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Volumn 123, Issue 12, 2013, Pages 5001-5004

Tuning mTOR activity for immune balance

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; MAMMALIAN TARGET OF RAPAMYCIN; TRANSCRIPTION FACTOR FKHRL1; TRANSFORMING GROWTH FACTOR BETA;

EID: 84890093365     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI73202     Document Type: Review
Times cited : (8)

References (24)
  • 1
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012;149(2):274-293
    • (2012) Cell , vol.149 , Issue.2 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 2
    • 84860237060 scopus 로고    scopus 로고
    • Regulation and function of mTOR signalling in T cell fate decisions
    • Chi H. Regulation and function of mTOR signalling in T cell fate decisions. Nat Rev Immunol. 2011;12(5):325-338
    • (2011) Nat Rev Immunol , vol.12 , Issue.5 , pp. 325-338
    • Chi, H.1
  • 3
    • 84861719535 scopus 로고    scopus 로고
    • Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
    • Lee K, et al. Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J Exp Med. 2012;209(4):713-728
    • (2012) J Exp Med , vol.209 , Issue.4 , pp. 713-728
    • Lee, K.1
  • 5
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe GM, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30(6):832-844
    • (2009) Immunity , vol.30 , Issue.6 , pp. 832-844
    • Delgoffe, G.M.1
  • 6
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe GM, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol. 2011;12(4):295-303
    • (2011) Nat Immunol , vol.12 , Issue.4 , pp. 295-303
    • Delgoffe, G.M.1
  • 7
    • 77953897189 scopus 로고    scopus 로고
    • Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
    • Lee K, et al. Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways. Immunity. 2010;32(6):743-753
    • (2010) Immunity , vol.32 , Issue.6 , pp. 743-753
    • Lee, K.1
  • 8
    • 80051997049 scopus 로고    scopus 로고
    • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    • Yang K, Neale G, Green DR, He W, Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and shortfunction. Nat Immunol. 2011;12(9):888-897
    • (2011) Nat Immunol , vol.12 , Issue.9 , pp. 888-897
    • Yang, K.1    Neale, G.2    Green, D.R.3    He, W.4    Chi, H.5
  • 9
    • 80051617288 scopus 로고    scopus 로고
    • The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells
    • Wu Q, et al. The tuberous sclerosis complex-mammalian target of rapamycin pathway maintains the quiescence and survival of naive T cells. J Immunol. 2011;187(3):1106-1112
    • (2011) J Immunol , vol.187 , Issue.3 , pp. 1106-1112
    • Wu, Q.1
  • 10
    • 80054721266 scopus 로고    scopus 로고
    • Regulation of T-cell survival and mitochondrial homeostasis by TSC1
    • O'Brien TF, et al. Regulation of T-cell survival and mitochondrial homeostasis by TSC1. Eur J Immunol. 2011;41(11):3361-3370
    • (2011) Eur J Immunol , vol.41 , Issue.11 , pp. 3361-3370
    • O'Brien, T.F.1
  • 11
    • 84890040690 scopus 로고    scopus 로고
    • TSC1 regulates the balance between effector and regulatory T cells
    • Park Y, et al. TSC1 regulates the balance between effector and regulatory T cells. J Clin Invest. 2013; 123(12):5165-5178
    • (2013) J Clin Invest , vol.123 , Issue.12 , pp. 5165-5178
    • Park, Y.1
  • 12
    • 84873616370 scopus 로고    scopus 로고
    • CD4(+) T-cell subsets in intestinal inflammation
    • Shale M, Schiering C, Powrie F. CD4(+) T-cell subsets in intestinal inflammation. Immunol Rev. 2013;252(1):164-182
    • (2013) Immunol Rev , vol.252 , Issue.1 , pp. 164-182
    • Shale, M.1    Schiering, C.2    Powrie, F.3
  • 13
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou X, et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009;10(9):1000-1007
    • (2009) Nat Immunol , vol.10 , Issue.9 , pp. 1000-1007
    • Zhou, X.1
  • 14
    • 79958696336 scopus 로고    scopus 로고
    • Phosphoproteomic analysis iden-tifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
    • Yu Y, et al. Phosphoproteomic analysis iden- tifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science. 2011;332(6035):1322-1326
    • (2011) Science , vol.332 , Issue.6035 , pp. 1322-1326
    • Yu, Y.1
  • 15
    • 79958696694 scopus 로고    scopus 로고
    • The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling
    • Hsu PP, et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011;332(6035):1317-1322
    • (2011) Science , vol.332 , Issue.6035 , pp. 1317-1322
    • Hsu, P.P.1
  • 16
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    • Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol. 2010;11(7):618-627
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 618-627
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Paik, J.H.4    Depinho, R.A.5    Li, M.O.6
  • 17
    • 84869872964 scopus 로고    scopus 로고
    • Novel Foxo1-dependent transcriptional programs control T(reg) cell function
    • Ouyang W, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 2012;491(7425):554-559
    • (2012) Nature , vol.491 , Issue.7425 , pp. 554-559
    • Ouyang, W.1
  • 18
    • 78650085394 scopus 로고    scopus 로고
    • Foxo transcription factors control regulatory T cell development and function
    • Kerdiles YM, et al. Foxo transcription factors control regulatory T cell development and function. Immunity. 2010;33(6):890-904
    • (2010) Immunity , vol.33 , Issue.6 , pp. 890-904
    • Kerdiles, Y.M.1
  • 19
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith PM, et al. The microbial metabolites, shortfunction chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013;341(6145):569-573
    • (2013) Science , vol.341 , Issue.6145 , pp. 569-573
    • Smith, P.M.1
  • 20
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • Düvel K, et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell. 2010;39(2):171-183
    • (2010) Mol Cell , vol.39 , Issue.2 , pp. 171-183
    • Düvel, K.1
  • 21
    • 84874226167 scopus 로고    scopus 로고
    • MTOR and metabolic pathways in T cell quiescence and functional activation
    • Yang K, Chi H. mTOR and metabolic pathways in T cell quiescence and functional activation. Semin Immunol. 2012;24(6):421-428
    • (2012) Semin Immunol , vol.24 , Issue.6 , pp. 421-428
    • Yang, K.1    Chi, H.2
  • 22
    • 84879195658 scopus 로고    scopus 로고
    • MTOR and lymphocyte metabolism
    • Zeng H, Chi H. mTOR and lymphocyte metabolism. Curr Opin Immunol. 2013;25(3):347-355
    • (2013) Curr Opin Immunol , vol.25 , Issue.3 , pp. 347-355
    • Zeng, H.1    Chi, H.2
  • 23
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    • Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature. 2013;499(7459):485-490
    • (2013) Nature , vol.499 , Issue.7459 , pp. 485-490
    • Zeng, H.1    Yang, K.2    Cloer, C.3    Neale, G.4    Vogel, P.5    Chi, H.6
  • 24
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: A new generation of mTOR inhibitors
    • Benjamin D, Colombi M, Moroni C, Hall MN. Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov. 2011;10(11):868-880
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.11 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.