A multifunctional protein EWS regulates the expression of Drosha and microRNAs

Cell Death and Differentiation

Volumn 21, Issue 1, 2014, Pages 136-145

  Kim, K Y ^a   Hwang, Y J ^a   Jung, M K ^a   Choe, J ^b   Kim, Y ^a   Kim, S ^a   Lee, C J ^a   Ahn, H ^a   Lee, J ^c   Kowall, N W ^c   Kim, Y K ^b   Kim, J I ^d   Lee, S B ^e   Ryu, H ^c,f  

^a Seoul National University   (South Korea)

^b Korea University   (South Korea)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Seoul National University College of Medicine   (South Korea)

^e TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Korea Institute of Science and Technology   (South Korea)

Author keywords

CTGF; dermal development; Drosha; EWS; microRNA

Indexed keywords

COLLAGEN TYPE 4; COLLAGEN TYPE 4 ALPHA 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR RECEPTOR 2; MICRORNA; MICRORNA 18B; MICRORNA 29B; MYOTONIC DYSTROPHY PROTEIN KINASE; PROTEIN; PROTEIN DROSHA; RNA BINDING PROTEIN EWS; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOGENESIS; CELL FRACTIONATION; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; EXON; FIBROBLAST; GENE SILENCING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRON; MICROARRAY ANALYSIS; MICROPROCESSOR; MORPHOGENESIS; MOUSE; NISSL STAINING; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UPREGULATION;

MUS;

ANIMALS; CELL LINE; COLLAGEN TYPE IV; CONNECTIVE TISSUE GROWTH FACTOR; DOWN-REGULATION; MICE; MICE, KNOCKOUT; MICRORNAS; RIBONUCLEASE III; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-BINDING PROTEIN EWS; UP-REGULATION;

EID: 84890116155     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.144     Document Type: Article

References (29)

1. Erkizan HV, Uversky VN, Toretsky JA. Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma. Clin Cancer Res 2010; 16: 4077-4083.
2. Rossow KL, Janknecht R. The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res 2001; 61: 2690-2695.
3. Araya N, Hirota K, Shimamoto Y, Miyagishi M, Yoshida E, Ishida J et al. Cooperative interaction of EWS with CREB-binding protein selectively activates hepatocyte nuclear factor 4-mediated transcription. J Biol Chem 2003; 278: 5427-5432.
4. Kovar H. Jekyll and Hyde: The two faces of the FUS/EWS/TAF15 protein family. Sarcoma 2011; 2011: 1-13.
5. Lee J, Rhee BK, Bae GY, Han YM, Kim J. Stimulation of Oct-4 activity by Ewing's sarcoma protein. Stem Cells 2005; 23: 738-751.
6. Janknecht R. EWS-ETS oncoproteins: The linchpins of Ewing tumors. Gene 2005; 363: 1-14.
7. Li H, Watford W, Li C, Parmelee A, Bryant MA, Deng C et al. Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. J Clin Invest 2007; 117: 1314-1323.
8. Cho J, Shen H, Yu H, Li H, Cheng T, Lee SB et al. Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood 2011; 117: 1156-1166.
9. Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development 2004; 131: 1619-1628.
10. Abreu-Velez AM, Howard MS. Collagen IV in normal skin and in pathological processes. N Am J Med Sci 2012; 4: 1-8.
11. Mazaud Guittot S, Verot A, Odet F, Chauvin MA, le Magueresse-Battistoni B. A comprehensive survey of the laminins and collagens type IV expressed in mouse Leydig cells and their regulation by LH/hCG. Reproduction 2008; 135: 479-488.
12. Hertel M, Tretter Y, Alzheimer C, Werner S. Connective tissue growth factor: A novel player in tissue reorganization after brain injury? Eur J Neurosci 2000; 12: 376-380.
13. Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy? Matrix Biol 2002; 21: 473-482.
14. Chen Y, Abraham DJ, Shi-Wen X, Pearson JD, Black CM, Lyons KM et al. CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell 2004; 15: 5635-5646.
15. Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH et al. Posttranscriptional crossregulation between Drosha and DGCR8. Cell 2008; 136: 75-84.
16. Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004; 18: 3016-3027.
17. Liu Y, Taylor NE, Lu L, Usa K, Cowley AW Jr, Ferreri NR et al. Renal medullary microRNAs in Dahl salt-sensitive rats: MiR-29b regulates several collagens and related genes. Hypertension 2010; 55: 974-982.
18. Teta M, Choi YS, Okegbe T, Wong G, Tam OH, Chong MM et al. Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development 2012; 139: 1405-1416.
19. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N et al. The microprocessor complex mediates the genesis of microRNAs. Nature 2004; 432: 235-240.
20. Van Almen GC, Verhesen W, van Leeuwen RE, van de Vrie M, Eurlings C, Schellings MW et al. MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure. Aging Cell 2011; 10: 769-779.
21. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415-419.
22. Lee Y, Jeon K, Lee JT, Kim S, Kim VN. MicroRNA maturation: Stepwise processing and subcellular localization. EMBO J 2002; 21: 4663-4670.
23. Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, Yeom KH et al. Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex. Cell 2006; 125: 887-901.
24. Cushing L, Kuang PP, Qian J, Shao F, Wu J, Little F et al. miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol 2011; 45: 287-294.
25. Wu TD, Nacu S. Fast and SNP-Tolerant detection of complex variants and splicing in short reads. Bioinformatics 2010; 26: 873-881.
26. Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008; 5: 621-628.
27. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
28. Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics 2011; 27: 431-432.
29. Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A et al. STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 2013; 41: D808-D815.