Chronic antidepressant treatments resulted in altered expression of genes involved in inflammation in the rat hypothalamus

European Journal of Pharmacology

Volumn 721, Issue 1-3, 2013, Pages 158-167

  Alboni, Silvia ^a   Benatti, Cristina ^a   Montanari, Claudia ^a   Tascedda, Fabio ^a   Brunello, Nicoletta ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Antidepressant; Cytokine; Gene expression; Hypothalamus; Inflammation

Indexed keywords

FLUOXETINE; FRACTALKINE; GAMMA INTERFERON; IMIPRAMINE; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PROTEIN S 100; PROTEIN S100A10; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; DRUG TARGETING; FEMALE; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; LONG TERM CARE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SLEEP PATTERN; STRESS;

ANTIDEPRESSANT; CYTOKINE; GENE EXPRESSION; HYPOTHALAMUS; INFLAMMATION;

ANIMALS; ANNEXIN A2; ANTIDEPRESSIVE AGENTS; CYTOKINES; GENE EXPRESSION REGULATION; HYPOTHALAMUS; INFLAMMATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-18; RNA, MESSENGER; S100 PROTEINS; TIME FACTORS;

EID: 84890126492     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.046     Document Type: Article

References (88)

1. O.M. Abdel-Salam, S.M. Nofal, and S.M. El-Shenawy Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat Pharmacological Research 48 2003 157 165 (Pubitemid 36683164)
2. S. Alboni, C. Benatti, G. Capone, D. Corsini, F. Caggia, F. Tascedda, J. Mendlewicz, and N. Brunello Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats European Journal of Pharmacology 643 2010 180 187
3. S. Alboni, D. Cervia, B. Ross, C. Montanari, A.S. Gonzalez, M. Sanchez-Alavez, M.C. Marcondes, D. De Vries, S. Sugama, N. Brunello, J. Blom, F. Tascedda, and B. Conti Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain Journal of Neuroimmunology 214 2009 43 54
4. S. Alboni, D. Cervia, S. Sugama, and B. Conti Interleukin 18 in the CNS Journal of Neuroinflammation 7 2010 9
5. S. Alboni, L. Gibellini, C. Montanari, C. Benatti, S. Benatti, F. Tascedda, N. Brunello, A. Cossarizza, and C.M. Pariante N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-α in human neurons International Journal of Neuropsychopharmacology 2013 1 17
6. S. Alboni, C. Montanari, C. Benatti, J.M. Blom, M.L. Simone, N. Brunello, F. Caggia, G. Guidotti, M.C. Marcondes, M. Sanchez-Alavez, B. Conti, and F. Tascedda Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain Brain, Behavior, and Immunity 25 2011 483 493
7. S. Alboni, F. Tascedda, D. Corsini, C. Benatti, F. Caggia, G. Capone, N. Barden, J.M. Blom, and N. Brunello Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice Neuropharmacology 60 2011 1337 1346
8. B. Alexander, J. Warner-Schmidt, T. Eriksson, C. Tamminga, M. Arango-Lievano, M. Arango-Llievano, S. Ghose, M. Vernov, M. Stavarache, M. Stavarche, S. Musatov, M. Flajolet, P. Svenningsson, P. Greengard, and M.G. Kaplitt Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens Science Translational Medicine 2 2010 54ra76 2010
9. N.L. Baganz, and R.D. Blakely A dialogue between the immune system and brain, spoken in the language of serotonin ACS Chemical Neuroscience 4 2013 48 63
10. C. Benatti, S. Alboni, C. Montanari, F. Caggia, F. Tascedda, N. Brunello, and J.M. Blom Central effects of a local inflammation in three commonly used mouse strains with a different anxious phenotype Behavioural Brain Research 224 2011 23 34
11. C. Benatti, C. Valensisi, J.M. Blom, S. Alboni, C. Montanari, F. Ferrari, E. Tagliafico, J. Mendlewicz, N. Brunello, and F. Tascedda Transcriptional profiles underlying vulnerability and resilience in rats exposed to an acute unavoidable stress Journal of Neuroscience Research 90 2012 2103 2115
