-
1
-
-
23944474593
-
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
-
Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Cell Death Differ. 2005, 12:1178-1190.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 1178-1190
-
-
Ciechanover, A.1
-
3
-
-
50149086108
-
Diversity of degradation signals in the ubiquitin-proteasome system
-
Ravid T., Hochstrasser M. Diversity of degradation signals in the ubiquitin-proteasome system. Nat. Rev. Mol. Cell Biol. 2008, 9:679-690.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 679-690
-
-
Ravid, T.1
Hochstrasser, M.2
-
4
-
-
59649086030
-
Nonproteolytic functions of ubiquitin in cell signaling
-
Chen Z.J., Sun L.J. Nonproteolytic functions of ubiquitin in cell signaling. Mol. Cell 2009, 33:275-286.
-
(2009)
Mol. Cell
, vol.33
, pp. 275-286
-
-
Chen, Z.J.1
Sun, L.J.2
-
5
-
-
44649101850
-
Atypical ubiquitin chains: new molecular signals. 'Protein modifications: beyond the usual suspects' review series
-
Ikeda F., Dikic I. Atypical ubiquitin chains: new molecular signals. 'Protein modifications: beyond the usual suspects' review series. EMBO Rep. 2008, 9:536-542.
-
(2008)
EMBO Rep.
, vol.9
, pp. 536-542
-
-
Ikeda, F.1
Dikic, I.2
-
6
-
-
79955620198
-
Constructing and decoding unconventional ubiquitin chains
-
Behrends C., Harper J.W. Constructing and decoding unconventional ubiquitin chains. Nat. Struct. Mol. Biol. 2011, 18:520-528.
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 520-528
-
-
Behrends, C.1
Harper, J.W.2
-
7
-
-
33750219981
-
A ubiquitin ligase complex assembles linear polyubiquitin chains
-
Kirisako T., Kamei K., Murata S., Kato M., Fukumoto H., Kanie M., Sano S., Tokunaga F., Tanaka K., Iwai K. A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 2006, 25:4877-4887.
-
(2006)
EMBO J.
, vol.25
, pp. 4877-4887
-
-
Kirisako, T.1
Kamei, K.2
Murata, S.3
Kato, M.4
Fukumoto, H.5
Kanie, M.6
Sano, S.7
Tokunaga, F.8
Tanaka, K.9
Iwai, K.10
-
8
-
-
67650064603
-
Linear polyubiquitination: a new regulator of NF-κB activation
-
Iwai K., Tokunaga F. Linear polyubiquitination: a new regulator of NF-κB activation. EMBO Rep. 2009, 10:706-713.
-
(2009)
EMBO Rep.
, vol.10
, pp. 706-713
-
-
Iwai, K.1
Tokunaga, F.2
-
9
-
-
80052906832
-
Linear polyubiquitin chains: a new modifier involved in NF-κB activation and chronic inflammation, including dermatitis
-
Iwai K. Linear polyubiquitin chains: a new modifier involved in NF-κB activation and chronic inflammation, including dermatitis. Cell Cycle 2011, 10:3095-3104.
-
(2011)
Cell Cycle
, vol.10
, pp. 3095-3104
-
-
Iwai, K.1
-
11
-
-
38849199203
-
Shared principles in NF-κB signaling
-
Hayden M.S., Ghosh S. Shared principles in NF-κB signaling. Cell 2008, 132:344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
13
-
-
80052014052
-
Inflammation meets cancer, with NF-κB as the matchmaker
-
Ben-Neriah Y., Karin M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat. Immunol. 2011, 12:715-723.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 715-723
-
-
Ben-Neriah, Y.1
Karin, M.2
-
14
-
-
2342464085
-
The two NF-κB activation pathways and their role in innate and adaptive immunity
-
Bonizzi G., Karin M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004, 25:280-288.
-
(2004)
Trends Immunol.
, vol.25
, pp. 280-288
-
-
Bonizzi, G.1
Karin, M.2
-
15
-
-
65249083913
-
Ubiquitin in NF-κB signaling
-
Chiu Y.H., Zhao M., Chen Z.J. Ubiquitin in NF-κB signaling. Chem. Rev. 2009, 109:1549-1560.
-
(2009)
Chem. Rev.
