Insulin resistance increases MRI-estimated pancreatic fat in nonalcoholic fatty liver disease and normal controls

Gastroenterology Research and Practice

Volumn 2013, Issue , 2013, Pages

  Patel, Niraj S ^a   Peterson, Michael R ^b   Lin, Grace Y ^b   Feldstein, Ariel ^c   Schnabl, Bernd ^a   Bettencourt, Ricki ^b   Seki, Ekihiro ^a   Sirlin, Claude B ^b   Loomba, Rohit ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PROTON;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; FAT CONTENT; FATTY LIVER; FEMALE; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; LIPIDOSIS; LIVER BIOPSY; MALE; METABOLIC SYNDROME X; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS LIPIDOSIS; PROSPECTIVE STUDY;

EID: 84890101967     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2013/498296     Document Type: Article

References (44)

1. Clark J. M., The epidemiology of nonalcoholic fatty liver disease in adults. Journal of Clinical Gastroenterology 2006 40 supplement 1 S5 S10 2-s2.0-33747517955 10.1097/01.mcg.0000168638.84840.ff (Pubitemid 44309537)
2. Kotronen A., Peltonen M., Hakkarainen A., Sevastianova K., Bergholm R., Johansson L. M., Lundbom N., Rissanen A., Ridderstråle M., Groop L., Orho-Melander M., Yki-Järvinen H., Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 2009 137 3 865 872 2-s2.0-69249087403 10.1053/j.gastro.2009.06.005
3. Marchesini G., Bugianesi E., Forlani G., Cerrelli F., Lenzi M., Manini R., Natale S., Vanni E., Villanova N., Melchionda N., Rizzetto M., Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003 37 4 917 923 2-s2.0-0037382786 10.1053/jhep.2003.50161 (Pubitemid 36397405)
4. Vernon G., Baranova A., Younossi Z. M., Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Alimentary Pharmacology and Therapeutics 2011 34 3 274 285 2-s2.0-79960029926 10.1111/j.1365-2036.2011. 04724.x
5. Browning J. D., Szczepaniak L. S., Dobbins R., Nuremberg P., Horton J. D., Cohen J. C., Grundy S. M., Hobbs H. H., Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology 2004 40 6 1387 1395 2-s2.0-10644220306 10.1002/hep.20466 (Pubitemid 39657013)
6. Williams C. D., Stengel J., Asike M. I., Torres D. M., Shaw J., Contreras M., Landt C. L., Harrison S. A., Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology 2011 140 1 124 131 2-s2.0-78650486196 10.1053/j.gastro.2010.09.038
7. Bellentani S., Scaglioni F., Marino M., Bedogni G., Epidemiology of non-alcoholic fatty liver disease. Digestive Diseases 2010 28 1 155 161 2-s2.0-77952576769 10.1159/000282080
8. Bhala N., Angulo P., van der Poorten D., Lee E., Hui J. M., Saracco G., Adams L. A., Charatcharoenwitthaya P., Topping J. H., Bugianesi E., Day C. P., George J., The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 2011 54 4 1208 1216 2-s2.0-79960549297 10.1002/hep.24491
9. Pitt H. A., Hepato-pancreato-biliary fat: the good, the bad and the ugly. HPB 2007 9 2 92 97 2-s2.0-34247637185 10.1080/13651820701286177 (Pubitemid 46672381)
10. Wu W. C., Wang C. Y., Association between non-alcoholic fatty pancreatic disease (nafpd) and the metabolic syndrome: case-control retrospective study. Cardiovasc Diabetol 2013 12, article 77 10.1186/1475-2840-12-77
11. Al-Haddad M., Khashab M., Zyromski N., Pungpapong S., Wallace M. B., Scolapio J., Woodward T., Noh K., Raimondo M., Risk factors for hyperechogenic pancreas on endoscopic ultrasound: a case-control study. Pancreas 2009 38 6 672 675 2-s2.0-68949132763 10.1097/MPA.0b013e3181a9d5af
12. Lee J. S., Kim S. H., Jun D. W., Han J. H., Jang E. C., Park J. Y., Son B. K., Kim S. H., Jo Y. J., Park Y. S., Kim Y. S., Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World Journal of Gastroenterology 2009 15 15 1869 1875 2-s2.0-67651241512 10.3748/wjg.15.1869
13. Sepe P. S., Ohri A., Sanaka S., Berzin T. M., Sekhon S., Bennett G., Mehta G., Chuttani R., Kane R., Pleskow D., Sawhney M. S., A prospective evaluation of fatty pancreas by using EUS. Gastrointestinal Endoscopy 2011 73 5 987 993 2-s2.0-79955423315 10.1016/j.gie.2011.01.015
