Connective tissue growth factor: A novel player in tissue reorganization after brain injury?

European Journal of Neuroscience

Volumn 12, Issue 1, 2000, Pages 376-380

  Hertel, Moritz ^a   Tretter, Yvonne ^b   Alzheimer, Christian ^b   Werner, Sabine ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Collagen; Fibronectin; Hippocampus; Kainic acid; Mouse

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; KAINIC ACID; MESSENGER RNA; MITOGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GLIA CELL; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR FORMATION;

ANIMALS; BRAIN INJURIES; FIBRONECTINS; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; GROWTH SUBSTANCES; HIPPOCAMPUS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL; TIME FACTORS;

EID: 0033956408     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00930.x     Document Type: Article

References (25)

1. Ben-Ari, Y. (1985) Limbic seizure and hrain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience, 14, 375-403.
2. Bradham, D.M., Igarashi, A., Potter, R.L. & Grotendorst, G.R. (1991) Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J. Cell Biol., 114, 1285-1294.
3. Brigstock, D.R. (1999) The connective tissue growth factor/cysteine-rich 61/ nephroblastoma overexpressed (CCN) family. Endocrine Rev., 20, 189-206.
4. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 62, 156-159.
5. Dammeier, J., Beer, H.-D., Brauchle, M. & Werner, S. (1998a) Dexamethasone is a novel potent inducer of connective tissue growth factor expression: implications for glucocorticoid therapy. J. Biol. Chem., 273, 18185-18190.
6. Dammeier, J., Brauchle, M., Falk, W., Grotendorst, G.R. & Werner, S. (1998b) Connective tissue growth factor: a novel regulator of mucosal repair and fibrosis in inflammatory bowel disease? Int. J. Biochem. Cell. Biol., 30, 909-922.
7. Faherty, C.J., Xanthoudakis, S. & Smeyne, R.J. (1999) Caspase-3-dependent neuronal death in the hippocampus following kainic acid treatment. Brain Res. Mol. Brain Res., 70, 159-163.
8. Frazier, K., Williams, S., Kothapalli, D., Klapper. H. & Grotendorst, G.R. (1996) Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J. Invest. Dermatol., 107, 404-411.
9. Grotendorst, G.R. (1997) Identification and development of novel antifibrotic agents. Exp. Opin. Invest. Drugs, 6, 777-781.
10. Igarashi, A., Okochi, H., Bradham, D.M. & Grotendorst, G.R. (1993) Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol. Cell. Biol, 4, 637-645.
11. Igarashi, A., Nashiro, J., Kikuchi, K., Sato, S., Ihn, H., Grotendorst, G.R. & Takehara, K. (1995) Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J. Invest. Dermatol., 105, 280-284.
12. Igarashi, A., Nashiro, K., Kikuchi, K., Sato, S., Ihn, H., Fujimoto, M., Grotendorst, G.R. & Takehara, K. (1996) Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J. Invest. Dermatol., 106, 729-733.
13. Ito, Y., Aten, J., Bende, R.J., Oemar, B.S., Rabelink, T.J., Weening, J.J. & Goldschmeding, R. (1998) Expression of connective tissue growth factor in human renal fibrosis. Kidney Int., 53, 853-861.
14. Kireeva, M.L., Latinki, B.V., Kolesnikova, T.V., Chen, C.-C., Yang, G.P., Abler, A.S. & Lau, L.F. (1997) Cyr61 and Fisp12 are both ECM-associated signalling molecules: activities, metabolism, and localization during development. Exp. Cell Res., 233, 63-77.
15. Kothapalli, D., Frazier, K.S., Welply, A., Segarini, P.R. & Grotendorst, G.R. (1997) Transforming growth factor β induces anchorage-independent growth of NRK fibroblasts via a connective tissue growth factor-dependent pathway. Cell Growth Differ., 8, 61-68.
16. Kothapalli, D., Hayashi, N. & Grotendorst, G.R. (1998) Inhibition of TGF-β-stimulated CTGF gene expression and anchorage-independent growth by cAMP identifies a CTGF-dependent restriction point in the cell cycle. FASEB J., 12, 1151-1161.
17. Lasky, J.A., Ortiz, L.A., Tonthat, B., Hoyle, G.W., Corti, M., Athas, G., Lungarella, G., Brody, A. & Friedman, M. (1998) Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am. J. Physiol., 275, L365-L371.
18. Logan, A., Berry, M., Gonzalez, A.M., Frautschy, S.A., Sporn, M.B. & Baird, A. (1994a) Effects of transforming growth factor β1 on scar production in the injured central nervous system of the rat. Eur. J. Neurosci., 6, 355-363.
19. Logan, A., Oliver, J.J. & Berry, M. (1994b) Growth factors in CNS repair and regeneration. Progr. Growth Factor Res., 5, 379-405.
20. Morgan, T.E., Nichols, N.R., Pasinetti, G.M. & Finch, C.E. (1993) TGF-β1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration. Exp. Neurol., 120, 291-301.
21. Niquet, J., Jorquera, I., Ben-Ari, Y. & Represa, A. (1994) Proliferative astrocytes may express fibronectin-like protein in the hippocampus of epileptic rats. Neurosci. Lett., 180, 13-16.
22. Oemar, B.S., Werner, A., Garnier, J.-M., Do, D.-D., Godoy, N., Nauck, M., März, W., Rupp, J., Pech, M. & Lüscher, T.F. (1997) Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation, 95, 831-839.
23. Stichel, C.C. & Muller, H.W. (1998) The CNS lesion scar new vistas on an old regeneration barrier. Cell Tissue Res., 294, 1-9.
24. Tretter, Y.P., Munz, B., Hübner, G., ten Bruggencate, G., Werner, S. & Alzheimer, C. (1996) Strong induction of activin expression after hippocampal lesion. Neuroreport, 7, 1819-1823.
25. Werner, S., Peters, K.G., Longaker, M.T., Fuller-Pace, F., Banda, M. & Williams, L.T. (1992) Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc. Natl Acad. Sci. USA, 89, 6896-6900.