, vol.109
, pp. 1549-1560
-
-
Chiu, Y.H.1
Zhao, M.2
Chen, Z.J.3
-
16
-
-
77957252647
-
The IKK complex, a central regulator of NF-κB activation
-
Israel A. The IKK complex, a central regulator of NF-κB activation. Cold Spring Harb. Perspect. Biol. 2010, 2:a000158.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
-
-
Israel, A.1
-
17
-
-
78650920066
-
Non-canonical NF-κB signaling pathway
-
Sun S.C. Non-canonical NF-κB signaling pathway. Cell Res. 2011, 21:71-85.
-
(2011)
Cell Res.
, vol.21
, pp. 71-85
-
-
Sun, S.C.1
-
18
-
-
84859430011
-
Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma
-
Busino L., Millman S.E., Scotto L., Kyratsous C.A., Basrur V., O'Connor O., Hoffmann A., Elenitoba-Johnson K.S., Pagano M. Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat. Cell Biol. 2012, 14:375-385.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 375-385
-
-
Busino, L.1
Millman, S.E.2
Scotto, L.3
Kyratsous, C.A.4
Basrur, V.5
O'Connor, O.6
Hoffmann, A.7
Elenitoba-Johnson, K.S.8
Pagano, M.9
-
19
-
-
67650744586
-
The role of ubiquitin in NF-κB regulatory pathways
-
Skaug B., Jiang X., Chen Z.J. The role of ubiquitin in NF-κB regulatory pathways. Annu. Rev. Biochem. 2009, 78:769-796.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 769-796
-
-
Skaug, B.1
Jiang, X.2
Chen, Z.J.3
-
20
-
-
0024514688
-
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
-
Chau V., Tobias J.W., Bachmair A., Marriott D., Ecker D.J., Gonda D.K., Varshavsky A. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 1989, 243:1576-1583.
-
(1989)
Science
, vol.243
, pp. 1576-1583
-
-
Chau, V.1
Tobias, J.W.2
Bachmair, A.3
Marriott, D.4
Ecker, D.J.5
Gonda, D.K.6
Varshavsky, A.7
-
21
-
-
0028847989
-
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
-
Spence J., Sadis S., Haas A.L., Finley D. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol. Cell. Biol. 1995, 15:1265-1273.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1265-1273
-
-
Spence, J.1
Sadis, S.2
Haas, A.L.3
Finley, D.4
-
22
-
-
0034644474
-
Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., Chen Z.J. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000, 103:351-361.
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
23
-
-
43249120917
-
Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and Toll-like receptor-mediated NF-kappaB activation
-
Conze D.B., Wu C.J., Thomas J.A., Landstrom A., Ashwell J.D. Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and Toll-like receptor-mediated NF-kappaB activation. Mol. Cell. Biol. 2008, 28:3538-3547.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3538-3547
-
-
Conze, D.B.1
Wu, C.J.2
Thomas, J.A.3
Landstrom, A.4
Ashwell, J.D.5
-
25
-
-
34248570795
-
Ubiquitin-mediated activation of TAK1 and IKK
-
Adhikari A., Xu M., Chen Z.J. Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 2007, 26:3214-3226.
-
(2007)
Oncogene
, vol.26
, pp. 3214-3226
-
-
Adhikari, A.1
Xu, M.2
Chen, Z.J.3
-
26
-
-
69949093459
-
Direct activation of protein kinases by unanchored polyubiquitin chains
-
Xia Z.P., Sun L., Chen X., Pineda G., Jiang X., Adhikari A., Zeng W., Chen Z.J. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 2009, 461:114-119.
-
(2009)
Nature
, vol.461
, pp. 114-119
-
-
Xia, Z.P.1
Sun, L.2
Chen, X.3
Pineda, G.4
Jiang, X.5
Adhikari, A.6
Zeng, W.7
Chen, Z.J.8
-
27
-
-
33747615237
-
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
-
Yamamoto M., Okamoto T., Takeda K., Sato S., Sanjo H., Uematsu S., Saitoh T., Yamamoto N., Sakurai H., Ishii K.J., Yamaoka S., Kawai T., Matsuura Y., Takeuchi O., Akira S. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 2006, 7:962-970.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 962-970
-
-
Yamamoto, M.1
Okamoto, T.2
Takeda, K.3
Sato, S.4
Sanjo, H.5
Uematsu, S.6
Saitoh, T.7
Yamamoto, N.8
Sakurai, H.9
Ishii, K.J.10
Yamaoka, S.11
Kawai, T.12
Matsuura, Y.13
Takeuchi, O.14
Akira, S.15
-
28
-
-
70350015537
-
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFα and IL-1β
-
Xu M., Skaug B., Zeng W., Chen Z.J. A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFα and IL-1β. Mol. Cell 2009, 36:302-314.