12. M.R. Bennett The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain Progress in Neurobiology 93 2011 468 487
13. M. Bianchi, P. Sacerdote, and A.E. Panerai Fluoxetine reduces inflammatory edema in the rat: involvement of the pituitary-adrenal axis European Journal of Pharmacology 263 1994 81 84 (Pubitemid 24290256)
14. N. Brunello, S. Alboni, G. Capone, C. Benatti, J.M. Blom, F. Tascedda, P. Kriwin, and J. Mendlewicz Acetylsalicylic acid accelerates the antidepressant effect of fluoxetine in the chronic escape deficit model of depression International Clinical Psychopharmacology 21 2006 219 225 (Pubitemid 43740299)
15. L. Capuron, and A.H. Miller Immune system to brain signaling: neuropsychopharmacological implications Pharmacology & Therapeutics 130 2011 226 238
16. A. Cattaneo, M. Gennarelli, R. Uher, G. Breen, A. Farmer, K.J. Aitchison, I.W. Craig, C. Anacker, P.A. Zunsztain, P. McGuffin, and C.M. Pariante Candidate genes expression profile associated with antidepressants response in the GENDEP Study: differentiating between baseline 'predictors' and longitudinal 'targets' Neuropsychopharmacology 38 2013 377 385
17. S. Chourbaji, A. Urani, I. Inta, C. Sanchis-Segura, C. Brandwein, M. Zink, M. Schwaninger, and P. Gass IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors Neurobiology of Disease 23 2006 587 594 (Pubitemid 44234095)
18. B. Conti, R. Maier, A.M. Barr, M.C. Morale, X. Lu, P.P. Sanna, G. Bilbe, D. Hoyer, and T. Bartfai Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine Molecular Psychiatry 12 2007 167 189 (Pubitemid 46160982)
19. G. Dagyte, A. Trentani, F. Postema, P.G. Luiten, J.A. Den Boer, C. Gabriel, E. Mocaër, P. Meerlo, and E.A. Van der Zee The novel antidepressant agomelatine normalizes hippocampal neuronal activity and promotes neurogenesis in chronically stressed rats CNS Neuroscience & Therapeutics 16 2010 195 207
20. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: when the immune system subjugates the brain Nature Reviews Neuroscience 9 2008 46 56 (Pubitemid 350295688)
21. R. Dantzer, J.C. O'Connor, M.A. Lawson, and K.W. Kelley Inflammation-associated depression: from serotonin to kynurenine Psychoneuroendocrinology 36 2011 426 436
22. A.H. de Haas, H.R. van Weering, E.K. de Jong, H.W. Boddeke, and K.P. Biber Neuronal chemokines: versatile messengers in central nervous system cell interaction Molecular Neurobiology 36 2007 137 151 (Pubitemid 351360343)
23. W.C. Drevets, J.L. Price, and M.L. Furey Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression Brain Structure & Function 213 2008 93 118
24. DSM-IV Diagnostic and Statistical Manual of Mental Disorders 4th ed. 2003 American Psychiatric Press Washington, DC (Text Revision ed.)
25. R.S. Duman, and B. Voleti Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents Trends in Neurosciences 35 2012 47 56
26. Y.T. Fang, C.F. Lin, C.Y. Wang, R. Anderson, and Y.S. Lin Interferon-γ stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis Journal of Cellular Physiology 227 2012 2775 2787
27. S.P. Gadani, J.C. Cronk, G.T. Norris, and J. Kipnis IL-4 in the brain: a cytokine to remember Journal of Immunology 189 2012 4213 4219
28. J. Gibb, M.C. Audet, S. Hayley, and H. Anisman Neurochemical and behavioral responses to inflammatory immune stressors Frontiers in Bioscience (Scholar Edition) 1 2009 275 295
29. M. Girotti, J.J. Donegan, and D.A. Morilak Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain Psychoneuroendocrinology 36 2011 1164 1174