14. Sijens P. E., Edens M. A., Bakker S. J. L., Stolk R. P., MRI-determined fat content of human liver, pancreas and kidney. World Journal of Gastroenterology 2010 16 16 1993 1998 2-s2.0-77951949746 10.3748/wjg.v16.i16. 1993
15. Choi C. W., Kim G. H., Kang D. H., Kim H. W., Kim D. U., Heo J., Song G. A., Park D. Y., Kim S., Associated factors for a hyperechogenic pancreas on endoscopic ultrasound. World Journal of Gastroenterology 2010 16 34 4329 4334 2-s2.0-77957562072 10.3748/wjg.v16.i34.4329
16. Patel N. S., Peterson M. R., Brenner D. A., Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Alimentary Pharmacology & Therapeutics 2013 37 6 630 639 10.1111/apt.12237
17. 1 independent, T 2 corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. Journal of Magnetic Resonance Imaging 2011 33 4 873 881 2-s2.0-79953246982 10.1002/jmri.22514
18. Kleiner D. E., Brunt E. M., van Natta M., Behling C., Contos M. J., Cummings O. W., Ferrell L. D., Liu Y.-C., Torbenson M. S., Unalp-Arida A., Yeh M., McCullough A. J., Sanyal A. J., Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005 41 6 1313 1321 2-s2.0-20044374023 10.1002/hep.20701 (Pubitemid 40770284)
19. Szczepaniak L. S., Nurenberg P., Leonard D., Browning J. D., Reingold J. S., Grundy S., Hobbs H. H., Dobbins R. L., Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. American Journal of Physiology: Endocrinology and Metabolism 2005 288 2 E462 E468 2-s2.0-12144259379 10.1152/ajpendo.00064.2004 (Pubitemid 40110657)
20. Permutt Z., Le T.-A., Peterson M. R., Seki E., Brenner D. A., Sirlin C., Loomba R., Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease-MRI accurately quantifies hepatic steatosis in NAFLD. Alimentary Pharmacology and Therapeutics 2012 36 22 29 2-s2.0-84860507097 10.1111/j.1365-2036.2012.05121.x
21. Noureddin M., Lam J., Peterson M. R., Longitudinal comparison between MRI, MRS and histology-determined steatosis in NAFLD patients at two-time points in a randomized trial. Hepatology 2013 10.1002/hep.26455
22. Yokoo T., Bydder M., Hamilton G., Middleton M. S., Gamst A. C., Wolfson T., Hassanein T., Patton H. M., Lavine J. E., Schwimmer J. B., Sirlin C. B., Nonalcoholic fatty liver disease: Diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology 2009 251 1 67 76 2-s2.0-64949095273 10.1148/radiol.2511080666
23. Yokoo T., Shiehmorteza M., Hamilton G., Wolfson T., Schroeder M. E., Middleton M. S., Bydder M., Gamst A. C., Kono Y., Kuo A., Patton H. M., Horgan S., Lavine J. E., Schwimmer J. B., Sirlin C. B., Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. Radiology 2011 258 3 749 759 2-s2.0-79952309399 10.1148/radiol.10100659
24. Le T. A., Chen J., Changchien C., Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology 2012 56 3 922 932 10.1002/hep.25731
25. Schwenzer N. F., Machann J., Martirosian P., Stefan N., Schraml C., Fritsche A., Claussen C. D., Schick F., Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques. Investigative Radiology 2008 43 5 330 337 2-s2.0-42449104466 10.1097/RLI.0b013e31816a88c6 (Pubitemid 351572210)
26. Kang G. H., Cruite I., Shiehmorteza M., Wolfson T., Gamst A. C., Hamilton G., Bydder M., Middleton M. S., Sirlin C. B., Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. Journal of Magnetic Resonance Imaging 2011 34 4 928 934 2-s2.0-80053011699 10.1002/jmri.22701
27. Loomba R., Hwang S.-J., O'Donnell C. J., Ellison R. C., Vasan R. S., D'Agostino R. B. Sr., Liang T. J., Fox C. S., Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham Heart study. Gastroenterology 2008 134 4 953.e1 959.e1 2-s2.0-41349119137 10.1053/j.gastro.2008.01.037 (Pubitemid 351451983)
28. Loomba R., Rao F., Zhang L., Khandrika S., Ziegler M. G., Brenner D. A., O'Connor D. T., Genetic covariance between γ -glutamyl transpeptidase and fatty liver risk factors: role of β 2-adrenergic receptor genetic variation in twins. Gastroenterology 2010 139 3 836.e1 845.e1 2-s2.0-77956136763 10.1053/j.gastro.2010.06.009
