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Volumn 39, Issue 20, 2011, Pages 8984-8991

HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE QUADRUPLEX; INTEGRASE; INTEGRASE INHIBITOR; OLIGONUCLEOTIDE; THYMINE; ZINTEVIR;

EID: 80455129678     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkr540     Document Type: Article
Times cited : (90)

References (50)
  • 1
    • 1042268168 scopus 로고    scopus 로고
    • G-quartets 40 years later: From 5'-GMP to molecular biology and supramolecular chemistry
    • Davis, J.T. (2004) G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Angew. Chem. Int. Ed. Engl., 43, 668-698.
    • (2004) Angew. Chem. Int. Ed. Engl. , vol.43 , pp. 668-698
    • Davis, J.T.1
  • 4
    • 38049030699 scopus 로고    scopus 로고
    • Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: Diverse higher order DNA and RNA targets for cancer therapeutics
    • Patel, D.J., Phan, A.T. and Kuryavyi, V. (2007) Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res., 35, 7429-7455.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7429-7455
    • Patel, D.J.1    Phan, A.T.2    Kuryavyi, V.3
  • 5
    • 66549124907 scopus 로고    scopus 로고
    • The structures of quadruplex nucleic acids and their drug complexes
    • Neidle, S. (2009) The structures of quadruplex nucleic acids and their drug complexes. Curr. Opin. Struct. Biol., 19, 239-250.
    • (2009) Curr. Opin. Struct. Biol. , vol.19 , pp. 239-250
    • Neidle, S.1
  • 6
    • 33845352895 scopus 로고    scopus 로고
    • Dynamic roles for G4 DNA in the biology of eukaryotic cells
    • Maizels, N. (2006) Dynamic roles for G4 DNA in the biology of eukaryotic cells. Nat. Struct. Mol. Biol., 13, 1055-1059.
    • (2006) Nat. Struct. Mol. Biol. , vol.13 , pp. 1055-1059
    • Maizels, N.1
  • 7
    • 0033543548 scopus 로고    scopus 로고
    • Antiproliferative activity of G-rich oligonucleotides correlates with protein binding
    • Bates, P.J., Kahlon, J.B., Thomas, S.D., Trent, J.O. and Miller, D.M. (1999) Antiproliferative activity of G-rich oligonucleotides correlates with protein binding. J. Biol. Chem., 274, 26369-26377.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26369-26377
    • Bates, P.J.1    Kahlon, J.B.2    Thomas, S.D.3    Trent, J.O.4    Miller, D.M.5
  • 8
    • 4644325545 scopus 로고    scopus 로고
    • G-quartet oligonucleotides: A new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis
    • Jing, N., Li, Y., Xiong, W., Sha, W., Jing, L. and Tweardy, D.J. (2004) G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer Res., 64, 6603-6609.
    • (2004) Cancer Res. , vol.64 , pp. 6603-6609
    • Jing, N.1    Li, Y.2    Xiong, W.3    Sha, W.4    Jing, L.5    Tweardy, D.J.6
  • 12
    • 0028961595 scopus 로고
    • Suppression of human immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads
    • Rando, R.F., Ojwang, J., Elbaggari, A., Reyes, G.R., Tinder, R., McGrath, M.S. and Hogan, M.E. (1995) Suppression of human immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads. J. Biol. Chem., 270, 1754-1760.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1754-1760
    • Rando, R.F.1    Ojwang, J.2    Elbaggari, A.3    Reyes, G.R.4    Tinder, R.5    McGrath, M.S.6    Hogan, M.E.7
  • 13
    • 0029964978 scopus 로고    scopus 로고
    • Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures
    • Mazumder, A., Neamati, N., Ojwang, J.O., Sunder, S., Rando, R.F. and Pommier, Y. (1996) Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures. Biochemistry, 35, 13762-13771.
    • (1996) Biochemistry , vol.35 , pp. 13762-13771
    • Mazumder, A.1    Neamati, N.2    Ojwang, J.O.3    Sunder, S.4    Rando, R.F.5    Pommier, Y.6
  • 14
    • 0030764882 scopus 로고    scopus 로고
    • Ion selective folding of loop domains in a potent anti-HIV oligonucleotide
    • Jing, N., Rando, R.F., Pommier, Y. and Hogan, M.E. (1997) Ion selective folding of loop domains in a potent anti-HIV oligonucleotide. Biochemistry, 36, 12498-12505.
