T1 independent, T2* corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis

Journal of Magnetic Resonance Imaging

Volumn 33, Issue 4, 2011, Pages 873-881

  Hines, Catherine D G ^a   Frydrychowicz, Alex ^a,b   Hamilton, Gavin ^c   Tudorascu, Dana L ^d   Vigen, Karl K ^a   Yu, Huanzhou ^e   McKenzie, Charles A ^f   Sirlin, Claude B ^c   Brittain, Jean H ^e   Reeder, Scott B ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e GE HEALTHCARE   (United States)

^f UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Fat quantification; Hepatic steatosis; MR spectroscopy; MRI; Nonalcoholic fatty liver disease

Indexed keywords

ACCURACY; ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONFIDENCE INTERVAL; DIAGNOSTIC TEST ACCURACY STUDY; FAT CONTENT; FATTY LIVER; FEMALE; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SENSITIVITY AND SPECIFICITY;

ADIPOSE TISSUE; ADULT; AGED; AGED, 80 AND OVER; BODY WATER; FATTY LIVER; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 79953246982     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.22514     Document Type: Article

References (41)

1. Sass DA Chang P, Chopra KB. Nonalcoholic fatty liver disease: a clinical review. Dig Dis Sci 2005;50:171-180. (Pubitemid 40379159)
2. Harrison SA, Neuschwander-Tetri BA. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Clin Liver Dis 2004;8:861-879, ix.
3. Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-1850. (Pubitemid 33641605)
4. Marchesini G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999;107:450-455. (Pubitemid 29528333)
5. Brunt EM. Nonalcoholic steatohepatitis. Semin Liver Dis 2004;24:3-20. (Pubitemid 38496045)
6. McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004;8:521-533, viii.
7. Cuadrado A, Orive A, Garcia-Suarez C, et al. Non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma. Obesi Surg 2005;15:422-426.
8. Smedile A, Bugianesi E. Steatosis and hepatocellular carcinoma risk. Eur Rev Med Pharmacol Sci 2005;9:291-293. (Pubitemid 41387394)
9. Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005;128:1898-1906. (Pubitemid 40824701)
10. Thomsen C, Becker U, Winkler K, Christoffersen P, Jensen M, Henriksen O. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 1994;12:487-495. (Pubitemid 24113193)
11. Wong WF, Northrup SR, Herrick RC, Glombicki AP, Wood RP, Morrisett JD. Quantitation of lipid in biological tissue by chemical shift magnetic resonance imaging. Magn Reson Med 1994;32:440-446. (Pubitemid 24307970)
12. Bohte AE, van Werven JR, Bipat S, Stoker J. The diagnostic accuracy of US, CT, MRI and (1)H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. Eur Radiol 2011;21:87-97.
13. Bydder M, Yokoo T, Hamilton G, et al. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging 2008;26:347-359.
14. Reeder SB, Robson PM, Yu H, et al. Quantification of hepatic steatosis with MRI: the effects of accurate fat spectral modeling. J Magn Reson Imaging 2009;29:1332-1339.
15. Yokoo T, Bydder M, Hamilton G, et al. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology 2009;251:67-76.
16. Hu HH, Kim HW, Nayak KS, Goran MI. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 2009;18:841-847.
17. Hines CD, Yu H, Shimakawa A, et al. Quantification of hepatic steatosis with 3-T MR imaging: validation in ob/ob mice. Radiology 2010;254:119-128.
18. Sirlin CB, Reeder SB. Magnetic resonance imaging quantification of liver iron. Magn Reson Imaging Clin N Am 2010;18:359-381, ix.
19. Liu CY, McKenzie CA, Yu H, Brittain JH, Reeder SB. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 2007;58:354-364. (Pubitemid 47267653)
20. Fishbein MH, Gardner KG, Potter CJ, Schmalbrock P, Smith MA. Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 1997;15:287-293. (Pubitemid 27280484)
