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Volumn 41, Issue 20, 2013, Pages 9524-9536

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE; GUANINE QUADRUPLEX; LOCKED NUCLEIC ACID; NUCLEOTIDE; PEPTIDE APTAMER; POTASSIUM ION; VASCULOTROPIN;

EID: 84890066853     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt697     Document Type: Article
Times cited : (79)

References (57)
  • 1
    • 0019570010 scopus 로고
    • Angiogenic activity from bovine retina: Partial purification and characterization
    • D'Amore, P.A., Glaser, B.M., Brunson, S.K. and Fenselau, A.H. (1981) Angiogenic activity from bovine retina: partial purification and characterization. Proc. Natl Acad. Sci. USA, 78, 3068-3072.
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 3068-3072
    • D'Amore, P.A.1    Glaser, B.M.2    Brunson, S.K.3    Fenselau, A.H.4
  • 2
  • 3
    • 0025294817 scopus 로고
    • Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy
    • Sivalingam, A., Kenney, J., Brown, G.C., Benson, W.E. and Donoso, L. (1990) Basic fibroblast growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch. Ophthalmol., 108, 869-872.
    • (1990) Arch. Ophthalmol. , vol.108 , pp. 869-872
    • Sivalingam, A.1    Kenney, J.2    Brown, G.C.3    Benson, W.E.4    Donoso, L.5
  • 4
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis, A.P., Miller, J.W., Bernal, M.T., D'Amico, D.J., Folkman, J., Yeo, T.K. and Yeo, K.T. (1994) Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol., 118, 445-450.
    • (1994) Am. J. Ophthalmol. , vol.118 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3    D'Amico, D.J.4    Folkman, J.5    Yeo, T.K.6    Yeo, K.T.7
  • 5
    • 0020681869 scopus 로고
    • The potential aggressiveness of synovial tissue in rheumatoid arthritis
    • Fassbender, H.G. and Simmling-Annefeld, M. (1983) The potential aggressiveness of synovial tissue in rheumatoid arthritis. J. Pathol., 139, 399-406.
    • (1983) J. Pathol. , vol.139 , pp. 399-406
    • Fassbender, H.G.1    Simmling-Annefeld, M.2
  • 7
  • 8
    • 0017100861 scopus 로고
    • Relation of vascular proliferation to tumor growth
    • Folkman, J. and Cotran, R. (1976) Relation of vascular proliferation to tumor growth. Int. Rev. Exp. Pathol., 16, 207-248.
    • (1976) Int. Rev. Exp. Pathol. , vol.16 , pp. 207-248
    • Folkman, J.1    Cotran, R.2
  • 9
    • 0015311426 scopus 로고
    • Anti-angiogenesis: New concept for therapy of solid tumors
    • Folkman, J. (1972) Anti-angiogenesis: new concept for therapy of solid tumors. Ann. Surg., 175, 409-416.
    • (1972) Ann. Surg. , vol.175 , pp. 409-416
    • Folkman, J.1
  • 10
    • 0043136697 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo
    • Guo, P., Fang, Q., Tao, H.Q., Schafer, C.A., Fenton, B.M., Ding, I., Hu, B. and Cheng, S.Y. (2003) Overexpression of Vascular Endothelial Growth Factor by MCF-7 Breast Cancer Cells Promotes Estrogen-independent Tumor Growth in Vivo. Cancer Res., 63, 4684-4691.
    • (2003) Cancer Res. , vol.63 , pp. 4684-4691
    • Guo, P.1    Fang, Q.2    Tao, H.Q.3    Schafer, C.A.4    Fenton, B.M.5    Ding, I.6    Hu, B.7    Cheng, S.Y.8
  • 11
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med, 1, 27-31.
    • (1995) Nat. Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 12
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery? Nat
    • Folkman, J. (2007) Angiogenesis: an organizing principle for drug discovery? Nat. Rev. Drug Discov., 6, 273-286.
    • (2007) Rev. Drug Discov. , vol.6 , pp. 273-286
    • Folkman, J.1
  • 14
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington, A.D. and Szostak, J.W. (1990) In vitro selection of RNA molecules that bind specific ligands. Nature, 346, 818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 15
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk, C. and Gold, L. (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science, 249, 505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 17
    • 34047151422 scopus 로고    scopus 로고
    • LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1
    • Lebars, I., Richard, T., Di Primo, C. and Toulmé, J.J. (2007) LNA derivatives of a kissing aptamer targeted to the trans-activating responsive RNA element of HIV-1. Blood Cells. Mol. Dis., 38, 204-209.
    • (2007) Blood Cells. Mol. Dis. , vol.38 , pp. 204-209
    • Lebars, I.1    Richard, T.2    Di Primo, C.3    Toulmé, J.J.4
  • 18
    • 67650486013 scopus 로고    scopus 로고
    • Locked nucleic acid as a novel class of therapeutic agents
    • Veedu, R.N. and Wengel, J. (2009) Locked nucleic acid as a novel class of therapeutic agents. RNA Biol., 6, 321-323.