    • (1997) Biochemistry , vol.36 , pp. 12498-12505
    • Jing, N.1    Rando, R.F.2    Pommier, Y.3    Hogan, M.E.4
  • 15
    • 0034647554 scopus 로고    scopus 로고
    • Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in vitro
    • Jing, N.J., Marchand, C., Liu, J., Mitra, R., Hogan, M.E. and Pommier, Y. (2000) Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in vitro. J. Biol. Chem., 275, 21460-21467.
    • (2000) J. Biol. Chem. , vol.275 , pp. 21460-21467
    • Jing, N.J.1    Marchand, C.2    Liu, J.3    Mitra, R.4    Hogan, M.E.5    Pommier, Y.6
  • 17
    • 14144254793 scopus 로고    scopus 로고
    • An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase
    • Phan, A.T., Kuryavyi, V., Ma, J.B., Faure, A., Andreola, M.L. and Patel, D.J. (2005) An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. Proc. Natl Acad. Sci. USA, 102, 634-639.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 634-639
    • Phan, A.T.1    Kuryavyi, V.2    Ma, J.B.3    Faure, A.4    Andreola, M.L.5    Patel, D.J.6
  • 18
    • 58749093598 scopus 로고    scopus 로고
    • Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases
    • Michalowski, D., Chitima-Matsiga, R., Held, D.M. and Burke, D.H. (2008) Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases. Nucleic Acids Res., 36, 7124-7135.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 7124-7135
    • Michalowski, D.1    Chitima-Matsiga, R.2    Held, D.M.3    Burke, D.H.4
  • 22
    • 0242710951 scopus 로고    scopus 로고
    • Crystal structure of a bulged RNA tetraplex at 1.1 angstrom resolution: Implications for a novel binding site in RNA tetraplex
    • Pan, B.C., Xiong, Y., Shi, K. and Sundaralingam, M. (2003) Crystal structure of a bulged RNA tetraplex at 1.1 angstrom resolution: Implications for a novel binding site in RNA tetraplex. Structure, 11, 1423-1430.
    • (2003) Structure , vol.11 , pp. 1423-1430
    • Pan, B.C.1    Xiong, Y.2    Shi, K.3    Sundaralingam, M.4
  • 23
    • 0031439074 scopus 로고    scopus 로고
    • Biologically active oligodeoxyribonucleotides-IX. Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, T GGGAG, bearing 3'- and 5'-end-modification
    • Koizumi, M., Koga, R., Hotoda, H., Momota, K., Ohmine, T., Furukawa, H., Agatsuma, T., Nishigaki, T., Abe, K., Kosaka, T. et al. (1997) Biologically active oligodeoxyribonucleotides-IX. Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, T GGGAG, bearing 3'- and 5'-end-modification. Bioorg. Med. Chem., 5, 2235-2243.
    • (1997) Bioorg. Med. Chem. , vol.5 , pp. 2235-2243
    • Koizumi, M.1    Koga, R.2    Hotoda, H.3    Momota, K.4    Ohmine, T.5    Furukawa, H.6    Agatsuma, T.7    Nishigaki, T.8    Abe, K.9    Kosaka, T.10
  • 24
    • 0348111401 scopus 로고    scopus 로고
    • Anti-HIV-1 activity and mode of action of mirror image oligodeoxynucleotide analogue of Zintevir
    • Urata, H., Kumashiro, T., Kawahata, T., Otake, T. and Akagi, M. (2004) Anti-HIV-1 activity and mode of action of mirror image oligodeoxynucleotide analogue of Zintevir. Biochem. Biophys. Res. Commun., 313, 55-61.
    • (2004) Biochem. Biophys. Res. Commun. , vol.313 , pp. 55-61
    • Urata, H.1    Kumashiro, T.2    Kawahata, T.3    Otake, T.4    Akagi, M.5
  • 25
    • 79953700299 scopus 로고    scopus 로고
    • Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids
    • Pedersen, E.B., Nielsen, J.T., Nielsen, C. and Filichev, V.V. (2011) Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids. Nucleic Acids Res., 39, 2470-2481.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 2470-2481
    • Pedersen, E.B.1    Nielsen, J.T.2    Nielsen, C.3    Filichev, V.V.4
  • 26
    • 0035968306 scopus 로고    scopus 로고
    • HIV integrase, a brief overview from chemistry to therapeutics
    • Craigie, R. (2001) HIV integrase, a brief overview from chemistry to therapeutics. J. Biol. Chem., 276, 23213-23216.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23213-23216
    • Craigie, R.1
  • 27
    • 0031469736 scopus 로고    scopus 로고
    • Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide
    • Jing, N., Gao, X., Rando, R.F. and Hogan, M.E. (1997) Potassium-induced loop conformational transition of a potent anti-HIV oligonucleotide. J. Biomol. Struct. Dyn., 15, 573-585.
