Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease

Alimentary Pharmacology and Therapeutics

Volumn 37, Issue 6, 2013, Pages 630-639

  Patel, N S ^a   Peterson, M R ^b   Brenner, D A ^a   Heba, E ^c   Sirlin, C ^c   Loomba, R ^a,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FAT CONTENT; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIPID STORAGE; LIVER BIOPSY; LIVER FIBROSIS; MALE; NONALCOHOLIC FATTY LIVER; NONALCOHOLIC FATTY LIVER DISEASE ACTIVITY SCORE; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREATIC FAT; PANCREATIC STEATOSIS; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTON DENSITY FAT FRACTION; QUANTITATIVE ANALYSIS; STEATOSIS;

ADIPOSITY; ADULT; BIOPSY; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FATTY LIVER; FEMALE; HUMANS; LIVER CIRRHOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PANCREAS; PREDICTIVE VALUE OF TESTS; SEVERITY OF ILLNESS INDEX;

EID: 84874115167     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12237     Document Type: Article

References (53)

1. Bellentani S, Scaglioni F, Marino M, et al,. Epidemiology of non-alcoholic fatty liver disease. Dig Dis 2010; 28: 155-61.
2. Vernon G, Baranova A, Younossi ZM,. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34: 274-85.
3. Clark JM,. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol 2006; 40 (Suppl. 1): S5-10.
4. Kotronen A, Peltonen M, Hakkarainen A, et al,. Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors. Gastroenterology 2009; 137: 865-72.
5. van Raalte DH, van der Zijl NJ, Diamant M,. Pancreatic steatosis in humans: cause or marker of lipotoxicity? Curr Opin Clin Nutr Metab Care 2010; 13: 478-85.
6. Brunt EM, Janney CG, Di Bisceglie AM, et al,. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467-74.
7. Diehl AM, Li ZP, Lin HZ, et al,. Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 2005; 54: 303-6.
8. Farrell GC, Larter CZ,. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006; 43: S99-112.
9. Baffy G, Brunt EM, Caldwell SH,. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 2012; 56: 1384-91.
10. Torres DM, Williams CD, Harrison SA,. Features, diagnosis, and treatment of nonalcoholic Fatty liver disease. Clin Gastroenterol Hepatol 2012; 10: 837-58.
11. Pitt HA,. Hepato-pancreato-biliary fat: the good, the bad and the ugly. HPB (Oxford) 2007; 9: 92-7.
12. Tushuizen ME, Bunck MC, Pouwels PJ, et al,. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007; 30: 2916-21.
13. Heni M, Machann J, Staiger H, et al,. Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev 2010; 26: 200-5.
14. Lozano M, Navarro S, Perez-Ayuso R, et al,. Lipomatosis of the pancreas: an unusual cause of massive steatorrhea. Pancreas 1988; 3: 580-2.
15. Mathur A, Pitt HA, Marine M, et al,. Fatty pancreas: a factor in postoperative pancreatic fistula. Ann Surg 2007; 246: 1058-64.
16. Mathur A, Zyromski NJ, Pitt HA, et al,. Pancreatic steatosis promotes dissemination and lethality of pancreatic cancer. J Am Coll Surg 2009; 208: 989-94.
17. Navina S, Acharya C, DeLany JP, et al,. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med 2011; 3: 107-10.
18. Olsen TS,. Lipomatosis of the pancreas in autopsy material and its relation to age and overweight. Acta Pathol Microbiol Scand A 1978; 86A: 367-73.
19. Stamm BH,. Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease. Hum Pathol 1984; 15: 677-83.
20. Saisho Y, Butler AE, Meier JJ, et al,. Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes. Clin Anat 2007; 20: 933-42.
21. Lee JS, Kim SH, Jun DW, et al,. Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome. World J Gastroenterol 2009; 15: 1869-75.
22. Sijens PE, Edens MA, Bakker SJ, et al,. MRI-determined fat content of human liver, pancreas and kidney. World J Gastroenterol 2010; 16: 1993-8.
23. Li J, Xie Y, Yuan F, et al,. Noninvasive quantification of pancreatic fat in healthy male population using chemical shift magnetic resonance imaging: effect of aging on pancreatic fat content. Pancreas 2011; 40: 295-9.
24. Sepe PS, Ohri A, Sanaka S, et al,. A prospective evaluation of fatty pancreas by using EUS. Gastrointest Endosc 2011; 73: 987-93.
25. Bydder M, Yokoo T, Hamilton G, et al,. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging 2008; 26: 347-59.
