HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-β mediated renal fibrosis in obstructive uropathy

Journal of Urology

Volumn 191, Issue 1, 2014, Pages 242-252

  Manson, Scott R ^a   Song, Joseph B ^a   Hruska, Keith A ^b   Austin, Paul F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS CHILDREN S HOSPITAL   (United States)

Author keywords

bone morphogenetic protein 7; fibrosis; histone deacetylase inhibitors; kidney; ureteral obstruction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; COLLAGEN TYPE 1 ALPHA; DORSOMORPHIN; HISTONE DEACETYLASE; HISTONE H3; OSTEOGENIC PROTEIN 1; PROTEIN INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRICHOSTATIN A; UNCLASSIFIED DRUG; COLLAGEN 1 TYPE A1; COLLAGEN TYPE 1; HISTONE DEACETYLASE INHIBITOR; RECOMBINANT OSTEOGENIC PROTEIN 1; SMAD PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMATIN; CHROMATIN CONDENSATION; CONTROLLED STUDY; HISTONE ACETYLATION; KIDNEY CELL; KIDNEY FIBROSIS; KIDNEY INJURY; MOUSE; NONHUMAN; OBSTRUCTIVE UROPATHY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; URETER OBSTRUCTION; BINDING SITE; CELL DIFFERENTIATION; CELL POPULATION; DEACETYLATION; ENZYME INHIBITION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MYOFIBROBLAST; OBSTRUCTION-INDUCED RENAL FIBROSIS; PATHOGENESIS; PROMOTER REGION; UPREGULATION;

BMP-7; BONE MORPHOGENETIC PROTEIN 7; BONE MORPHOGENIC PROTEIN 7; COLIΑ1; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROSIS; GAPDH; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; HDAC; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITORS; IMCD; INNER MEDULLARY COLLECTING DUCT; KIDNEY; PCR; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE-PCR; RT-PCR; SMA- AND MAD-RELATED PROTEIN; SMAD; TGF-Β; TRANSFORMING GROWTH FACTOR-Β; TRICHOSTATIN A; TSA; TYPE I COLLAGEN, Α1 CHAIN; UNILATERAL URETERAL OBSTRUCTION; URETERAL OBSTRUCTION; UUO; Α-SMA; Α-SMOOTH MUSCLE ACTIN;

ANIMALS; BONE MORPHOGENETIC PROTEIN 7; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FIBROSIS; HISTONE DEACETYLASES; KIDNEY DISEASES; MICE; MICE, INBRED C57BL; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; URETERAL OBSTRUCTION;

EID: 84890114778     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.06.110     Document Type: Article

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