Hybrid modeling of the crosstalk between signaling and transcriptional networks using ordinary differential equations and multi-valued logic

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1844, Issue 1 PART B, 2014, Pages 289-298

  Khan, Faiz M ^a   Schmitz, Ulf ^a   Nikolov, Svetoslav ^c   Engelmann, David ^b   Pützer, Brigitte M ^b   Wolkenhauer, Olaf ^a,d   Vera, Julio ^a,e  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^c INSTITUTE OF MECHANICS   (Bulgaria)

^d STELLENBOSCH UNIVERSITY   (South Africa)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Cancer; Chemoresistance; E2F1; Feedback loop; Non linear motif; Signaling

Indexed keywords

BIM PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; MICRORNA; MICRORNA 205; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; PROTEIN P73; PUMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR FKHRL1; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; DNA DAMAGE; DNA REPLICATION; GENE CONTROL; GENE TARGETING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SIMULATION; TRANSCRIPTION REGULATION;

CANCER; CHEMORESISTANCE; E2F1; FEEDBACK LOOP; NON-LINEAR MOTIF; SIGNALING;

COMPUTATIONAL BIOLOGY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HUMANS; MODELS, THEORETICAL; NONLINEAR DYNAMICS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSCRIPTION FACTORS;

EID: 84890126626     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2013.05.007     Document Type: Article

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