    • (2009) RNA Biol. , vol.6 , pp. 321-323
    • Veedu, R.N.1    Wengel, J.2
  • 19
    • 77949676231 scopus 로고    scopus 로고
    • Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications
    • Veedu, R.N. and Wengel, J. (2010) Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. Chem. Biodiv., 7, 536-542.
    • (2010) Chem. Biodiv. , vol.7 , pp. 536-542
    • Veedu, R.N.1    Wengel, J.2
  • 20
    • 0037140761 scopus 로고    scopus 로고
    • Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids
    • Petersen, M., Bondensgaard, K., Wengel, J. and Jacobsen, J.P. (2002) Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA:RNA hybrids. J. Am. Chem. Soc., 124, 5974-5982.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 5974-5982
    • Petersen, M.1    Bondensgaard, K.2    Wengel, J.3    Jacobsen, J.P.4
  • 21
    • 2442695613 scopus 로고    scopus 로고
    • NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: Solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid
    • Nielsen, K.E., Rasmussen, J., Kumar, R., Wengel, J., Jacobsen, J.P. and Petersen, M. (2004) NMR Studies of Fully Modified Locked Nucleic Acid (LNA) Hybrids: solution structure of an LNA:RNA hybrid and characterization of an LNA:DNA hybrid. Bioconjugate Chem., 15, 449-457.
    • (2004) Bioconjugate Chem. , vol.15 , pp. 449-457
    • Nielsen, K.E.1    Rasmussen, J.2    Kumar, R.3    Wengel, J.4    Jacobsen, J.P.5    Petersen, M.6
  • 22
    • 67651112027 scopus 로고    scopus 로고
    • UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability
    • Langkjær, N., Pasternak, A. and Wengel, J. (2009) UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability. Bioorg. Med. Chem., 17, 5420-5425.
    • (2009) Bioorg. Med. Chem. , vol.17 , pp. 5420-5425
    • Langkjær, N.1    Pasternak, A.2    Wengel, J.3
  • 26
    • 79951575374 scopus 로고    scopus 로고
    • Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer
    • Pasternak, A., Hernandez, F.J., Rasmussen, L.M., Vester, B. and Wengel, J. (2011) Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer. Nucleic Acids Res., 39, 1155-1164.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 1155-1164
    • Pasternak, A.1    Hernandez, F.J.2    Rasmussen, L.M.3    Vester, B.4    Wengel, J.5
  • 27
    • 79961167907 scopus 로고    scopus 로고
    • Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 20-C-piperazino-UNA monomer
    • Jensen, T.B., Henriksen, J.R., Rasmussen, B.E., Rasmussen, L.M., Andresen, T.L., Wengel, J. and Pasternak, A. (2011) Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 20-C-piperazino-UNA monomer. Bioorg. Med. Chem., 19, 4739-4745.
    • (2011) Bioorg. Med. Chem. , vol.19 , pp. 4739-4745
    • Jensen, T.B.1    Henriksen, J.R.2    Rasmussen, B.E.3    Rasmussen, L.M.4    Andresen, T.L.5    Wengel, J.6    Pasternak, A.7
  • 28
    • 38049030699 scopus 로고    scopus 로고
    • Human telomere, oncogenic promoter and 50-UTR G-quadruplexes: Diverse higher order DNA and RNA targets for cancer therapeutics
    • Patel, D.J., Phan, A.T. and Kuryavyi, V. (2007) Human telomere, oncogenic promoter and 50-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res., 35, 7429-7455.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7429-7455
    • Patel, D.J.1    Phan, A.T.2    Kuryavyi, V.3
  • 29
    • 66549124907 scopus 로고    scopus 로고
    • The structures of quadruplex nucleic acids and their drug complexes
    • Neidle, S. (2009) The structures of quadruplex nucleic acids and their drug complexes. Curr. Opin. Struct. Biol., 19, 239-250.
    • (2009) Curr. Opin. Struct. Biol. , vol.19 , pp. 239-250
    • Neidle, S.1
  • 30
    • 75749091177 scopus 로고    scopus 로고
    • Screening and Improvement of an Anti-VEGF DNA Aptamer
    • Nonaka, Y., Sode, K. and Ikebukuro, K. (2010) Screening and Improvement of an Anti-VEGF DNA Aptamer. Molecules, 15, 215-225.
    • (2010) Molecules , vol.15 , pp. 215-225
    • Nonaka, Y.1    Sode, K.2    Ikebukuro, K.3
  • 31
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D.W., Cachianes, G., Kuang, W.J., Goeddel, D.V. and Ferrara, N. (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 246, 1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 32
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Keck, P.J., Hauser, S.D., Krivi, G., Sanzo, K., Warren, T., Feder, J. and Connolly, D.T. (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science, 246, 1309-1312.