30. E. Haastrup, J.D. Bukh, C. Bock, M. Vinberg, L.W. Thørner, T. Hansen, T. Werge, L.V. Kessing, and H. Ullum Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events Journal of Affective Disorders 136 2012 134 138
31. N. Hepgul, N. Kodate, J.E. Anderson, M. Henderson, G. Ranjith, M. Hotopf, and C.M. Pariante Understanding clinical risk decision making regarding development of depression during interferon-alpha treatment for hepatitis-C: a qualitative interview study International Journal of Nursing Studies 49 2012 1480 1488
32. H. Himmerich, S. Fulda, A.J. Sheldrick, B. Plümäkers, and L. Rink IFN-gamma reduction by tricyclic antidepressants International Journal of Psychiatry in Medicine 40 2010 413 424
33. T.A. Ignatowski, and R.N. Spengler Cytokines in synaptic function P.C.a.K. Elena, NeuroImmune Biology 2008 Elsevier Amsterdam, The Netherlands 111 145
34. G. Kenis, and M. Maes Effects of antidepressants on the production of cytokines International Journal of Neuropsychopharmacology 5 2002 401 412 (Pubitemid 35470359)
35. M. Kokai, S. Kashiwamura, H. Okamura, K. Ohara, and Y. Morita Plasma interleukin-18 levels in patients with psychiatric disorders Journal of Immunotherapy 25 Suppl 1 2002 S68 S71
36. V. Krishnan, and E.J. Nestler The molecular neurobiology of depression Nature 455 2008 894 902
37. M. Kubera, A.H. Lin, G. Kenis, E. Bosmans, D. van Bockstaele, and M. Maes Anti-Inflammatory effects of antidepressants through suppression of the interferon-gamma/interleukin-10 production ratio Journal of Clinical Psychopharmacology 21 2001 199 206 (Pubitemid 32221058)
38. K.M. Lee, and Y.K. Kim The role of IL-12 and TGF-beta1 in the pathophysiology of major depressive disorder International Immunopharmacology 6 2006 1298 1304
39. Y.H. Lee, S.H. Kim, Y. Kim, Y. Lim, K. Ha, and S.Y. Shin Inhibitory effect of the antidepressant imipramine on NF-κB-dependent CXCL1 expression in TNFα-exposed astrocytes International Immunopharmacology 12 2012 547 555
40. S.M. Lehto, L. Niskanen, K.H. Herzig, T. Tolmunen, A. Huotari, H. Viinamäki, H. Koivumaa-Honkanen, K. Honkalampi, H. Ruotsalainen, and J. Hintikka Serum chemokine levels in major depressive disorder Psychoneuroendocrinology 35 2010 226 232
41. M. Li, and R.M. Ransohoff Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology Progress in Neurobiology 84 2008 116 131
42. D. Liu, Z. Wang, S. Liu, F. Wang, S. Zhao, and A. Hao Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells Neuropharmacology 61 2011 592 599
43. V. Lorenzetti, N.B. Allen, A. Fornito, and M. Yücel Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies Journal of Affective Disorders 117 2009 1 17
44. M. Maes, Z. Fišar, M. Medina, G. Scapagnini, G. Nowak, and M. Berk New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates - Nrf2 activators and GSK-3 inhibitors Inflammopharmacology 20 2012 127 150
45. M. Maes, G. Kenis, M. Kubera, M. De Baets, H. Steinbusch, and E. Bosmans The negative immunoregulatory effects of fluoxetine in relation to the cAMP-dependent PKA pathway International Immunopharmacology 5 2005 609 618 (Pubitemid 40439180)
46. M. Maes, C. Song, A.H. Lin, S. Bonaccorso, G. Kenis, R. De Jongh, E. Bosmans, and S. Scharpé Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion Neuropsychopharmacology 20 1999 370 379 (Pubitemid 29099768)
47. N.J. Marchant, E.Z. Millan, and G.P. McNally The hypothalamus and the neurobiology of drug seeking Cellular and Molecular Life Sciences 69 2012 581 597
48. J.F. Maya Vetencourt, A. Sale, A. Viegi, L. Baroncelli, R. De Pasquale, O.F. O'Leary, E. Castrén, and L. Maffei The antidepressant fluoxetine restores plasticity in the adult visual cortex Science 320 2008 385 388 (Pubitemid 351555663)