-
(2009)
Mol. Cell
, vol.36
, pp. 302-314
-
-
Xu, M.1
Skaug, B.2
Zeng, W.3
Chen, Z.J.4
-
30
-
-
30344482590
-
Lingering mysteries of ubiquitin-chain assembly
-
Hochstrasser M. Lingering mysteries of ubiquitin-chain assembly. Cell 2006, 124:27-34.
-
(2006)
Cell
, vol.124
, pp. 27-34
-
-
Hochstrasser, M.1
-
31
-
-
70350461507
-
Building ubiquitin chains: E2 enzymes at work
-
Ye Y., Rape M. Building ubiquitin chains: E2 enzymes at work. Nat. Rev. Mol. Cell Biol. 2009, 10:755-764.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 755-764
-
-
Ye, Y.1
Rape, M.2
-
32
-
-
0033525582
-
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair
-
Hofmann R.M., Pickart C.M. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 1999, 96:645-653.
-
(1999)
Cell
, vol.96
, pp. 645-653
-
-
Hofmann, R.M.1
Pickart, C.M.2
-
33
-
-
59649103156
-
Involvement of linear polyubiquitylation of NEMO in NF-κB activation
-
Tokunaga F., Sakata S., Saeki Y., Satomi Y., Kirisako T., Kamei K., Nakagawa T., Kato M., Murata S., Yamaoka S., Yamamoto M., Akira S., Takao T., Tanaka K., Iwai K. Involvement of linear polyubiquitylation of NEMO in NF-κB activation. Nat. Cell Biol. 2009, 11:123-132.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
Sakata, S.2
Saeki, Y.3
Satomi, Y.4
Kirisako, T.5
Kamei, K.6
Nakagawa, T.7
Kato, M.8
Murata, S.9
Yamaoka, S.10
Yamamoto, M.11
Akira, S.12
Takao, T.13
Tanaka, K.14
Iwai, K.15
-
34
-
-
0033638970
-
NEMO/IKK gamma-deficient mice model incontinentia pigmenti
-
Schmidt-Supprian M., Bloch W., Courtois G., Addicks K., Israel A., Rajewsky K., Pasparakis M. NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol. Cell 2000, 5:981-992.
-
(2000)
Mol. Cell
, vol.5
, pp. 981-992
-
-
Schmidt-Supprian, M.1
Bloch, W.2
Courtois, G.3
Addicks, K.4
Israel, A.5
Rajewsky, K.6
Pasparakis, M.7
-
35
-
-
0034175632
-
Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice
-
Rudolph D., Yeh W.C., Wakeham A., Rudolph B., Nallainathan D., Potter J., Elia A.J., Mak T.W. Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice. Genes Dev. 2000, 14:854-862.
-
(2000)
Genes Dev.
, vol.14
, pp. 854-862
-
-
Rudolph, D.1
Yeh, W.C.2
Wakeham, A.3
Rudolph, B.4
Nallainathan, D.5
Potter, J.6
Elia, A.J.7
Mak, T.W.8
-
36
-
-
0033532386
-
The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
-
Li Z.W., Chu W., Hu Y., Delhase M., Deerinck T., Ellisman M., Johnson R., Karin M. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J. Exp. Med. 1999, 189:1839-1845.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1839-1845
-
-
Li, Z.W.1
Chu, W.2
Hu, Y.3
Delhase, M.4
Deerinck, T.5
Ellisman, M.6
Johnson, R.7
Karin, M.8
-
37
-
-
79953237668
-
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
-
Tokunaga F., Nakagawa T., Nakahara M., Saeki Y., Taniguchi M., Sakata S., Tanaka K., Nakano H., Iwai K. SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex. Nature 2011, 471:633-636.
