The increasing application of multiplex nucleic acid detection tests to the diagnosis of syndromic infections

Epidemiology and Infection

Volumn 142, Issue 1, 2014, Pages 1-11

  Gray, J ^a,b   Coupland, L J ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Clinical microbiology; Molecular biology; Virology; Virus infection

Indexed keywords

ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL INFECTION; COST BENEFIT ANALYSIS; GASTROENTERITIS; HUMAN; IN VITRO STUDY; INFECTION CONTROL; INTERMETHOD COMPARISON; LABORATORY TEST; MICROBIOLOGICAL EXAMINATION; MOLECULAR DIAGNOSIS; NONHUMAN; PARASITOSIS; PROCESS DEVELOPMENT; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT INFECTION; RISK REDUCTION; SENSITIVITY AND SPECIFICITY; UNITED STATES; VIRUS INFECTION;

EID: 84890102612     PISSN: 09502688     EISSN: 14694409     Source Type: Journal    
DOI: 10.1017/S0950268813002367     Document Type: Article

References (68)

1. Claas E, et al. Performance of the xTAG Gastrointestinal Pathogen Panel (GPP), a multiplex molecular assay for simultaneous detection of bacterial, viral and parasitic causes of infectious gastroenteritis. Journal of Microbiology and Biotechnology 2013; 23: 1041-1045
2. Coste JF, et al. Microbiological diagnosis of severe diarrhea in kidney transplant recipients by use of multiplex PCR assays. Journal of Clinical Microbiology 2013; 51: 1841-1849
3. Coupland LJ, et al. Simultaneous detection of viral and bacterial enteric pathogens using the Seeplex Diarrhea ACE detection system. Epidemiology and Infection. Published online: 5 December 2012. doi:10.1017/ S0950268812002622
4. Koziel M, et al. Improved detection of bacterial pathogens in patients presenting with gastroenteritis using the EntericBio Real-Time Gastro Panel I assay. Journal of Clinical Microbiology 2013; 51: 2679-2685
5. McAuliffe GN, et al. Systematic application of multiplex PCR enhances the detection of bacteria, parasites, and viruses in stool samples. Journal of Infection 2013; 67: 122-129
6. Stark D, et al. Evaluation of multiplex tandem real-time PCR for detection of Cryptosporidium spp., Dientamoeba fragilis, Entamoeba histolytica, and Giardia intestinalis in clinical stool samples. Journal of Clinical Microbiology 2011; 49: 257-262
7. Anderson TP, et al. Comparison of four multiplex PCR assays for the detection of viral pathogens in respiratory specimens. Journal of Virological Methods 2013; 191: 118-121
8. Dabisch-Ruthe M, et al. Comparison of three multiplex PCR assays for the detection of respiratory viral infections: Evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay. BMC Infectious Diseases 2012; 12: 163
9. Kim HK, et al. Comparison of Anyplex II RV16 with the xTAG respiratory viral panel and Seeplex RV15 for detection of respiratory viruses. Journal of Clinical Microbiology 2013; 51: 1137-1141
10. Pabbaraju K, et al. Comparison of the Luminex xTAG respiratory viral panel with in-house nucleic acid amplification tests for diagnosis of respiratory virus infections. Journal of Clinical Microbiology 2008; 46: 3056-3062
11. Pierce VM, Hodinka RL. Comparison of the GenMark Diagnostics eSensor respiratory viral panel to real-time PCR for detection of respiratory viruses in children. Journal of Clinical Microbiology 2012; 50: 3458-3465
12. Poritz MA, et al. FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: Development and application to respiratory tract infection. PLoS One 2011; 6: E26047
13. Sakthivel SK, et al. Comparison of fast-track diagnostics respiratory pathogens multiplex real-time RT-PCR assay with in-house singleplex assays for comprehensive detection of human respiratory viruses. Journal of Virological Methods 2012; 185: 259-266
14. Lee SJ, et al. Evaluation of Seeplex STD6 ACE Detection kit for the diagnosis of six bacterial sexually transmitted infections. Journal of Infection and Chemotherapy 2012; 18: 494-500
15. Shin SY, et al. Evaluation of the Seeplex Meningitis ACE Detection kit for the detection of 12 common bacterial and viral pathogens of acute meningitis. Annals of Laboratory Medicine 2012; 32: 44-49
16. Blaschke AJ, et al. Rapid identification of pathogens from positive blood cultures by multiplex polymerase chain reaction using the FilmArray system. Diagnostic Microbiology and Infectious Disease 2012; 74: 349-355
17. Josefson P, et al. Evaluation of a commercial multiplex PCR test (SeptiFast) in the etiological diagnosis of community-onset bloodstream infections. European Journal of Clinical Microbiology and Infectious Diseases 2011; 30: 1127-1134
