High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: Results of a randomized double blind pilot study

British Journal of Haematology

Volumn 159, Issue 2, 2012, Pages 211-215

  Osunkwo, Ifeyinwa ^a,b   Ziegler, Thomas R ^b   Alvarez, Jessica ^b   McCracken, Courtney ^b   Cherry, Korin ^a   Osunkwo, Chinyere E ^a   Ofori Acquah, Solomon F ^a,b   Ghosh, Samit ^b   Ogunbobode, Adeolu ^b   Rhodes, Jim ^a   Eckman, James R ^b,c   Dampier, Carlton ^a,b   Tangpricha, Vin ^b  

^a CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GRADY MEMORIAL HOSPITAL   (United States)

Author keywords

Chronic pain; Paediatrics; Quality of life; Sickle cell; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; PLACEBO; VITAMIN D;

ADOLESCENT; ARTICLE; CHILD; CHRONIC PAIN; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; HUMAN; MALE; PHYSICAL ACTIVITY; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SICKLE CELL ANEMIA; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; CALCIFEDIOL; CHILD; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; PAIN; PROSPECTIVE STUDIES; VITAMIN D;

EID: 84866867777     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12019     Document Type: Article

References (15)

1. Atherton, K., Berry, D.J., Parsons, T., Macfarlane, G.J.M., Power, C. & Hyppönen, E. (2009) Vitamin D and widespread pain in a white middle aged British population: evidence from a cross sectional population survey. Annals of the Rheumatic Diseases, 68, 817-822.
2. Dampier, C., Ely, E., Brodecki, D. & O'Neal, P. (2002) Home management of pain in sickle cell disease: a daily diary study in children and adolescents. Journal of Pediatric Hematology/oncology, 24, 643-647.
3. Dampier, C., Lieff, S., LeBeau, P., Rhee, S., McMurray, M., Rogers, Z., Smith-Whitley, K. & Wang, W. (2010) Health-related quality of life in children with sickle cell disease: a report from the Comprehensive Sickle Cell Centers Clinical Trial Consortium. Pediatric Blood & Cancer, 55, 485-494.
4. Gloth, F. & Greenough, W. (2004) Vitamin D deficiency as a contributor to multiple forms of chronic pain. Mayo Clinic Proceedings, 79, 696-699.
5. Goodman, B., Artz, N., Radford, B. & Chen, I. (2010) Prevalence of vitamin D deficiency in adults with sickle cell disease. Journal of the National Medical Association, 102, 332-335.
6. Holick, M.F. (2006) High prevalence of vitamin D inadequacy and implications for health. Mayo Clinic Proceedings, 81, 353-373.
7. Holick, M.F., Binkley, N.C., Bischoff-Ferrari, H.A., Gordon, C., Hanley, D., Heaney, R., Murad, M. & Weaver, C. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 96, 1911-1930.
8. Lofti, A., Abdel-Asser, A., Hamdy, A., Omran, A. & El-Rehany, M. (2007) Hypovitaminosis D in female patients with chronic low back pain. Clinical Rheumatology, 26, 1895-1901.
9. McClish, D., Smith, W., Dahman, B., Levenson, J., Roverts, J., Penberthy, L., Aisiku, I., Roseff, S. & Bovjerg, V. (2009) Pain site frequency and location in sickle cell disease: the PiSCES project. Pain, 145, 246-251.
10. Osunkwo, I. (2011) Complete resolution of sickle cell chronic pain with high dose vitamin D therapy: a case report and review of the literature. Journal of Pediatric Hematology/oncology, 33, 549-551.
11. Osunkwo, I., Hodgman, E.I., Cherry, K., Dampier, C., Eckman, J., Ziegler, T., Ofori-Acquah, S. & Tangrpicha, V. (2011) Vitamin D deficiency and chronic pain in sickle cell disease. British Journal of Haematology, 153, 538-540.
12. Reginato, A.J., Falasca, G.F., Pappu, R., McKnight, B. & Agha, A. (1999) Musculoskeletal manifestations of osteomalacia: report of 26 cases and literature review. Seminars in Arthritis and Rheumatism, 28, 287-304.
13. Smith, W.R. & Scherer, M. (2010) Sickle-cell pain: advances in epidemiology and etiology. American Society of Hematology Education Program, 2010, 409-415.
14. Straube, S., Derry, S., Moore, R. & McQuay, H. (2010) Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database Systematic Review, 1, CD007771.
15. van Tuijn, C.F., van Beers, E.J., Schnog, J.J. & Biemond, B.J. (2010) Pain rate and social circumstances rather than cumulative organ damage determine the quality of life in adults with sickle cell disease. American Journal of Hematology, 85, 532-535.