-
(2011)
Nature
, vol.471
, pp. 633-636
-
-
Tokunaga, F.1
Nakagawa, T.2
Nakahara, M.3
Saeki, Y.4
Taniguchi, M.5
Sakata, S.6
Tanaka, K.7
Nakano, H.8
Iwai, K.9
-
38
-
-
79953239980
-
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
-
Ikeda F., Deribe Y.L., Skanland S.S., Stieglitz B., Grabbe C., Franz-Wachtel M., van Wijk S.J., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J.P., Schaefer L., Rittinger K., Macek B., Dikic I. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 2011, 471:637-641.
-
(2011)
Nature
, vol.471
, pp. 637-641
-
-
Ikeda, F.1
Deribe, Y.L.2
Skanland, S.S.3
Stieglitz, B.4
Grabbe, C.5
Franz-Wachtel, M.6
van Wijk, S.J.7
Goswami, P.8
Nagy, V.9
Terzic, J.10
Tokunaga, F.11
Androulidaki, A.12
Nakagawa, T.13
Pasparakis, M.14
Iwai, K.15
Sundberg, J.P.16
Schaefer, L.17
Rittinger, K.18
Macek, B.19
Dikic, I.20
more..
-
39
-
-
79953240109
-
Linear ubiquitination prevents inflammation and regulates immune signalling
-
Gerlach B., Cordier S.M., Schmukle A.C., Emmerich C.H., Rieser E., Haas T.L., Webb A.I., Rickard J.A., Anderton H., Wong W.W., Nachbur U., Gangoda L., Warnken U., Purcell A.W., Silke J., Walczak H. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 2011, 471:591-596.
-
(2011)
Nature
, vol.471
, pp. 591-596
-
-
Gerlach, B.1
Cordier, S.M.2
Schmukle, A.C.3
Emmerich, C.H.4
Rieser, E.5
Haas, T.L.6
Webb, A.I.7
Rickard, J.A.8
Anderton, H.9
Wong, W.W.10
Nachbur, U.11
Gangoda, L.12
Warnken, U.13
Purcell, A.W.14
Silke, J.15
Walczak, H.16
-
40
-
-
34547422758
-
Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis
-
Seymour R.E., Hasham M.G., Cox G.A., Shultz L.D., Hogenesch H., Roopenian D.C., Sundberg J.P. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immunol. 2007, 8:416-421.
-
(2007)
Genes Immunol.
, vol.8
, pp. 416-421
-
-
Seymour, R.E.1
Hasham, M.G.2
Cox, G.A.3
Shultz, L.D.4
Hogenesch, H.5
Roopenian, D.C.6
Sundberg, J.P.7
-
41
-
-
0027773019
-
A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice
-
HogenEsch H., Gijbels M.J., Offerman E., van Hooft J., van Bekkum D.W., Zurcher C. A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am. J. Pathol. 1993, 143:972-982.
-
(1993)
Am. J. Pathol.
, vol.143
, pp. 972-982
-
-
HogenEsch, H.1
Gijbels, M.J.2
Offerman, E.3
van Hooft, J.4
van Bekkum, D.W.5
Zurcher, C.6
-
42
-
-
84869429707
-
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
-
Boisson B., Laplantine E., Prando C., Giliani S., Israelsson E., Xu Z., Abhyankar A., Israel L., Trevejo-Nunez G., Bogunovic D., Cepika A.M., Macduff D., Chrabieh M., Hubeau M., Bajolle F., Debre M., Mazzolari E., Vairo D., Agou F., Virgin H.W., Bossuyt X., Rambaud C., Facchetti F., Bonnet D., Quartier P., Fournet J.C., Pascual V., Chaussabel D., Notarangelo L.D., Puel A., Israel A., Casanova J.L., Picard C. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat. Immunol. 2012, 13:1178-1186.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 1178-1186
-
-
Boisson, B.1
Laplantine, E.2
Prando, C.3
Giliani, S.4
Israelsson, E.5
Xu, Z.6
Abhyankar, A.7
Israel, L.8
Trevejo-Nunez, G.9
Bogunovic, D.10
Cepika, A.M.11
Macduff, D.12
Chrabieh, M.13
Hubeau, M.14
Bajolle, F.15
Debre, M.16
Mazzolari, E.17
Vairo, D.18
Agou, F.19
Virgin, H.W.20
Bossuyt, X.21
Rambaud, C.22
Facchetti, F.23
Bonnet, D.24
Quartier, P.25
Fournet, J.C.26
Pascual, V.27
Chaussabel, D.28
Notarangelo, L.D.29
Puel, A.30
Israel, A.31
Casanova, J.L.32
Picard, C.33
more..