29. Olsen T. S., Inst. pathol. Glostrup Hosp. Copenhagen I. P. G. H. C., Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathologica et Microbiologica Scandinavica A 1978 86 5 367 373 2-s2.0-0018119115 (Pubitemid 9031936)
30. Stamm B. H., Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Human Pathology 1984 15 7 677 683 2-s2.0-0021697386 (Pubitemid 15161459)
31. van Geenen E.-J. M., Smits M. M., Schreuder T. C. M. A., van der Peet D. L., Bloemena E., Mulder C. J. J., Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas 2010 39 8 1185 1190 2-s2.0-77958576631 10.1097/MPA.0b013e3181f6fce2
32. Ou H. Y., Wang C. Y., Yang Y. C., The association between nonalcoholic fatty pancreas disease and diabetes. PLoS One 2013 8 e62561 10.1371/journal. pone.0062561
33. Li J., Xie Y., Yuan F., Song B., Tang C., Noninvasive quantification of pancreatic fat in healthy male population using chemical shift magnetic resonance imaging: effect of aging on pancreatic fat content. Pancreas 2011 40 2 295 299 2-s2.0-79951724165 10.1097/MPA.0b013e318201669f
34. Targher G., Rossi A. P., Zamboni G. A., Pancreatic fat accumulation and its relationship with liver fat content and other fat depots in obese individuals. Journal of Endocrinological Investigation 2012 35 748 753
35. Dixon J. B., Bhathal P. S., O'Brien P. E., Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001 121 1 91 100 2-s2.0-0034950652 (Pubitemid 32591518)
36. Salgado A. L. F. D. A., de Carvalho L., Oliveira A. C., dos Santos V. N., Vieira J. G., Parise E. R., Insulin resistance index (HOMA-IR) in the differentiation of patients with non-alcoholic fatty liver disease and healthy individuals. Arquivos de Gastroenterologia 2010 47 2 165 169 2-s2.0-77957295687 10.1590/S0004-28032010000200009
37. Neuschwander-Tetri B. A., Clark J. M., Bass N. M., van Natta M. L., Unalp-Arida A., Tonascia J., Zein C. O., Brunt E. M., Kleiner D. E., McCullough A. J., Sanyal A. J., Diehl A. M., Lavine J. E., Chalasani N., Kowdley K. V., Clinical, laboratory and histological associations in adults with nonalcoholic fatty liver disease. Hepatology 2010 52 3 913 924 2-s2.0-77956639983 10.1002/hep.23784
38. Loomba R., Abraham M., Unalp A., Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology 2012 56 3 943 951 10.1002/hep.25772
39. Pais R., Charlotte F., Fedchuk L., A systematic review of follow-up biopsies reveals disease progression in patients with non-alcoholic fatty liver. Journal of Hepatology 2013 59 3 550 556 10.1016/j.jhep.2013.04.027
40. Doycheva I., Patel N., Peterson M., Loomba R., Prognostic implication of liver histology in patients with nonalcoholic fatty liver disease in diabetes. Journal of Diabetes and Its Complications 2013 27 3 293 300 10.1016/j.jdiacomp. 2012.10.008
41. Heni M., Machann J., Staiger H., Schwenzer N. F., Peter A., Schick F., Claussen C. D., Stefan N., Häring H.-U., Fritsche A., Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes/Metabolism Research and Reviews 2010 26 3 200 205 2-s2.0-77952396750 10.1002/dmrr.1073
42. Tushuizen M. E., Bunck M. C., Pouwels P. F., Bontemps S., van Waesberghe J. H., Schindhelm R. K., Mari A., Heine R. J., Diamant M., Pancreatic fat content and beta;-cell function in men with and without type 2 diabetes. Diabetes Care 2007 30 2916 2921 (Pubitemid 350083144)
43. Musso G., Cassader M., De Michieli F., Rosina F., Orlandi F., Gambino R., Nonalcoholic steatohepatitis versus steatosis: adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology 2012 56 3 933 942 10.1002/hep.25739
44. Maggio A. B. R., Mueller P., Wacker J., Viallon M., Belli D. C., Beghetti M., Farpour-Lambert N. J., McLin V. A., Increased pancreatic fat fraction is present in obese adolescents with metabolic syndrome. Journal of Pediatric Gastroenterology and Nutrition 2012 54 720 726 2-s2.0-82755197314 10.1097/MPG.0b013e318244a685