26. Liu CY, McKenzie CA, Yu H, et al,. Fat quantification with IDEAL gradient echo imaging: correction of bias from T(1) and noise. Magn Reson Med 2007; 58: 354-64.
27. Yu H, McKenzie CA, Shimakawa A, et al,. Multiecho reconstruction for simultaneous water-fat decomposition and T2* estimation. J Magn Reson Imaging 2007; 26: 1153-61.
28. Hines CD, Frydrychowicz A, Hamilton G, et al,. T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. J Magn Reson Imaging 2011; 33: 873-81.
29. Yu H, Shimakawa A, McKenzie CA, et al,. Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 2008; 60: 1122-34.
30. Kleiner DE, Brunt EM, Van Natta M, et al,. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-21.
31. Yu H, Shimakawa A, Hines CD, et al,. Combination of complex-based and magnitude-based multiecho water-fat separation for accurate quantification of fat-fraction. Magn Reson Med 2011; 66: 199-206.
32. Hernando D, Hines CD, Yu H, et al,. Addressing phase errors in fat-water imaging using a mixed magnitude/complex fitting method. Magn Reson Med 2012; 67: 638-44.
33. Reeder SB, Cruite I, Hamilton G, Sirlin CB,. Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging 2011; 34: 729-49.
34. Kang GH, Cruite I, Shiehmorteza M, et al,. Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. J Magn Reson Imaging 2011; 34: 928-34.
35. Schwenzer NF, Machann J, Martirosian P, et al,. Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques. Invest Radiol 2008; 43: 330-7.
36. Le TA, Chen J, Changchien C, et al,. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology 2012; 56: 922-32.
37. Permutt Z, Le TA, Peterson MR, et al,. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease-MRI accurately quantifies hepatic steatosis in NAFLD. Aliment Pharmacol Ther 2012; 36: 22-9.
38. Rossi AP, Fantin F, Zamboni GA, et al,. Predictors of ectopic fat accumulation in liver and pancreas in obese men and women. Obesity (Silver Spring) 2011; 19: 1747-54.
39. Hannukainen JC, Borra R, Linderborg K, et al,. Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity. J Hepatol 2011; 54: 545-52.
40. van Geenen EJ, Smits MM, Schreuder TC, et al,. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas 2010; 39: 1185-90.
41. Orci L, Stefan Y, Malaisse-Lagae F, et al,. Pancreatic fat. N Engl J Med 1979; 301: 1292.
42. Marchal G, Verbeken E, Van Steenbergen W, et al,. Uneven lipomatosis: a pitfall in pancreatic sonography. Gastrointest Radiol 1989; 14: 233-7.
43. Glaser J, Stienecker K,. Pancreas and aging: a study using ultrasonography. Gerontology 2000; 46: 93-6.
44. Meisamy S, Hines CD, Hamilton G, et al,. Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modeling of fat: blinded comparison with MR spectroscopy. Radiology 2011; 258: 767-75.
45. Matsumoto S, Mori H, Miyake H, et al,. Uneven fatty replacement of the pancreas: evaluation with CT. Radiology 1995; 194: 453-8.
46. Isserow JA, Siegelman ES, Mammone J,. Focal fatty infiltration of the pancreas: MR characterization with chemical shift imaging. AJR Am J Roentgenol 1999; 173: 1263-5.
47. Kim HJ, Byun JH, Park SH, et al,. Focal fatty replacement of the pancreas: usefulness of chemical shift MRI. AJR Am J Roentgenol 2007; 188: 429-32.
48. Kawamoto S, Siegelman SS, Bluemke DA, et al,. Focal fatty infiltration in the head of the pancreas: evaluation with multidetector computed tomography with multiplanar reformation imaging. J Comput Assist Tomogr 2009; 33: 90-5.
49. Pitchumoni CS, Glasser M, Saran RM, et al,. Pancreatic fibrosis in chronic alcoholics and nonalcoholics without clinical pancreatitis. Am J Gastroenterol 1984; 79: 382-8.
50. Mathur A, Marine M, Lu D, et al,. Nonalcoholic fatty pancreas disease. HPB (Oxford) 2007; 9: 312-8.
51. Zhang X, Cui Y, Fang L, et al,. Chronic high-fat diets induce oxide injuries and fibrogenesis of pancreatic cells in rats. Pancreas 2008; 37: e31-8.
52. Hamilton G, Yokoo T, Bydder M, et al,. In vivo characterization of the liver fat (1)H MR spectrum. NMR Biomed 2011; 24: 784-90.
53. Fischer MA, Nanz D, Reiner CS, et al,. Diagnostic performance and accuracy of 3-D spoiled gradient-dual-echo MRI with water- and fat-signal separation in liver-fat quantification: comparison to liver biopsy. Invest Radiol 2010; 45: 465-70.