Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) Silencing

Journal of Biological Chemistry

Volumn 288, Issue 49, 2013, Pages 35534-35547

  Chung, Jihyun ^a   Karkhanis, Vrajesh ^a   Tae, Sookil ^a   Yan, Fengting ^a   Smith, Porsha ^a   Ayers, Leona W ^a   Agostinelli, Claudio ^b   Pileri, Stefano ^b   Denis, Gerald V ^c   Baiocchi, Robert A ^a   Sif, Saïd ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIND1; GROWTH ARREST; LYMPHOMA CELLS; NON-HODGKIN LYMPHOMA; POLYCOMB; PROTEIN-ARGININE METHYLTRANSFERASE; RETINOBLASTOMA TUMORS;

AMINO ACIDS;

CELL DEATH;

CASPASE 10; CELL PROTEIN; CYCLIN D1; DEATH ASSOCIATED PROTEIN 1; GLYCEROL 2 PHOSPHATE; GREEN FLUORESCENT PROTEIN; HARAKIRI PROTEIN; LENTIVIRUS VECTOR; METHYLTRANSFERASE INHIBITOR; OLIGONUCLEOTIDE; PLACEBO; POLYCLONAL ANTIBODY; POLYCOMB REPRESSIVE COMPLEX 2; PROTEIN ARGININE METHYLTRANSFERASE; PROTEIN ARGININE METHYLTRANSFERASE 5; PROTEIN P130; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN 1; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR HOXA5; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CASP10 GENE; COMPLEX FORMATION; CONTROLLED STUDY; DAP1 GENE; DRUG TARGETING; ENZYME INHIBITION; EPIGENETICS; EXPERIMENTAL MOUSE; GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HOXA5 GENE; HRK GENE; HUMAN; HUMAN CELL; LYMPHOMA CELL; MOUSE; NONHODGKIN LYMPHOMA; NONHUMAN; PRC2 GENE; PRIMARY TUMOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; RB1 GENE; RBL2 GENE; TRANSCRIPTION REGULATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM;

CHROMATIN HISTONE MODIFICATION; CYCLIN D1; LEUKEMIA; LYMPHOMA; PRC2; PRMT5; RB1; RBL2; RETINOBLASTOMA (RB);

ANIMALS; CELL DEATH; CELL LINE, TUMOR; CYCLIN D1; EPIGENESIS, GENETIC; GENE KNOCKDOWN TECHNIQUES; GENES, RETINOBLASTOMA; HISTONE DEACETYLASE 2; HUMANS; LYMPHOMA; LYMPHOMA, NON-HODGKIN; MICE; POLYCOMB REPRESSIVE COMPLEX 2; PROMOTER REGIONS, GENETIC; PROTEIN METHYLTRANSFERASES; PROTEIN-ARGININE N-METHYLTRANSFERASES; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P130; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84890288945     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.510669     Document Type: Article

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