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6    Connolly, D.T.7
  • 33
    • 70349785011 scopus 로고    scopus 로고
    • Solution structure of a locked nucleic acid modified quadruplex: Introducing the V4 folding topology
    • Nielsen, J.T., Arar, K. and Petersen, M. (2009) Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology. Angew. Chem. Int. Ed., 48, 3099-3103.
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 3099-3103
    • Nielsen, J.T.1    Arar, K.2    Petersen, M.3
  • 34
    • 34247160470 scopus 로고    scopus 로고
    • Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter
    • Phan, A.T., Kuryavyi, V., Burge, S., Neidle, S. and Patel, D.J. (2007) Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J. Am. Chem. Soc., 129, 4386-4392.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 4386-4392
    • Phan, A.T.1    Kuryavyi, V.2    Burge, S.3    Neidle, S.4    Patel, D.J.5
  • 35
    • 33644833219 scopus 로고    scopus 로고
    • Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
    • Phan, A.T., Kuryavyi, V., Gaw, H.Y. and Patel, D.J. (2005) Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter. Nat. Chem. Biol., 1, 167-173.
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 167-173
    • Phan, A.T.1    Kuryavyi, V.2    Gaw, H.Y.3    Patel, D.J.4
  • 36
    • 0038202304 scopus 로고    scopus 로고
    • Small change in a G-rich sequence, a dramatic change in topology: New dimeric G-quadruplex folding motif with unique loop orientations
    • Crnugelj, M., Sket, P. and Plavec, J. (2003) Small change in a G-rich sequence, a dramatic change in topology: new dimeric G-quadruplex folding motif with unique loop orientations. J. Am. Chem. Soc., 125, 7866-7871.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 7866-7871
    • Crnugelj, M.1    Sket, P.2    Plavec, J.3
  • 37
    • 84864959586 scopus 로고    scopus 로고
    • Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops
    • Marušič, M., Šket, P., Bauer, L., Viglasky, V. and Plavec, J. (2012) Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops. Nucleic Acids Res., 40, 6946-6956.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 6946-6956
    • Marušič, M.1    Šket, P.2    Bauer, L.3    Viglasky, V.4    Plavec, J.5
  • 39
    • 0029400480 scopus 로고
    • NMRPipe: A multidimensional spectral processing system based on UNIX pipes
    • Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu, G., Pfeifer, J. and Bax, A. (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. Nmr, 6, 277-293.
    • (1995) J. Biomol. Nmr , vol.6 , pp. 277-293
    • Delaglio, F.1    Grzesiek, S.2    Vuister, G.W.3    Zhu, G.4    Pfeifer, J.5    Bax, A.6
  • 41
    • 34250318638 scopus 로고    scopus 로고
    • Refinement of the AMBER force field for nucleic acids: Improving the description of alpha/ gamma conformers
    • Pérez, A., Marchán, I., Svozil, D., Sponer, J., Cheatham, T.E. III, Laughton, C.A. and Orozco, M. (2007) Refinement of the AMBER force field for nucleic acids: improving the description of alpha/ gamma conformers. Biophys. J., 92, 3817-3829.
    • (2007) Biophys. J. , vol.92 , pp. 3817-3829
    • Pérez, A.1    Marchán, I.2    Svozil, D.3    Sponer, J.4    Cheatham III, T.E.5    Laughton, C.A.6    Orozco, M.7
  • 43
    • 0242396923 scopus 로고    scopus 로고
    • 3DNA: A software package for the analysis, rebuilding and visualization of three dimensional nucleic acid structures
    • Lu, X.J. and Olson, W.K. (2003) 3DNA: a software package for the analysis, rebuilding and visualization of three dimensional nucleic acid structures. Nucleic Acids Res., 31, 5108-5121.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 5108-5121
    • Lu, X.J.1    Olson, W.K.2
  • 44
    • 50349085962 scopus 로고    scopus 로고
    • 3DNA: A versatile, integrated software system for the analysis, rebuilding and visualization of three-dimensional nucleic-acid structures
    • Lu, X.J. and Olson, W.K. (2008) 3DNA: a versatile, integrated software system for the analysis, rebuilding and visualization of three-dimensional nucleic-acid structures. Nat. Protocols, 3, 1213-1227.
    • (2008) Nat. Protocols , vol.3 , pp. 1213-1227
    • Lu, X.J.1    Olson, W.K.2
  • 45
    • 33645809523 scopus 로고    scopus 로고
    • NMR solution structures of LNA (locked nucleic acid) modified quadruplexes
    • Nielsen, J.T., Arar, K. and Petersen, M. (2006) NMR solution structures of LNA (locked nucleic acid) modified quadruplexes. Nucleic Acids Res., 34, 2006-2014.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2006-2014
    • Nielsen, J.T.1    Arar, K.2    Petersen, M.3
  • 46
    • 37249066753 scopus 로고    scopus 로고
    • Geometric formalism for DNA quadruplex folding
    • Webba da Silva, M. (2007) Geometric formalism for DNA quadruplex folding. Chem. Eur. J., 13, 9738-9745.