49. R.A. Merendino, A.E. Di Rosa, G. Di Pasquale, P.L. Minciullo, C. Mangraviti, A. Costantino, A. Ruello, and S. Gangemi Interleukin-18 and CD30 serum levels in patients with moderate-severe depression Mediators of Inflammation 11 2002 265 267 (Pubitemid 35155470)
50. A.R. Mesquita, M. Correia-Neves, S. Roque, A.G. Castro, P. Vieira, J. Pedrosa, J.A. Palha, and N. Sousa IL-10 modulates depressive-like behavior Journal of Psychiatric Research 43 2008 89 97
51. M. Mihara, M. Hashizume, H. Yoshida, M. Suzuki, and M. Shiina IL-6/IL-6 receptor system and its role in physiological and pathological conditions Clinical Science (London) 122 2012 143 159
52. A.H. Miller, V. Maletic, and C.L. Raison Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biological Psychiatry 65 2009 732 741
53. M. Nibuya, E.J. Nestler, and R.S. Duman Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus Journal of Neuroscience 16 1996 2365 2372 (Pubitemid 26154346)
54. E. Obuchowicz, J. Kowalski, K. Labuzek, R. Krysiak, J. Pendzich, and Z.S. Herman Amitriptyline and nortriptyline inhibit interleukin-1 release by rat mixed glial and microglial cell cultures International Journal of Neuropsychopharmacology 9 2006 27 35 (Pubitemid 43068332)
55. H. Okamura, H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, K. Torigoe, T. Okura, Y. Nukada, and K. Hattori Cloning of a new cytokine that induces IFN-gamma production by T cells Nature 378 1995 88 91
56. C.M. Pariante The glucocorticoid receptor: part of the solution or part of the problem? Journal of Psychopharmacology 20 2006 79 84 (Pubitemid 44576663)
57. C.M. Pariante Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids Annals of the New York Academy of Sciences 1179 2009 144 152
58. R.N. Pechnick, V.M. Chesnokova, A. Kariagina, S. Price, C.J. Bresee, and R.E. Poland Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) gene Neuropsychopharmacology 29 2004 770 776 (Pubitemid 38402484)
59. J. Prickaerts, J. De Vry, J. Boere, G. Kenis, M.S. Quinton, S. Engel, L. Melnick, and R. Schreiber Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex Journal of Molecular Neuroscience 48 2012 167 175
60. Y. Quidé, A.B. Witteveen, W. El-Hage, D.J. Veltman, and M. Olff Differences between effects of psychological versus pharmacological treatments on functional and morphological brain alterations in anxiety disorders and major depressive disorder: a systematic review Neuroscience & Biobehavioral Reviews 36 2012 626 644
61. T.J. Raedler Inflammatory mechanisms in major depressive disorder Current Opinion in Psychiatry 24 2011 519 525
62. B.J. Rollins Chemokines Blood 90 1997 909 928 (Pubitemid 27314123)
63. H.J. Rosen, and R.W. Levenson The emotional brain: combining insights from patients and basic science Neurocase 15 2009 173 181
64. C. Roumestan, A. Michel, F. Bichon, K. Portet, M. Detoc, C. Henriquet, D. Jaffuel, and M. Mathieu Anti-inflammatory properties of desipramine and fluoxetine Respiratory Research 8 2007 35
65. S. Sacre, M. Medghalchi, B. Gregory, F. Brennan, and R. Williams Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors Arthritis & Rheumatism 62 2010 683 693
66. H.D. Schmidt, and R.S. Duman The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior Behavioral pharmacology 18 2007 391 418 (Pubitemid 47356367)
67. B.D. Semple, T. Kossmann, and M.C. Morganti-Kossmann Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks Journal of Cerebral Blood Flow & Metabolism 30 2010 459 473
68. S. Sen, and G. Sanacora Major depression: emerging therapeutics Mount Sinai Journal of Medicine 75 2008 204 225