18. Amar CF, et al. Detection by PCR of eight groups of enteric pathogens in 4,627 faecal samples: Re-examination of the English case-control Infectious Intestinal Disease Study (1993-1996). European Journal of Clinical Microbiology & Infectious Diseases 2007; 26: 311-323
19. Corless CE, et al. Development and evaluation of a 'real-time' RT-PCR for the detection of enterovirus and parechovirus RNA in CSF and throat swab samples. Journal of Medical Virology 2002; 67: 555-562
20. Stra;nska; R, et al. Routine use of a highly automated and internally controlled real-time PCR assay for the diagnosis of herpes simplex and varicella-zoster virus infections. Journal of Clinical Virology 2004; 30: 39-44
21. Templeton KE, et al. Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction. Clinical Infectious Diseases 2005; 41: 345-351
22. Templeton KE, et al. Rapid and sensitive method using multiplex real-time PCR for diagnosis of infections by influenza A and influenza B viruses, respiratory syncytial virus, and parainfluenza viruses 1, 2, 3, and 4. Journal of Clinical Microbiology 2004; 42: 1564-1569
23. Weinberg GA, et al. Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. Journal of Infectious Diseases 2004; 189: 706-710
24. Association for Molecular Pathology (AMP). FDAcleared/ approved molecular diagnostic tests (http:// www.amp.org/FDATable/). Accessed 22 February 2013
25. Leland DS, Ginocchio CC. Role of cell culture for virus detection in the age of technology. Clinical Microbiology Reviews 2007; 20: 49-78
26. Ogilvie M. Molecular techniques should not now replace cell culture in diagnostic virology laboratories. Reviews in Medical Virology 2001; 11: 351-354
27. Mackay IM. Real-time PCR in the microbiology laboratory. Clinical Microbiology and Infection 2004; 10: 190-212
28. Reddington K, et al. Advances in multiparametric molecular diagnostics technologies for respiratory tract infections. Current Opinion in Pulmonary Medicine 2013; 19: 298-304
29. Mengelle C, et al. Simultaneous detection of gastrointestinal pathogens with a multiplex Luminex-based molecular assay in stool samples from diarrhoeic patients. Clinical Microbiology and Infection. Published online: 29 April 2013. doi:10.1111/1469-0691.12255
30. Navidad JF, et al. Evaluation of Luminex xTAG® gastrointestinal pathogen analyte specific reagents for high-throughput, simultaneous detection of bacteria, viruses, and parasites of clinical and public health importance. Journal of Clinical Microbiology 2013; 51: 3018-3024
31. Niesters HG. Molecular and diagnostic clinical virology in real time. Clinical Microbiology and Infection 2004; 10: 5-11
32. Pierce VM, et al. Comparison of the Idaho Technology FilmArray system to real-time PCR for detection of respiratory pathogens in children. Journal of Clinical Microbiology 2012; 50: 364-3671
33. Oosterheert JJ, et al. Impact of rapid detection of viral and atypical bacterial pathogens by real-time polymerase chain reaction for patients with lower respiratory tract infection. Clinical Infectious Diseases 2005; 41: 1438-1444
34. van de Pol AC, et al. Diagnostic value of real-time polymerase chain reaction to detect viruses in young children admitted to the paediatric intensive care unit with lower respiratory tract infection. Critical Care 2006; 10: R61
35. Bissonnette L, Bergeron MG. Multiparametric technologies for the diagnosis of syndromic infections. Clinical Microbiology Newsletter 2012; 34: 159-168
36. Briese T, et al. Diagnostic system for rapid and sensitive differential detection of pathogens. Emerging Infectious Diseases 2005; 11: 310-313
37. Brunstein JD, et al. Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections. Journal of Clinical Microbiology 2008; 46: 97-102
38. Lueangarun S, Leelarasamee A. Impact of inappropriate empiric antimicrobial therapy on mortality of septic patients with bacteremia: A retrospective study. Interdisciplinary Perspectives on Infectious Diseases 2012; 2012: 765205
39. Malhotra-Kumar S, et al. Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: A randomised, double-blind, placebo-controlled study. Lancet 2007; 369: 482-490
40. Bouza E, et al. Bloodstream infections: A trial of the impact of different methods of reporting positive blood culture results. Journal of Infectious Diseases 2004; 39: 1161-1169
41. Chen HC, et al. Outcome of inadequate empirical antibiotic therapy in emergency department patients with community-onset bloodstream infections. Journal of Antimicrobial Chemotherapy 2012; 68: 947-953
