Pathol Lab Med 100: 640-643, 1976.
2. Budinger GR, Mutlu GM, Eisenbart J, Fuller AC, Bellmeyer AA, Baker CM, Wilson M, Ridge K, Barrett TA, Lee VY, Chandel NS. Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci USA 103: 4604-4609, 2006.
3. Couluris M, Kinder BW, Xu P, Gross-King M, Krischer J, Panos RJ. Treatment of idiopathic pulmonary fibrosis with losartan: a pilot project. Lung 190: 523-527, 2012.
4. Haga S, Nagata N, Okamura T, Yamamoto N, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res 85: 551-555, 2010.
5. Hagimoto N, Kuwano K, Miyazaki H, Kunitake R, Fujita M, Kawasaki M, Kanika Y, Hara H. Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of FAS antigen. Am J Respir Cell Mol Biol 17: 272-278, 1997.
6. Haschek WM, Witschi HP. Pulmonary fibrosis: a possible mechanism. Toxicol Appl Pharmacol 51: 475-487, 1979.
7. Korfei M, Ruppert C, Mahavadi P, Henneke I, Markart P, Koch M, Lang G, Fink L, Bohle RM, Seeger W, Weaver TE, Guenther A. Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 178: 838-846, 2008.
8. Kuwano K, Kunitake R, Maeyama T, Hagimoto N, Kawasaki M, Matsuba T, Yoshimi M, Inoshima I, Yoshida K, Hara N. Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 280: L316-L325, 2001.
9. Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol 294: L1119-L1126, 2008.
10. Li X, Molina-Molina M, Abdul-Hafez A, Ramirez J, Serrano-Mollar A, Xaubet A, Uhal BD. Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 291: L887-L895, 2006.
11. Li X, Molina-Molina M, Abdul-Hafez A, Xaubet A, Uhal BD. Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis. Am J Physiol Lung Cell Mol Physiol 295: L178-L185, 2008.
12. Li X, Rayford H, Shu R, Zhuang J, Uhal BD. Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 287: L46-L51, 2004.
13. Li X, Zhang H, Soledad-Conrad V, Zhuang J, Uhal BD. Bleomycininduced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novo. Am J Physiol Lung Cell Mol Physiol 284: L501-L507, 2003.
14. Maguire JA, Mulugeta S, Beers MF. Multiple ways to die: delineation of the unfolded protein response and apoptosis induced by surfactant protein C BRICHOS mutants. Int J Biochem Cell Biol 44: 101-112, 2012.
15. Mulugeta S, Maguire JA, Newitt JL, Russo SJ, Kotorashvili A, Beers MF. Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4-and cytochrome c-related mechanisms. Am J Physiol Lung Cell Mol Physiol 293: L720-L729, 2007.
16. Mulugeta S, Nguyen V, Russo SJ, Muniswamy M, Beers MF. A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation. Am J Respir Cell Mol Biol 32: 521-530, 2005.
17. Ono S, Tanaka T, Ishida M, Kinoshita A, Fukuoka J, Takaki M, Sakamoto N, Ishimatsu Y, Kohno S, Hayashi T, Senba M, Yasunami M, Kubo Y, Yoshida LM, Kubo H, Ariyoshi K, Yoshiura K, Morimoto K. Surfactant protein C G100S mutation causes familial pulmonary fibrosis in Japanese kindred. Eur Respir J 38: 861-869, 2001.
18. Rzymski T, Petry A, Kračun D, Rieb F, Pike L, Harris AL, Görlach A. The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. Oncogene 31: 3621-3634, 2012.
19. Shenoy V, Ferreira AJ, Qi Y, Fraga-Silva RA, Díez-Freire C, Dooies A, Jun JY, Sriramula S, Mariappan N, Pourang D, Venugopal CS, Francis J, Reudelhuber T, Santos RA, Patel JM, Raizada MK, Katovich MJ. The ACE2/Ang-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension. Am J Respir Crit Care Med 182: 1065-1072, 2010.
20. Uhal BD. The role of apoptosis in pulmonary fibrosis. Eur Respir Rev 17: 109, 138-143, 2008.
21. Uhal BD, Dang M, Dang V, Llatos R, Cano E, Abdul-Hafez A, Markey J, Piasecki CC, Molina-Molina M. Cell cycle-dependence of ACE-2 explains downregulation in Idiopathic pulmonary fibrosis. Eur Respir J 2012 Dec 20. [Epub ahead of print].
22. Uhal BD, Flowers KM, Rannels DE. Type II pneumocyte proliferation in vitro: problems and future directions. Am J Physiol Lung Cell Mol Physiol 261: L110-L117, 1991.
23. Uhal BD, Li X, Xue A, Gao X, Abdul-Hafez A. Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1-7/Mas axis. Am J Physiol Lung Cell Mol Physiol 301: L269-L274, 2011.
24. Wang R, Alam G, Zagariya A, Gidea C, Pinillos H, Lalude O, Choudhary G, Uhal BD. Apoptosis of lung epithelial cells in response to TNF-alpha requires angiotensin II generation de novo. J Cell Physiol 185: 253-259, 2000.
25. Wang R, Ibarra-Sunga O, Pick R, Uhal BD. Abrogation of bleomycininduced epithelial apoptosis and lung fibrosis by captopril or by a caspase inhibitor. Am J Physiol Lung Cell Mol Physiol 279: L143-L151, 2000.
26. Wang R, Zagariya A, Ang E, Ibarra-Sunga O, Uhal BD. Fas-induced apoptosis of alveolar epithelial cells requires angiotensin II generation and receptor interaction. Am J Physiol Lung Cell Mol Physiol 277: L1245-L1250, 1999.
27. Weichert N, Kaltenborn E, Hector A, Woischnik M, Schams A, Holzinger A, Kern S, Griese M. Some ABCA3 mutations elevate ER stress and initiate apoptosis of lung epithelial cells. Respir Res 12: 4-16, 2011.
28. Whitsett JA. Genetic basis of familial interstitial lung disease. Misfolding or function of surfactant protein c? Am J Respir Crit Care Med 165: 1201-1204, 2002.
29. Woo DS, Seol WJ, Kyung SY, Lim YH, An CH, Park JW, Jeong SH, Lee JW. The therapeutic effect of angiotensin II receptor antagonist in idiopathic pulmonary fibrosis. Tuberc Respir Dis 55: 478-487, 2003.