-
43
-
-
84862761186
-
Diverse ubiquitin signaling in NF-κB activation
-
Iwai K. Diverse ubiquitin signaling in NF-κB activation. Trends Cell Biol. 2012, 22:355-364.
-
(2012)
Trends Cell Biol.
, vol.22
, pp. 355-364
-
-
Iwai, K.1
-
44
-
-
43049162227
-
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
-
Jin L., Williamson A., Banerjee S., Philipp I., Rape M. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 2008, 133:653-665.
-
(2008)
Cell
, vol.133
, pp. 653-665
-
-
Jin, L.1
Williamson, A.2
Banerjee, S.3
Philipp, I.4
Rape, M.5
-
45
-
-
78650300883
-
C-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling
-
Dynek J.N., Goncharov T., Dueber E.C., Fedorova A.V., Izrael-Tomasevic A., Phu L., Helgason E., Fairbrother W.J., Deshayes K., Kirkpatrick D.S., Vucic D. c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010, 29:4198-4209.
-
(2010)
EMBO J.
, vol.29
, pp. 4198-4209
-
-
Dynek, J.N.1
Goncharov, T.2
Dueber, E.C.3
Fedorova, A.V.4
Izrael-Tomasevic, A.5
Phu, L.6
Helgason, E.7
Fairbrother, W.J.8
Deshayes, K.9
Kirkpatrick, D.S.10
Vucic, D.11
-
46
-
-
79953846027
-
Modulation of K11-linkage formation by variable loop residues within UbcH5A
-
Bosanac I., Phu L., Pan B., Zilberleyb I., Maurer B., Dixit V.M., Hymowitz S.G., Kirkpatrick D.S. Modulation of K11-linkage formation by variable loop residues within UbcH5A. J. Mol. Biol. 2011, 408:420-431.
-
(2011)
J. Mol. Biol.
, vol.408
, pp. 420-431
-
-
Bosanac, I.1
Phu, L.2
Pan, B.3
Zilberleyb, I.4
Maurer, B.5
Dixit, V.M.6
Hymowitz, S.G.7
Kirkpatrick, D.S.8
-
47
-
-
0032568792
-
Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
-
Yamaoka S., Courtois G., Bessia C., Whiteside S.T., Weil R., Agou F., Kirk H.E., Kay R.J., Israel A. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 1998, 93:1231-1240.
-
(1998)
Cell
, vol.93
, pp. 1231-1240
-
-
Yamaoka, S.1
Courtois, G.2
Bessia, C.3
Whiteside, S.T.4
Weil, R.5
Agou, F.6
Kirk, H.E.7
Kay, R.J.8
Israel, A.9
-
48
-
-
33645703930
-
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation
-
Wu C.J., Conze D.B., Li T., Srinivasula S.M., Ashwell J.D. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation. Nat. Cell Biol. 2006, 8:398-406.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
49
-
-
77953108542
-
The diversity of ubiquitin recognition: hot spots and varied specificity
-
Winget J.M., Mayor T. The diversity of ubiquitin recognition: hot spots and varied specificity. Mol. Cell 2010, 38:627-635.
-
(2010)
Mol. Cell
, vol.38
, pp. 627-635
-
-
Winget, J.M.1
Mayor, T.2
-
50
-
-
44649166613
-
Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins
-
Wagner S., Carpentier I., Rogov V., Kreike M., Ikeda F., Lohr F., Wu C.J., Ashwell J.D., Dotsch V., Dikic I., Beyaert R. Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins. Oncogene 2008, 27:3739-3745.
