Pancreatic fat accumulation and its relationship with liver fat content and other fat depots in obese individuals

Journal of Endocrinological Investigation

Volumn 35, Issue 8, 2012, Pages 748-753

  Targher, G ^a   Rossi, A P ^a   Zamboni, G A ^b   Fantin, F ^a   Antonioli, A ^a   Corzato, F ^a   Bambace, C ^a   Pozzi Mucelli, R ^b   Zamboni, M ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

Liver fat content; Non alcoholic fatty liver disease; Obesity; Pancreatic fat content; Visceral fat content

Indexed keywords

ADIPONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL FEATURE; CORRELATIONAL STUDY; FAT CONTENT; FATTY LIVER; HUMAN; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LIPID STORAGE; METABOLIC SYNDROME X; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PANCREATIC FAT ACCUMULATION; TRIACYLGLYCEROL BLOOD LEVEL;

ABDOMINAL FAT; ADIPOSITY; ADULT; BODY MASS INDEX; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBESITY; PANCREAS; PROGNOSIS;

EID: 84869232426     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/8011     Document Type: Article

References (26)

1. Ogden CL, Yanovski SZ, Carroll MD, Flegal KM. The epidemiology of obesity. Gastroenterology 2007, 132: 2087-102. (Pubitemid 46693751)
2. Weinberg JM. Lipotoxicity. Kidney Int 2006, 10: 1560-6. (Pubitemid 44606990)
3. de Alwis NMW, Day CP. Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol 2008, 48 (Suppl 1): S104-12.
4. Kotronen A, Yki-Järvinen H. Fatty liver: a novel component of the metabolic syndrome. Arterioscler Thromb Vasc Biol 2008, 28: 27-38.
5. Tushuizen ME, Bunck MC, Pouwels PJ, et al. Pancreatic fat content and beta-cell function in men with and without type 2 diabetes. Diabetes Care 2007, 30: 2916-21. (Pubitemid 350083144)
6. Lingvay I, Esser V, Legendre JL, et al. Noninvasive quantification of pancreatic fat in humans. J Clin Endocrinol Metab 2009, 94: 4070-6.
7. van der Zijl NJ, Goossens GH, Moors CC, et al. Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab 2011, 96: 459-67.
8. Sijens PE, Edens MA, Bakker SJ, Stolk RP. MRI-determined fat content of human liver, pancreas and kidney. World J Gastroenterol 2010, 16: 1993-8.
9. Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging. Pediatr Radiol 2005, 35: 601-7. (Pubitemid 40724032)
10. Hannukainen JC, Borra R, Linderborg K, et al. Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity. J Hepatol 2011, 54: 545-52.
11. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000, 23: 57-63. (Pubitemid 30022895)
12. Ross R, Léger L, Morris D, de Guise J, Guardo R. Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 1992, 72: 787-95.
13. Johnson D, Dixon A, Abrahams P. The abdominal subcutaneous tissue: computed tomographic, magnetic resonance, and anatomical observations. Clin Anat 1996, 9: 19-24. (Pubitemid 26011194)
14. Schwenzer NF, Machann J, Martirosian P, et al. Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectral-spatial excitation techniques. Invest Radiol 2008, 43: 3330-7.
15. Bahl M, Qayyum A, Westphalen AC, et al. Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurements as biomarkers. Radiology 2008, 249: 160-6.
16. Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 2009, 51: 433-45.
17. Lee SE, Jang JY, Lim CS, et al. Measurement of pancreatic fat by magnetic resonance imaging. Predicting the occurrence of pancreatic fistula after pancreatoduodenectomy. Ann Surg 2010, 251: 932-6.
18. Hu HH, Kim HE, Nayak KS, Goran MI. Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 2010, 18: 841-7.
19. Stefan N, Kantartzis K, Häring HU. Causes and metabolic consequences of fatty liver. Endocr Rev 2008, 29: 939-60.
20. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010, 363: 1341-50.
21. van Geenen EJ, Smits MM, Schreuder TC, van der Peet DL, Bloemena E, Mulder CJ. Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease. Pancreas 2010, 39: 1185-90.
22. Lê KA, Ventura EE, Fisher JQ, et al. Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care 2011, 34: 485-90.
23. Heni M, Machann J, Staiger H, et al. Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev 2010, 26: 200-5.
24. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007, 132: 2169-80. (Pubitemid 46693756)
25. Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 2001, 50 (Suppl 1): S118-21. (Pubitemid 32148232)
26. Pitt HA. Hepato-pancreato-biliary fat: the good, the bad and the ugly. HPB (Oxford) 2007, 9: 92-7. (Pubitemid 46672381)