21. Hussain HK, Chenevert TL, Londy FJ, et al. Hepatic fat fraction: MR imaging for quantitative measurement and display - early experience. Radiology 2005;237:1048-1055. (Pubitemid 41636400)
22. Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB. Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008;60:1122-1134.
23. Yu H, McKenzie CA, Shimakawa A, et al. Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation. J Magn Reson Imaging 2007;26:1153-1161. (Pubitemid 47548182)
24. Yu H, Shimakawa A, Reeder SB, McKenzie CA, Brittain JH. Magnitude fitting following phase sensitive water-fat separation to remove effects of phase errors. In: Proceedings of the 17th Annual Meeting of ISMRM, Honolulu, 2009. (abstract 462).
25. Meisamy S, Hines CD, Hamilton G, et al. Quantification of hepatic steatosis using T1 independent, T2* corrected MRI with accurate spectral modeling: a blinded comparison with 1H MR spectroscopoy. Radiology [Epub ahead of print].
26. Hines CD, Yu H, Shimakawa A, et al. T1 independent, T2* corrected MRI with accurate spectral modeling for quantification of fat: validation in a fat-water-SPIO phantom. J Magn Reson Imaging 2009;30:1215-1222.
27. Reeder SB, McKenzie CA, Pineda AR, et al. Water-fat separation with IDEAL gradient-echo imaging. J Magn Reson Imaging 2007;25:644-652. (Pubitemid 46355429)
28. Beatty PJ, Brau AC, Chang P, et al. A method for autocalibrating 2-D accelerated volumetric parallel imaging with clinically practical reconstruction times. In: Proceedings of the 15th Annual Meeting of ISMRM, Berlin, 2007. (abstract 1749).
29. Brau AC, Beatty PJ, Skare S, Bammer R. Comparison of reconstruction accuracy and efficiency among autocalibrating data-driven parallel imaging methods. Magn Reson Med 2008;59:382-395. (Pubitemid 351220102)
30. Hamilton G, Middleton MS, Bydder M, et al. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging 2009;30:145-152.
31. Hines CD, Yokoo T, Bydder M, Sirlin CB, Reeder SB. Optimization of flip angle to allow tradeoffs in T1 bias and SNR performance for fat quantification. In: Proceedings of the 18th Annual Meeting of ISMRM, Stockholm, 2010. (abstract 2927).
32. de Bazelaire CM, Duhamel GD, Rofsky NM, Alsop DC. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 2004;230:652-659. (Pubitemid 38252858)
33. Bydder M, Hamilton G, Yokoo T, Sirlin CB. Optimal phased-array combination for spectroscopy. Magn Reson Imaging 2008;26:847-850.
34. Hamilton G, Yokoo T, Bydder M, et al. In vivo characterization of the liver fat 1H magentic resonance spectrum. NMR Biomed 2010 (in press).
35. Sharma P, Martin DR, Pineda N, et al. Quantitative analysis of T2-correction in single-voxel magnetic resonance spectroscopy of hepatic lipid fraction. J Magn Reson Imaging 2009;29:629-635.
36. Lin L, Torbeck LD. Coefficient of accuracy and concordance correlation coefficient: new statistics for methods comparison. PDA J Pharm Sci Technol 1998;52:55-59. (Pubitemid 28225979)
37. Szczepaniak LS, Nurenberg P, Leonard D, et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 2005;288:E462-E468. (Pubitemid 40110657)
38. R Development Core Team R. A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2009.
39. Hamer OW, Aguirre DA, Casola G, Lavine JE, Woenckhaus M, Sirlin CB. Fatty liver: imaging patterns and pitfalls. Radiographics 2006;26:1637-1653.
40. van Werven JR, Hoogduin JM, Nederveen AJ, et al. Reproducibility of 3.0 Tesla magnetic resonance spectroscopy for measuring hepatic fat content. J Magn Reson Imaging 2009;30:444-448.
41. Schwenzer NF, Machann J, Haap MM, et al. T2* relaxometry in liver, pancreas, and spleen in a healthy cohort of one hundred twenty-ine subjects-correlation with age, gender, and serum ferritin. Invest Radiol 2008;43:854-860.