Calcium/calmodulin-dependent serine protein kinase is involved in exendin-4-induced insulin secretion in INS-1 cells

Metabolism: Clinical and Experimental

Volumn 63, Issue 1, 2014, Pages 120-126

  Zhu, Zheng Qiu ^a   Wang, Dong ^a   Xiang, Dan ^a   Yuan, Yue Xing ^a   Wang, Yao ^a  

^a SOUTHEAST UNIVERSITY   (China)

Author keywords

CASK; Epac2; GLP 1; PKA

Indexed keywords

ANTIPORTER; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; EXENDIN 4; MESSENGER RNA; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; INSULIN RELEASE; INSULINOMA; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

8-PCPT-2′-O-ME-CAMP-AM; CALCIUM/CALMODULIN-DEPENDENT SERINE PROTEIN KINASE; CAMP; CASK; CYCLIC ADENOSINE MONOPHOSPHATE; EPAC2; ESCA-AM; EX-4; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP-2; EXENDIN-4; GLP-1; GLUCAGON-LIKE PEPTIDE-1; GLUCOSE-STIMULATED INSULIN SECRETION; GSIS; H-89; N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE; PKA; PROTEIN KINASE A.;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, TYPE 2; GENE KNOCKDOWN TECHNIQUES; GLUCAGON-LIKE PEPTIDE 1; GUANYLATE KINASE; HYPOGLYCEMIC AGENTS; INSULIN; INSULINOMA; MICROSCOPY, FLUORESCENCE; PANCREATIC NEOPLASMS; PEPTIDES; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VENOMS;

EID: 84890125168     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.09.009     Document Type: Article

References (34)

1. S. Mojsov, G.C. Weir, and J.F. Habener Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas J Clin Invest 79 2 1987 616 619
2. B. Kreymann, G. Williams, and M.A. Ghatei Glucagon-like peptide-1 7-36: a physiological incretin in man Lancet 2 8571 1987 1300 1304
3. J. Eng, W.A. Kleinman, and L. Singh Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas J Biol Chem 267 11 1992 7402 7405
4. A. Shalev, J.J. Holst, and U. Keller Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man Eur J Clin Invest 27 1 1997 10 16
5. D.M. Kendall, M.C. Riddle, and J. Rosenstock Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea Diabetes Care 28 5 2005 1083 1091
6. Y.P. Hsueh The role of the MAGUK protein CASK in neural development and synaptic function Curr Med Chem 13 16 2006 1915 1927
7. Y.P. Hsueh Calcium/calmodulin-dependent serine protein kinase and mental retardation Ann Neurol 66 4 2009 438 443
8. S. Butz, M. Okamoto, and T.C. Sudhof A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain Cell 94 6 1998 773 782
9. J.B. Slawson, E.A. Kuklin, and A. Ejima Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains Genetics 187 1 2011 171 184
10. M.A. Zordan, M. Massironi, and M.G. Ducato Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release J Neurophysiol 94 2 2005 1074 1083
11. Y. Hori, X. Gu, and X. Xie Differentiation of insulin-producing cells from human neural progenitor cells PLoS Med 2 4 2005 e103
12. E.J. Rulifson, S.K. Kim, and R. Nusse Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes Science 296 5570 2002 1118 1120
13. K. Fujimoto, T. Shibasaki, and N. Yokoi Piccolo, a Ca2 + sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis J Biol Chem 277 52 2002 50497 50502
14. M. Ohara-Imaizumi, T. Ohtsuka, and S. Matsushima ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy Mol Biol Cell 16 7 2005 3289 3300
15. R. Regazzi, C.B. Wollheim, and J. Lang VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2 +)-but not for GTP gamma S-induced insulin secretion EMBO J 14 12 1995 2723 2730
16. A.T. Suckow, D. Comoletti, and M.A. Waldrop Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion Endocrinology 149 12 2008 6006 6017
17. K. Tabuchi, T. Biederer, and S. Butz CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein J Neurosci 22 11 2002 4264 4273
18. A.R. Cohen, D.F. Woods, and S.M. Marfatia Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells J Cell Biol 142 1 1998 129 138
19. X. Han, Y. Sun, and S. Scott Tissue inhibitor of metalloproteinase-1 prevents cytokine-mediated dysfunction and cytotoxicity in pancreatic islets and beta-cells Diabetes 50 5 2001 1047 1055
20. H.J. Zhang, T.F. Walseth, and R.P. Robertson Insulin secretion and cAMP metabolism in HIT cells. Reciprocal and serial passage-dependent relationships Diabetes 38 1 1989 44 48
21. T. Chijiwa, A. Mishima, and M. Hagiwara Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells J Biol Chem 265 9 1990 5267 5272
22. O.G. Chepurny, C.A. Leech, and G.G. Kelley Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM J Biol Chem 284 16 2009 10728 10736
23. M. Asfari, D. Janjic, and P. Meda Establishment of 2-mercaptoethanol- dependent differentiated insulin-secreting cell lines Endocrinology 130 1 1992 167 178
24. D.J. Drucker, J. Philippe, and S. Mojsov Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line Proc Natl Acad Sci U S A 84 10 1987 3434 3438
25. T.N. Huang, H.P. Chang, and Y.P. Hsueh CASK phosphorylation by PKA regulates the protein-protein interactions of CASK and expression of the NMDAR2b gene J Neurochem 112 6 2010 1562 1573
26. K.P. Knoch, R. Meisterfeld, and S. Kersting cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells Cell Metab 3 2 2006 123 134
27. Y.P. Hsueh, T.F. Wang, and F.C. Yang Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2 Nature 404 6775 2000 298 302
28. U.S. Jhala, G. Canettieri, and R.A. Screaton cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2 Genes Dev 17 13 2003 1575 1580
29. J.F. List, and J.F. Habener Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cells Am J Physiol Endocrinol Metab 286 6 2004 E875 E881
30. H. Kasai, T. Suzuki, and T.T. Liu Fast and cAMP-sensitive mode of Ca(2 +)-dependent exocytosis in pancreatic beta-cells Diabetes 51 Suppl 1 2002 S19 S24
31. J. de Rooij, F.J. Zwartkruis, and M.H. Verheijen Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Nature 396 6710 1998 474 477
32. H. Kawasaki, G.M. Springett, and N. Mochizuki A family of cAMP-binding proteins that directly activate Rap1 Science 282 5397 1998 2275 2279
33. G.G. Holz Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell Diabetes 53 1 2004 5 13
34. S. Seino, H. Takahashi, and W. Fujimoto Roles of cAMP signalling in insulin granule exocytosis Diabetes Obes Metab 11 Suppl 4 2009 180 188