    • (2007) Chem. Eur. J. , vol.13 , pp. 9738-9745
    • Webba Da Silva, M.1
  • 47
    • 80455129678 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges
    • Mukundan, V.T., Do, N.Q. and Phan, A.T. (2011) HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges. Nucleic Acids Res., 39, 8984-8991.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 8984-8991
    • Mukundan, V.T.1    Do, N.Q.2    Phan, A.T.3
  • 48
    • 73449099245 scopus 로고    scopus 로고
    • Solution structure of a unique G-quadruplex scaffold adopted by a guanosine-rich human intronic sequence
    • Kuryavyi, V. and Patel, D.J. (2010) Solution structure of a unique G-quadruplex scaffold adopted by a guanosine-rich human intronic sequence. Structure, 18, 73-82.
    • (2010) Structure , vol.18 , pp. 73-82
    • Kuryavyi, V.1    Patel, D.J.2
  • 49
    • 3242666778 scopus 로고    scopus 로고
    • Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
    • Phan, A.T., Modi, Y.S. and Patel, D.J. (2004) Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J. Am. Chem. Soc., 126, 8710-8716.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 8710-8716
    • Phan, A.T.1    Modi, Y.S.2    Patel, D.J.3
  • 51
    • 33646943863 scopus 로고    scopus 로고
    • Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/ antiparallel strands in potassium solution
    • Ambrus, A., Chen, D., Dai, J., Bialis, T., Jones, R.A. and Yang, D. (2006) Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/ antiparallel strands in potassium solution. Nucleic Acids Res., 34, 2723-2735.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2723-2735
    • Ambrus, A.1    Chen, D.2    Dai, J.3    Bialis, T.4    Jones, R.A.5    Yang, D.6
  • 52
    • 33746600695 scopus 로고    scopus 로고
    • Structure of the human telomere in K+ solution: An intramolecular (3+1) G-quadruplex scaffold
    • Luu, K.N., Phan, A.T., Kuryavyi, V., Lacroix, L. and Patel, D.J. (2006) Structure of the human telomere in K+ solution: an intramolecular (3+1) G-quadruplex scaffold. J. Am. Chem. Soc., 128, 9963-9970.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 9963-9970
    • Luu, K.N.1    Phan, A.T.2    Kuryavyi, V.3    Lacroix, L.4    Patel, D.J.5
  • 53
    • 47249089205 scopus 로고    scopus 로고
    • Structural polymorphism of intramolecular quadruplex of human telomeric DNA: Effect of cations, quadruplex-binding drugs and flanking sequences
    • Gaynutdinov, T.I., Neumann, R.D. and Panyutin, I.G. (2008) Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences. Nucleic Acids Res., 36, 4079-4087.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4079-4087
    • Gaynutdinov, T.I.1    Neumann, R.D.2    Panyutin, I.G.3
  • 54
    • 79953700299 scopus 로고    scopus 로고
    • Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids
    • Pedersen, E.B., Nielsen, J.T., Nielsen, C. and Filichev, V.V. (2011) Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids. Nucleic Acids Res., 39, 2470-2481.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 2470-2481
    • Pedersen, E.B.1    Nielsen, J.T.2    Nielsen, C.3    Filichev, V.V.4
  • 55
    • 79951666715 scopus 로고    scopus 로고
    • Selection of G-quadruplex folding topology with LNA-modified human telomeric sequences in K+ solution
    • Pradhan, D., Hansen, L.H., Vester, B. and Petersen, M. (2011) Selection of G-quadruplex folding topology with LNA-modified human telomeric sequences in K+ solution. Chem. Eur. J., 17, 2405-2413.
    • (2011) Chem. Eur. J. , vol.17 , pp. 2405-2413
    • Pradhan, D.1    Hansen, L.H.2    Vester, B.3    Petersen, M.4
  • 57
    • 41649095687 scopus 로고    scopus 로고
    • Effect of locked-nucleic acid on a biologically active G-quadruplex. A structure-activity relationship of the thrombin aptamer
    • Bonifacio, L., Church, F.C. and Jarstfer, M.B. (2008) Effect of locked-nucleic acid on a biologically active G-quadruplex. A structure-activity relationship of the thrombin aptamer. Int. J. Mol. Sci., 9, 422-433.
    • (2008) Int. J. Mol. Sci. , vol.9 , pp. 422-433
    • Bonifacio, L.1    Church, F.C.2    Jarstfer, M.B.3


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