    • (1997) J. Biomol. Struct. Dyn. , vol.15 , pp. 573-585
    • Jing, N.1    Gao, X.2    Rando, R.F.3    Hogan, M.E.4
  • 28
    • 41149139667 scopus 로고    scopus 로고
    • Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by electrospray ionization mass spectrometry
    • Li, H., Yuan, G. and Du, D. (2008) Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by electrospray ionization mass spectrometry. J. Am. Soc. Mass. Spectrom., 19, 550-559.
    • (2008) J. Am. Soc. Mass. Spectrom. , vol.19 , pp. 550-559
    • Li, H.1    Yuan, G.2    Du, D.3
  • 31
    • 3242666778 scopus 로고    scopus 로고
    • Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter
    • Phan, A.T., Modi, Y.S. and Patel, D.J. (2004) Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J. Am. Chem. Soc., 126, 8710-8716.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 8710-8716
    • Phan, A.T.1    Modi, Y.S.2    Patel, D.J.3
  • 34
    • 34547646128 scopus 로고    scopus 로고
    • Intramolecular DNA quadruplexes with different arrangements of short and long loops
    • Rachwal, P.A., Findlow, I.S., Werner, J.M., Brown, T. and Fox, K.R. (2007) Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Res., 35, 4214-4222.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 4214-4222
    • Rachwal, P.A.1    Findlow, I.S.2    Werner, J.M.3    Brown, T.4    Fox, K.R.5
  • 35
    • 38849085810 scopus 로고    scopus 로고
    • A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes
    • Bugaut, A. and Balasubramanian, S. (2008) A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes. Biochemistry, 47, 689-697.
    • (2008) Biochemistry , vol.47 , pp. 689-697
    • Bugaut, A.1    Balasubramanian, S.2
  • 36
    • 43049132871 scopus 로고    scopus 로고
    • Sequence effects in single-base loops for quadruplexes
    • Guedin, A., De Cian, A., Gros, J., Lacroix, L. and Mergny, J.-L. (2008) Sequence effects in single-base loops for quadruplexes. Biochimie, 90, 686-696.
    • (2008) Biochimie , vol.90 , pp. 686-696
    • Guedin, A.1    De Cian, A.2    Gros, J.3    Lacroix, L.4    Mergny, J.-L.5
  • 37
    • 78649850820 scopus 로고    scopus 로고
    • How long is too long? Effects of loop size on G-quadruplex stability
    • Guedin, A., Gros, J., Alberti, P. and Mergny, J.L. (2010) How long is too long? Effects of loop size on G-quadruplex stability. Nucleic Acids Res., 38, 7858-7868.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 7858-7868
    • Guedin, A.1    Gros, J.2    Alberti, P.3    Mergny, J.L.4
  • 38
    • 77954616527 scopus 로고    scopus 로고
    • The 3D structures of G-Quadruplexes of HIV-1 integrase inhibitors: Molecular dynamics simulations in aqueous solution and in the gas phase
    • Li, M.H., Zhou, Y.H., Luo, Q. and Li, Z.S. (2010) The 3D structures of G-Quadruplexes of HIV-1 integrase inhibitors: molecular dynamics simulations in aqueous solution and in the gas phase. J. Mol. Model., 16, 645-657.
    • (2010) J. Mol. Model. , vol.16 , pp. 645-657
    • Li, M.H.1    Zhou, Y.H.2    Luo, Q.3    Li, Z.S.4
  • 39
    • 80455170603 scopus 로고    scopus 로고
    • Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity
    • doi:10.1093/nar/gkr539
    • Do, N.Q., Lim, K.W., Teo, M.H., Heddi, B. and Phan, A.T. (2011) Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity. Nucleic Acids Res. (doi:10.1093/nar/gkr539).
    • (2011) Nucleic Acids Res.
