Chronic intake of onion extract containing quercetin improved postprandial endothelial dysfunction in healthy men

Journal of the American College of Nutrition

Volumn 32, Issue 3, 2013, Pages 160-164

  Higashi, Yukihito ^b   Tsuge, Nobuaki ^a   Sawada, Hiroshi ^a  

^a House Foods Corporation   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cardiovascular events; Endothelial function; Flow mediated vasodilation; Onion; Postprandial hyperglycemia; Prevention; Quercetin

Indexed keywords

ANTIOXIDANT; MALTOSE; PLANT EXTRACT; QUERCETIN;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR SYSTEM; CHEMISTRY; DIET RESTRICTION; DRUG EFFECT; FOREARM; HUMAN; MALE; METABOLISM; MIDDLE AGED; ONION; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; POSTPRANDIAL STATE; VASCULAR ENDOTHELIUM; VASODILATATION; CARDIOVASCULAR DISEASES; DRUG EFFECTS;

ADMINISTRATION, ORAL; ADULT; ANTIOXIDANTS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; ENDOTHELIUM, VASCULAR; FASTING; FOREARM; HUMANS; MALE; MALTOSE; MIDDLE AGED; ONIONS; PLANT EXTRACTS; POSTPRANDIAL PERIOD; QUERCETIN; VASODILATION;

EID: 84890265385     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2013.797858     Document Type: Article

References (21)

1. CoutinhoM, GersteinHC, WangY, YusufS: The relationship between glucose and incident cardiovascular events. Ametaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care22:233-240, 1999.
2. CerielloA: New insights on oxidative stress and diabetic complications may lead to a “causal” antioxidant therapy. Diabetes Care26:1589-1596, 2003.
3. KawanoH, MotoyamaT, Hirashima O, Hirai N, Miyao Y, Sakamoto T, Kugiyama K, Ogawa H, Yasue H: Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol34:146-154, 1999.
4. Lefebvre PJ, Scheen AJ: The postprandial state and risk of cardiovascular disease. Diabet Med 15(suppl 4):S63-S68, 1998.
5. O’KeefeJH, GheewalaNM, O’KeefeJO: Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol51:249-255, 2008.
6. NodeK, InoueT: Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol8:23, 2009.
7. HuxleyRR, Neil HAW: The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur J Clin Nutr57:904-908, 2003.
8. DuffySJ, KeaneyJrJF, HolbrookM, GokceN, SwerdloffPL, FreiB, VitaJA: Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation104:151-156, 2001.
9. SchroeterH, HeissC, BalzerJ, KleinbongardP, KeenCL, HollenbergNK, SiesH, Kwik-UribeC, SchmitzHH, Kelm M: Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci USA 103:1024-1029, 2006.
10. BalzerJ, RassafT, HeissC, KleinbongardP, LauerT, MerxM, HeussenN, GrossHB, KeenCL, SchroeterH, KelmM: Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial. J Am Coll Cardiol51:2141-2149, 2008.
11. LekakisJ, RallidisLS, AndreadouI, VamvakouG, KazantzoglouG, MagiatisP, SkaltsounisA-L, KremastinosDT: Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil12:596-600, 2005.
12. ChavesAA, Joshi MS, Coyle CM, Brady JE, Dech SJ, Schanbacher BL, Baliga R, Basuray A, Bauer JA: Vasoprotective endothelial effects of a standardized grape product in humans. Vascul Pharmacol50:20-26, 2009.
13. BryansJA, JuddPA, EllisPR: The effect of consuming instant black tea on postprandial plasma glucose and insulin concentrations in healthy humans. J Am Coll Nutr26:471-477, 2007.
14. ErdmanJW Jr, BalentineD, ArabL, BeecherG, DwyerJT, FoltsJ, HarnlyJ, HollmanP, KeenCL, MazzaG, MessinaM, ScalbertA, VitaJ, WilliamsonG, BurrowesJ: Flavonoids and heart health: proceedings of the ILSI North America FlavonoidsWorkshop, May 31-June 1, 2005, Washington, DC. J Nutr137:718S-737S, 2007.
15. SanchezM, LodiF, VeraR, VillarIC, CogolludoA, JimenezR, MorenoL, RomeroM, TamargoJ, Perez-VizcainoF, DuarteJ: Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. J Nutr137:910-915, 2007.
16. TsushidaT, SuzukiM: Isolation of flavonoid-glycosides in onion and identification by chemical synthesis of the glycosides (flavonoid in fruits and vegetables part 1). J Jpn Soc Food Sci Technol 42:100-108, 1995.
17. TitleLM, CummingsPM, GiddensK, NassarBA: Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C andE. J Am Coll Cardiol36:2185-2191, 2000.
18. Lee I-K, Kim H-S, Bae J-H: Endothelial dysfunction: its relationship with acute hyperglycaemia and hyperlipidemia. Int J Clin Pract Jul:59-64, 2002.
19. EgertS, WolfframS, Bosy-WestphalA, Boesch-SaadatmandiC, WagnerAE, FrankJ, RimbachG, MuellerMJ: Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr138:1615-1621, 2008.
20. LeeK-H, ParkE, LeeH-J, KimM-O, ChaY-J, KimJ-M, LeeH, ShinM-J: Effects of daily quercetin-rich supplementation on cardiometabolic risks in male smokers. Nutr Res Pract5:28-33, 2011.
21. PfeufferM, AuingerA, BleyU, Kraus-StojanowicI, LaueC, WinklerP, RüferCE, FrankJ, Bösch-SaadatmandiC, RimbachG, SchrezenmeirJ: Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. NutrMetab Cardiovasc Dis 23:403-409, 2013.