69. B. Sergi, and I. Penttila Interleukin 18 receptor Journal of Biological Regulators & Homeostatic Agents 18 2004 55 61 (Pubitemid 39193430)
70. R.C. Shelton, J. Claiborne, M. Sidoryk-Wegrzynowicz, R. Reddy, M. Aschner, D.A. Lewis, and K. Mirnics Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression Molecular Psychiatry 16 2011 751 762
71. R.B. Simerly Anatomical substrates of hypothalamic integration G. Paxinos, The Rat Nervous System Third ed. 2004 Elsevier Academic Press San Diego, California, USA 336 369
72. S. Sugama, and B. Conti Interleukin-18 and stress Brain Research Review 58 2008 85 95
73. L. Sutcigil, C. Oktenli, U. Musabak, A. Bozkurt, A. Cansever, O. Uzun, S.Y. Sanisoglu, Z. Yesilova, N. Ozmenler, A. Ozsahin, and A. Sengul Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy Clinical and Developmental Immunology 2007 2007 76396
74. P. Svenningsson, K. Chergui, I. Rachleff, M. Flajolet, X. Zhang, M. El Yacoubi, J.M. Vaugeois, G.G. Nomikos, and P. Greengard Alterations in 5-HT1B receptor function by p11 in depression-like states Science 311 2006 77 80 (Pubitemid 43063061)
75. P. Svenningsson, and P. Greengard p11 (S100A10) - an inducible adaptor protein that modulates neuronal functions Current Opinion in Pharmacology 7 2007 27 32
76. G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nature Reviews Immunology 3 2003 133 146 (Pubitemid 37328691)
77. C.W. Tsao, Y.S. Lin, C.C. Chen, C.H. Bai, and S.R. Wu Cytokines and serotonin transporter in patients with major depression Progress in Neuro-Psychopharmacology & Biological Psychiatry 30 2006 899 905
78. G. Vitale, V. Ruggieri, M. Filaferro, C. Frigeri, S. Alboni, F. Tascedda, N. Brunello, R. Guerrini, C. Cifani, and M. Massi Chronic treatment with the selective NOP receptor antagonist [Nphe 1, Arg 14, Lys 15]N/OFQ-NH 2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats Psychopharmacology (Berlin) 207 2009 173 189
79. F.R. Walker A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression? Neuropharmacology 67 2013 304 317
80. J.L. Warner-Schmidt, E.Y. Chen, X. Zhang, J.J. Marshall, A. Morozov, P. Svenningsson, and P. Greengard A role for p11 in the antidepressant action of brain-derived neurotrophic factor Biological Psychiatry 68 2010 528 535
81. L.L. Williamson, and S.D. Bilbo Chemokines and the hippocampus: a new perspective on hippocampal plasticity and vulnerability Brain Behav. Immun. 30 2013 186 194
82. Y. Wolf, S. Yona, K.W. Kim, and S. Jung Microglia, seen from the CX3CR1 angle Frontiers in Cellular Neuroscience 7 2013 26
83. H. Xu, Z. Chen, J. He, S. Haimanot, X. Li, L. Dyck, and X.M. Li Synergetic effects of quetiapine and venlafaxine in preventing the chronic restraint stress-induced decrease in cell proliferation and BDNF expression in rat hippocampus Hippocampus 16 2006 551 559 (Pubitemid 43942103)
84. Z. You, C. Luo, W. Zhang, Y. Chen, J. He, Q. Zhao, R. Zuo, and Y. Wu Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression Behavioural Brain Research 225 2011 135 141
85. H. Yu, and Z.Y. Chen The role of BDNF in depression on the basis of its location in the neural circuitry Acta Pharmacologica Sinica 32 2011 3 11
86. F. Zheng, X. Zhou, C. Moon, and H. Wang Regulation of brain-derived neurotrophic factor expression in neurons International Journal of Physiology, Pathophysiology and Pharmacology 4 2012 188 200
87. P.A. Zunszain, C. Anacker, A. Cattaneo, L.A. Carvalho, and C.M. Pariante Glucocorticoids, cytokines and brain abnormalities in depression Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 2011 722 729
88. P.A. Zunszain, N. Hepgul, and C.M. Pariante Inflammation and depression Current Topics in Behavioral Neurosciences 2012