-
(2008)
Oncogene
, vol.27
, pp. 3739-3745
-
-
Wagner, S.1
Carpentier, I.2
Rogov, V.3
Kreike, M.4
Ikeda, F.5
Lohr, F.6
Wu, C.J.7
Ashwell, J.D.8
Dotsch, V.9
Dikic, I.10
Beyaert, R.11
-
51
-
-
70350020147
-
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
-
Laplantine E., Fontan E., Chiaravalli J., Lopez T., Lakisic G., Veron M., Agou F., Israel A. NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J. 2009, 28:2885-2895.
-
(2009)
EMBO J.
, vol.28
, pp. 2885-2895
-
-
Laplantine, E.1
Fontan, E.2
Chiaravalli, J.3
Lopez, T.4
Lakisic, G.5
Veron, M.6
Agou, F.7
Israel, A.8
-
52
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation
-
Rahighi S., Ikeda F., Kawasaki M., Akutsu M., Suzuki N., Kato R., Kensche T., Uejima T., Bloor S., Komander D., Randow F., Wakatsuki S., Dikic I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-κB activation. Cell 2009, 136:1098-1109.
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
Ikeda, F.2
Kawasaki, M.3
Akutsu, M.4
Suzuki, N.5
Kato, R.6
Kensche, T.7
Uejima, T.8
Bloor, S.9
Komander, D.10
Randow, F.11
Wakatsuki, S.12
Dikic, I.13
-
53
-
-
61649103747
-
Structural basis for recognition of diubiquitins by NEMO
-
Lo Y.C., Lin S.C., Rospigliosi C.C., Conze D.B., Wu C.J., Ashwell J.D., Eliezer D., Wu H. Structural basis for recognition of diubiquitins by NEMO. Mol. Cell 2009, 33:602-615.
-
(2009)
Mol. Cell
, vol.33
, pp. 602-615
-
-
Lo, Y.C.1
Lin, S.C.2
Rospigliosi, C.C.3
Conze, D.B.4
Wu, C.J.5
Ashwell, J.D.6
Eliezer, D.7
Wu, H.8
-
54
-
-
34548225910
-
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains
-
Abbott D.W., Yang Y., Hutti J.E., Madhavarapu S., Kelliher M.A., Cantley L.C. Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol. Cell. Biol. 2007, 27:6012-6025.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6012-6025
-
-
Abbott, D.W.1
Yang, Y.2
Hutti, J.E.3
Madhavarapu, S.4
Kelliher, M.A.5
Cantley, L.C.6
-
55
-
-
0345826149
-
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
-
Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., Xiao W., Dixit V.M. Bcl10 activates the NF-κB pathway through ubiquitination of NEMO. Nature 2004, 427:167-171.
-
(2004)
Nature
, vol.427
, pp. 167-171
-
-
Zhou, H.1
Wertz, I.2
O'Rourke, K.3
Ultsch, M.4
Seshagiri, S.5
Eby, M.6
Xiao, W.7
Dixit, V.M.8
-
56
-
-
77956627845
-
"Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-κB activation
-
Gautheron J., Courtois G. "Without Ub I am nothing": NEMO as a multifunctional player in ubiquitin-mediated control of NF-κB activation. Cell Mol. Life Sci. 2010, 67:3101-3113.
-
(2010)
Cell Mol. Life Sci.
, vol.67
, pp. 3101-3113
-
-
Gautheron, J.1
Courtois, G.2
-
57
-
-
79961003254
-
A new mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein
-
Hubeau M., Ngadjeua F., Puel A., Israel L., Feinberg J., Chrabieh M., Belani K., Bodemer C., Fabre I., Plebani A., Boisson-Dupuis S., Picard C., Fischer A., Israel A., Abel L., Veron M., Casanova J.L., Agou F., Bustamante J. A new mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein. Blood 2011, 4041-4051.
-
(2011)
Blood
, pp. 4041-4051
-
-
Hubeau, M.1
Ngadjeua, F.2
Puel, A.3
Israel, L.4
Feinberg, J.5
Chrabieh, M.6
Belani, K.7
Bodemer, C.8
Fabre, I.9
Plebani, A.10
Boisson-Dupuis, S.11
Picard, C.12
Fischer, A.13
Israel, A.14
Abel, L.15
Veron, M.16
Casanova, J.L.17
Agou, F.18
Bustamante, J.19
-
58
-
-
0026968499
-
Receptor protein tyrosine kinases and phosphatases
-
Hunter T., Lindberg R.A., Middlemas D.S., Tracy S., van der Geer P. Receptor protein tyrosine kinases and phosphatases. Cold Spring Harb. Symp. Quant. Biol. 1992, 57:25-41.
