Localized expression of human BMP-7 by BM-MSCs enhances renal repair in an in vivo model of ischemia-reperfusion injury

Genes to Cells

Volumn 17, Issue 1, 2012, Pages 53-64

  Zhen Qiang, Fang ^a   Bing Wei, Ye ^a   Yong Liang, Liu ^a   Xiang Wei, Wang ^a   Shan Hong, Yi ^a   Yuan Ning, Zhang ^a   Wei Sheng, Jia ^a   Wei, Chen ^a   Ye, Gang ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; MALONALDEHYDE; OSTEOGENIC PROTEIN 1; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE THERAPY; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY PERFUSION; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY;

ANIMALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 7; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; HUMANS; KIDNEY; MALONDIALDEHYDE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RABBITS; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

ORYCTOLAGUS CUNICULUS;

EID: 84855171925     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2011.01572.x     Document Type: Article

References (36)

1. Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M. & Chopp, M. (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32, 1005-1011.
2. Esson, M.L. & Schrier, R.W. (2002) Diagnosis and treatment of acute tubular necrosis. Ann. Intern. Med. 137, 744-752.
3. Geeraerts, M.D., Ronveaux-Dupal, M.F., Lemasters, J.J. & Herman, B. (1991) Cytosolic free Ca2+ and proteolysis in lethal oxidative injury in endothelial cells. Am. J. Physiol. 261, C889-C896.
4. Gobe, G., Willgoss, D., Hogg, N., Schoch, E. & Endre, Z. (1999) Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury. Kidney Int. 56, 1299-1304.
5. Jiang, Y., Jahagirdar, B.N., Reinhardt, R.L., et al. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418, 41-49.
6. Kadkhodaee, M., Endre, H.Z., Towner, A.R. & Cross, M. (1995) Hydroxyl radical generation following ischemia-reperfusion in cell-free perfused rat kidney. Biochem. Biophys. Acta. 1243, 169-174.
7. Kale, S., Karihaloo, A., Clark, P.R., Kashgarian, M., Krause, D.S. & Cantley, L.G. (2003) Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. J. Clin. Invest. 112, 42-49.
8. Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., Kato, K., Honmou, O., Houkin, K., Date, I. & Hamada, H. (2004) BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model. Mol. Ther. 9, 189-197.
9. Lee, R.H., Seo, M.J., Reger, R.L., Spees, J.L., Pulin, A.A., Olson, S.D. & Prockop, D.J. (2006) Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc. Natl Acad. Sci. USA 103, 17438-17443.
10. Li, T., Surendran, K., Zawaideh, M.A., Mathew, S. & Hruska, K.A. (2004) Bone morphogenetic protein-7: a novel treatment for chronic renal and bone disease. Curr. Opin. Nephrol. Hypertens. 13, 417-422.
11. Lien, Y.H., Lai, L.W. & Silva, A.L. (2003) Pathogenesis of renal ischemia/reperfusion injury: lessons from knockout mice. Life Sci. 74, 543-552.
12. Manson, S.R., Niederhoff, R.A., Hruska, K.A. & Austin, P.F. (2011) The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury. J. Urol. 185, 2523-2530.
13. Marumo, T., Hishikawa, K., Yoshikawa, M. & Fujita, T. (2008) Epigenetic regulation of BMP7 in the regenerative response to ischemia. J. Am. Soc. Nephrol. 19, 1311-1320.
14. Mollura, D.J., Hare, J.M. & Rabb, H. (2003) Stem - cell therapy for renal diseases. Am. J. Kidney Dis. 42, 891-905.
15. Moran, S.M. & Myers, B.D. (1985) Pathophysiology of protracted acute renal failure in man. J. Clin. Invest. 76, 1440-1448.
16. Munoz, J.R., Stoutenger, B.R., Robinson, A.P., Spees, J.L. & Prockop, D.J. (2005) Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc. Natl Acad. Sci. USA 102, 18171-18176.
17. Myers, B.D. & Moran, S.M. (1986) Hemodynamically mediated acute renal failure. N. Engl. J. Med. 314, 97-105.
18. Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Tamura, A., Kirino, T. & Nakafuku, M. (2002) Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110, 429-441.
19. Nath, K.A. & Norby, S.M. (2000) Reactive oxygen species and acute renal failure. Am. J. Med. 109, 665-678.
20. Orlic, D. (2002) Stem cell repair in ischemic heart disease: an experimental model. Int. J. Hematol. 76, 144-145.
21. Otani, A., Kinder, K., Ewalt, K., Otero, F.J., Schimmel, P. & Friedlander, M. (2002) Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat. Med. 8, 1004-1010.
22. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S. & Marshak, D.R. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147.
23. Rabb, H., O'Meara, Y.M., Maderna, P., Coleman, P. & Brady, H.R. (1997) Leukocytes, cell adhesion molecules and ischemic acute renal failure. Kidney Int. 51, 1463-1468.
24. Ries, C., Egea, V., Karow, M., Kolb, H., Jochum, M. & Neth, P. (2007) MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood 109, 4055-4063.
25. Semedo, P., Palasio, C.G., Oliveira, C.D., Feitoza, C.Q., Goncalves, G.M., Cenedeze, M.A., Wang, P.M., Teixeira, V.P., Reis, M.A., Pacheco-Silva, A. & Camara, N.O. (2009) Early modulation of inflammation by mesenchymal stem cell after acute kidney injury. Int. Immunopharmacol. 9, 677-682.
26. Semedo, P., Wang, P.M., Andreucci, T.H., Cenedeze, M.A., Teixeira, V.P., Reis, M.A., Pacheco-Silva, A. & Camara, N.O. (2007) Mesenchymal stem cells ameliorate tissue damages triggered by renal ischemia and reperfusion injury. Transplant. Proc. 39, 421-423.
27. Sheridan, A.M. & Bonventre, J.V. (2000) Cell biology and molecular mechanisms of injury in ischemic acute renal failure. Curr. Opin. Nephrol. Hypertens. 9, 427-434.
28. Simon, M., Maresh, J.G., Harris, S.E., Hernandez, J.D., Arar, M., Olson, M.S. & Abboud, H.E. (1999) Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney. Am. J. Physiol. 276, F382-F389.
29. Sordi, V., Malosio, M.L., Marchesi, F., Mercalli, A., Melzi, R., Giordano, T., Belmonte, N., Ferrari, G., Leone, B.E., Bertuzzi, F., Zerbini, G., Allavena, P., Bonifacio, E. & Piemonti, L. (2005) Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood 106, 419-427.
30. Tanaka, T., Nangaku, M., Miyata, T.Inaqi., R. Ohse, T., Ingelfinger, J.R. & Fujita, T. (2004) Blockade of calcium influx through L-type calcium channels attenuates. J. Am. Soc. Nephrol. 15, 2320-2333.
31. Togel, F., Hu, Z., Weiss, K., Isaac, J., Lange, C. & Westenfelder, C. (2005) Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation independent mechanism. Am. J. Physiol. Renal Physiol. 289, F31-F42.
32. Uccelli, A., Moretta, L. & Pistoia, V. (2006) Immunoregulatory function of mesenchymal stem cells. Eur. J. Immunol. 36, 2566-2573.
33. Vukicevic, S., Basic, V., Rogic, D., et al. (1998) Osteogenic protein-1(bone morphogenetic protein-7) reduced severity of injury after ischemic acute renal failure in rat. J. Clin. Invest. 102, 202-214.
34. Xu, Y.L., Gao, Y.H., Liu, Z., Tan, K.B., Hua, X., Fang, Z.Q., Wang, Y.L., Wang, Y.J., Xia, H.M. & Zhuo, Z.X. (2010) Myocardium-targeted transplantation of mesenchymal stem cells by diagnostic ultrasound-mediated microbubble destruction improves cardiac function in myocardial infarction of New Zealand rabbits. Int. J. Cardiol. 138, 182-195.
35. Yang, J., Zhou, W., Zheng, W., Ma, Y., Lin, L., Tang, T., Liu, J., Yu, J., Zhou, X. & Hu, J. (2007) Effects of myocardial transplantation of marrow mesenchymal stem cells transfected with vascular endothelial growth factor for the improvement of heart function and angiogenesis after myocardial infarction. Cardiology 107, 17-29.
36. Zeisberg, M., Shah, A.A. & Kalluri, R. (2005) Bone morphogenetic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J. Biol. Chem. 280, 8094-8100.