42. Garnacho-Montero J, et al. Mortality and morbidity attributable to inadequate empirical antimicrobial therapy in patients admitted to the ICU with sepsis: A matched cohort study. Journal of Antimicrobial Chemotherapy 2008; 61: 436-441
43. Ibrahim EH, et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 2000; 118: 146-155
44. Retamar P, et al. Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: A propensity score-based analysis. Antimicrobial Agents and Chemotherapy 2012; 56: 472-478
45. Shehab N, et al. Emergency department visits for antibiotic-associated adverse events. Clinical Infectious Diseases 2008; 47: 735-743
46. Barenfanger J, Drake C, Kacich G. Clinical and financial benefits of rapid bacterial identification and antimicrobial susceptibility testing. Journal of Clinical Microbiology 1999; 37: 1415-1418
47. Barenfanger J, et al. Clinical and financial benefits of rapid detection of respiratory viruses: An outcomes study. Journal of Clinical Microbiology 2000; 38: 2824-2828
48. Byington CL, et al. The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital. Archives of Pediatrics and Adolescent Medicine 2002; 156: 1230-1234
49. Doern GV, et al. Clinical impact of rapid in vitro susceptibility testing and bacterial identification. Journal of Clinical Microbiology 1994; 32: 1757-1762
50. Galar A, et al. Clinical and economic evaluation of the impact of rapid microbiological diagnostic testing. Journal of Infection 2012; 65: 302-309
51. Henrickson KJ. Cost-effective use of rapid diagnostic techniques in the treatment and prevention of viral respiratory infections. Pediatric annals 2005; 34: 24-31
52. Woo PC, et al. Cost-effectiveness of rapid diagnosis of viral respiratory tract infections in pediatric patients. Journal of Clinical Microbiology 1997; 35: 1579-1581
53. Chen YS, et al. Comparison of diagnostic tools with multiplex polymerase chain reaction for pediatric lower respiratory tract infection: A single center study. Journal of Microbiology, Immunology and Infection. Published online 29 September 2012. doi:10.1016/j. jmii.2012.07.016
54. Tsalik EL, et al. Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. Journal of Clinical Microbiology 2010; 48: 26-33
55. Wishaupt JO, et al. Clinical impact of RT-PCR for pediatric acute respiratory infections: A controlled clinical trial. Pediatrics 2011; 128: E1113-1120
56. Brittain-Long R, et al. Access to a polymerase chain reaction assay method targeting 13 respiratory viruses can reduce antibiotics: A randomised, controlled trial. BMC Medicine 2011; 9: 44
57. Falsey AR, et al. Bacterial complications of respiratory tract viral illness: A comprehensive evaluation. Journal of Infectious Diseases 2013; 208: 432-441
58. Murdoch DR. Impact of rapid microbiological testing on the management of lower respiratory tract infection. Clinical Infectious Diseases 2005; 41: 1445-447
59. Dark PM, Dean P, Warhurst G. Bench-to-bedside review: The promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Critical Care 2009; 13: 217
60. Westh H, et al. Multiplex real-time PCR and blood culture for identification of bloodstream pathogens in patients with suspected sepsis. Clinical Microbiology and Infection 2009; 15: 544-551
61. Yanagihara K, et al. Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Critical Care 2010; 14: R159
62. Dark P, et al. The clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in intensive care using multipathogen real-time PCR technology. BMJ Open 2011; 1: E000181
63. Infectious Diseases Society of America. An unmet medical need: Rapid molecular diagnostics tests for respiratory tract infections. Clinical Infectious Diseases 2011; 52: S384-S395
64. Gerna G, et al. Correlation of rhinovirus load in the respiratory tract and clinical symptoms in hospitalized immunocompetent and immunocompromised patients. Journal of Medical Virology 2009; 81: 1498-1507
65. Phillips G, et al. Diagnosing norovirus-associated infectious intestinal disease using viral load. BMC Infectious Diseases 2009; 9: 63
66. Schuetz P, Raad I, Amin DN. Using procalcitoninguided algorithms to improve antimicrobial therapy in ICU patients with respiratory infections and sepsis. Current Opinion in Critical Care. Published online 11 July 2013. doi:10.1097/MCC. 0b013e328363bd38
67. Dundas NE, et al. A lean laboratory: Operational simplicity and cost effectiveness of the Luminex xTAG™ respiratory viral panel. Journal of Molecular Diagnostics 2011; 13: 175-179
68. Mahony JB, et al. Cost analysis of multiplex PCR testing for diagnosing respiratory virus infections. Journal of Clinical Microbiology 2009; 47: 2812- 2817