-
(1992)
Cold Spring Harb. Symp. Quant. Biol.
, vol.57
, pp. 25-41
-
-
Hunter, T.1
Lindberg, R.A.2
Middlemas, D.S.3
Tracy, S.4
van der Geer, P.5
-
59
-
-
79955481873
-
Crystal structure of inhibitor of κB kinase β
-
Xu G., Lo Y.C., Li Q., Napolitano G., Wu X., Jiang X., Dreano M., Karin M., Wu H. Crystal structure of inhibitor of κB kinase β. Nature 2011, 472:325-330.
-
(2011)
Nature
, vol.472
, pp. 325-330
-
-
Xu, G.1
Lo, Y.C.2
Li, Q.3
Napolitano, G.4
Wu, X.5
Jiang, X.6
Dreano, M.7
Karin, M.8
Wu, H.9
-
60
-
-
71149105333
-
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
-
Haas T.L., Emmerich C.H., Gerlach B., Schmukle A.C., Cordier S.M., Rieser E., Feltham R., Vince J., Warnken U., Wenger T., Koschny R., Komander D., Silke J., Walczak H. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol. Cell 2009, 36:831-844.
-
(2009)
Mol. Cell
, vol.36
, pp. 831-844
-
-
Haas, T.L.1
Emmerich, C.H.2
Gerlach, B.3
Schmukle, A.C.4
Cordier, S.M.5
Rieser, E.6
Feltham, R.7
Vince, J.8
Warnken, U.9
Wenger, T.10
Koschny, R.11
Komander, D.12
Silke, J.13
Walczak, H.14
-
61
-
-
84855517985
-
Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
-
Sato Y., Fujita H., Yoshikawa A., Yamashita M., Yamagata A., Kaiser S.E., Iwai K., Fukai S. Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:20520-20525.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 20520-20525
-
-
Sato, Y.1
Fujita, H.2
Yoshikawa, A.3
Yamashita, M.4
Yamagata, A.5
Kaiser, S.E.6
Iwai, K.7
Fukai, S.8
-
62
-
-
27744577296
-
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
-
Shim J.H., Xiao C., Paschal A.E., Bailey S.T., Rao P., Hayden M.S., Lee K.Y., Bussey C., Steckel M., Tanaka N., Yamada G., Akira S., Matsumoto K., Ghosh S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005, 19:2668-2681.
-
(2005)
Genes Dev.
, vol.19
, pp. 2668-2681
-
-
Shim, J.H.1
Xiao, C.2
Paschal, A.E.3
Bailey, S.T.4
Rao, P.5
Hayden, M.S.6
Lee, K.Y.7
Bussey, C.8
Steckel, M.9
Tanaka, N.10
Yamada, G.11
Akira, S.12
Matsumoto, K.13
Ghosh, S.14
-
63
-
-
33751576420
-
Cutting edge: pivotal function of Ubc13 in thymocyte TCR signaling
-
Yamamoto M., Sato S., Saitoh T., Sakurai H., Uematsu S., Kawai T., Ishii K.J., Takeuchi O., Akira S. Cutting edge: pivotal function of Ubc13 in thymocyte TCR signaling. J. Immunol. 2006, 177:7520-7524.
-
(2006)
J. Immunol.
, vol.177
, pp. 7520-7524
-
-
Yamamoto, M.1
Sato, S.2
Saitoh, T.3
Sakurai, H.4
Uematsu, S.5
Kawai, T.6
Ishii, K.J.7
Takeuchi, O.8
Akira, S.9
-
65
-
-
77952336245
-
Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains
-
Zhao S., Ulrich H.D. Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:7704-7709.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 7704-7709
-
-
Zhao, S.1
Ulrich, H.D.2
-
66
-
-
65649115267
-
Recognition and processing of ubiquitin-protein conjugates by the proteasome
-
Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 2009, 78:477-513.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 477-513
-
-
Finley, D.1
|