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Volumn 20, Issue 6, 2013, Pages 539-546

An update on the recent literature on sickle cell bone disease

Author keywords

Bone disease; Chronic pain; Osteonecrosis; Osteopenia; Osteoporosis; Sickle; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ANNEXIN; C REACTIVE PROTEIN; HYDROXYUREA; LIPOCORTIN 2; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D;

EID: 84890115995     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/01.med.0000436192.25846.0b     Document Type: Review
Times cited : (44)

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    • Musculoskeletal pain, profile and quality of life of individuals with sickle cell disease
    • This study highlights the public health consequences of daily chronic pain in SCD as significantly impacting the quality of life in the domains of physical functioning, mental and emotional wellbeing
    • Ohara DG, Ruas G, Castro SS, et al. Musculoskeletal pain, profile and quality of life of individuals with sickle cell disease. Rev Bras Fisioter 2012; 16:431-438. This study highlights the public health consequences of daily chronic pain in SCD as significantly impacting the quality of life in the domains of physical functioning, mental and emotional wellbeing.
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    • A review of the literature on the multiple dimensions of chronic pain in adults with sickle cell disease
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    • Psychological therapies for sickle cell disease and pain
    • This comprehensive review of the use of psychological therapies in sickle cell disease demonstrates limited evidence to their efficacy and a significant need for adequately powered randomized studies to quantify the benefit of specific interventions
    • Anie KA, Green J. Psychological therapies for sickle cell disease and pain. Cochrane Database Syst Rev 2012; 2:CD001916. This comprehensive review of the use of psychological therapies in sickle cell disease demonstrates limited evidence to their efficacy and a significant need for adequately powered randomized studies to quantify the benefit of specific interventions.
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    • Orofacial manifestations in patients with sickle cell disease
    • This review of the literature on orofacial complications of sickle cell disease highlights the importance of maintaining adequate oral health by regular screening to prevent potential clinically significant complications and emergencies
    • Javed F, Correa FO, Nooh N, et al. Orofacial manifestations in patients with sickle cell disease. Am J Med Sci 2013; 345:234-237. This review of the literature on orofacial complications of sickle cell disease highlights the importance of maintaining adequate oral health by regular screening to prevent potential clinically significant complications and emergencies.
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    • Javed, F.1    Correa, F.O.2    Nooh, N.3
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    • Quantitative MRI analysis of craniofacial bone marrow in patients with sickle cell disease
    • The results of this study suggests the utility of qualitative MRI imaging in monitoring bone marrow volume as an index of disease severity, which may be useful in monitoring the efficacy of treatments for sickle cell disease and other chronic anemias
    • Elias EJ, Liao JH, Jara H, et al. Quantitative MRI analysis of craniofacial bone marrow in patients with sickle cell disease. AJNR Am J Neuroradiol 2013; 34:622-627. The results of this study suggests the utility of qualitative MRI imaging in monitoring bone marrow volume as an index of disease severity, which may be useful in monitoring the efficacy of treatments for sickle cell disease and other chronic anemias.
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    • Elias, E.J.1    Liao, J.H.2    Jara, H.3
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    • QMRI relaxometry of mandibular bone marrow: A monomodal distribution in sickle cell disease
    • This study describes a monomodal distribution of T1 and T2 quantitative MRI histograms of mandibular bone in sickle cell disease that confirms the persistence of red marrow in the mandible compared to controls
    • Liao JH, Jara H, Nadgir R, et al. qMRI relaxometry of mandibular bone marrow: a monomodal distribution in sickle cell disease. J Magn Reson Imaging 2013; 37:1182-1188. This study describes a monomodal distribution of T1 and T2 quantitative MRI histograms of mandibular bone in sickle cell disease that confirms the persistence of red marrow in the mandible compared to controls.
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    • Excellent results and minimal complications of total hip arthroplasty in sickle cell hemoglobinopathy at mid-term follow-up using cementless prosthetic components
    • This is a sentinel study that challenges the historical dogma that discouraged total hip arthroplasty as early treatment for symptomatic advanced osteonecrosis in sickle cell disease. It clearly demonstrates similar longevity and low complication rates for THA in both sickle cell and nonsickle cell patient groups with the use of cementless prosthesis and comprehensive medical management
    • Issa K, Naziri Q, Maheshwari AV, et al. Excellent results and minimal complications of total hip arthroplasty in sickle cell hemoglobinopathy at mid-term follow-up using cementless prosthetic components. J Arthroplasty 2013; 28:1693-1698. This is a sentinel study that challenges the historical dogma that discouraged total hip arthroplasty as early treatment for symptomatic advanced osteonecrosis in sickle cell disease. It clearly demonstrates similar longevity and low complication rates for THA in both sickle cell and nonsickle cell patient groups with the use of cementless prosthesis and comprehensive medical management.
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    • The natural progression of symptomatic humeral head osteonecrosis in adults with sickle cell disease
    • The epidemiology and natural history of humeral head osteonecrosis is described as similar to that of femoral head osteonecrosis in sickle cell disease
    • Poignard A, Flouzat-Lachaniette CH, Amzallag J, et al. The natural progression of symptomatic humeral head osteonecrosis in adults with sickle cell disease. J Bone Joint Surg Am 2012; 94:156-162. The epidemiology and natural history of humeral head osteonecrosis is described as similar to that of femoral head osteonecrosis in sickle cell disease.
    • (2012) J. Bone. Joint. Surg. Am. , vol.94 , pp. 156-162
    • Poignard, A.1    Flouzat-Lachaniette, C.H.2    Amzallag, J.3
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    • Treatment for avascular necrosis of bone in people with sickle cell disease
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