    • Do, N.Q.1    Lim, K.W.2    Teo, M.H.3    Heddi, B.4    Phan, A.T.5
  • 40
    • 0014725117 scopus 로고
    • Oligonucleotide interactions. 3. Circular dichroism studies of the conformation of deoxyoligonucleotides
    • Cantor, C.R., Warshaw, M.M. and Shapiro, H. (1970) Oligonucleotide interactions. 3. Circular dichroism studies of the conformation of deoxyoligonucleotides. Biopolymers, 9, 1059-1077.
    • (1970) Biopolymers , vol.9 , pp. 1059-1077
    • Cantor, C.R.1    Warshaw, M.M.2    Shapiro, H.3
  • 41
    • 0037138634 scopus 로고    scopus 로고
    • A site-specific low-enrichment (15)N, (13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids
    • Phan, A.T. and Patel, D.J. (2002) A site-specific low-enrichment (15)N, (13)C isotope-labeling approach to unambiguous NMR spectral assignments in nucleic acids. J. Am. Chem. Soc., 124, 1160-1161.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 1160-1161
    • Phan, A.T.1    Patel, D.J.2
  • 42
    • 0030661609 scopus 로고    scopus 로고
    • An efficient and economic site-specific deuteration strategy for NMR studies of homologous oligonucleotide repeat sequences
    • Huang, X.N., Yu, P.L., LeProust, E. and Gao, X.L. (1997) An efficient and economic site-specific deuteration strategy for NMR studies of homologous oligonucleotide repeat sequences. Nucleic Acids Res., 25, 4758-4763.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 4758-4763
    • Huang, X.N.1    Yu, P.L.2    Leproust, E.3    Gao, X.L.4
  • 43
    • 0034090950 scopus 로고    scopus 로고
    • Long-range imino proton-13C J-couplings and the through-bond correlation of imino and non-exchangeable protons in unlabeled DNA
    • Phan, A.T. (2000) Long-range imino proton-13C J-couplings and the through-bond correlation of imino and non-exchangeable protons in unlabeled DNA. J. Biomol. NMR, 16, 175-178.
    • (2000) J. Biomol. NMR , vol.16 , pp. 175-178
    • Phan, A.T.1
  • 44
    • 0034924446 scopus 로고    scopus 로고
    • Investigation of unusual DNA motifs
    • Phan, A.T., Gueron, M. and Leroy, J.L. (2001) Investigation of unusual DNA motifs. Methods Enzymol., 338, 341-371.
    • (2001) Methods Enzymol. , vol.338 , pp. 341-371
    • Phan, A.T.1    Gueron, M.2    Leroy, J.L.3
  • 45
    • 0032508468 scopus 로고    scopus 로고
    • Following G-quartet formation by UV-spectroscopy
    • Mergny, J.L., Phan, A.T. and Lacroix, L. (1998) Following G-quartet formation by UV-spectroscopy. FEBS Lett., 435, 74-78.
    • (1998) FEBS Lett. , vol.435 , pp. 74-78
    • Mergny, J.L.1    Phan, A.T.2    Lacroix, L.3
  • 46
    • 0023406843 scopus 로고
    • Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves
    • Marky, L.A. and Breslauer, K.J. (1987) Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves. Biopolymers, 26, 1601-1620.
    • (1987) Biopolymers , vol.26 , pp. 1601-1620
    • Marky, L.A.1    Breslauer, K.J.2
  • 47
    • 0025202253 scopus 로고
    • Tetraplex formation of a guanine-containing nonameric DNA fragment
    • Jin, R.Z., Breslauer, K.J., Jones, R.A. and Gaffney, B.L. (1990) Tetraplex formation of a guanine-containing nonameric DNA fragment. Science, 250, 543-546.
    • (1990) Science , vol.250 , pp. 543-546
    • Jin, R.Z.1    Breslauer, K.J.2    Jones, R.A.3    Gaffney, B.L.4
  • 48
    • 77956252000 scopus 로고    scopus 로고
    • Coexistence of two distinct G-quadruplex conformations in the hTERT promoter
    • Lim, K.W., Lacroix, L., Yue, D.J., Lim, J.K., Lim, J.M. and Phan, A.T. (2010) Coexistence of two distinct G-quadruplex conformations in the hTERT promoter. J. Am. Chem. Soc., 132, 12331-12342.
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 12331-12342
    • Lim, K.W.1    Lacroix, L.2    Yue, D.J.3    Lim, J.K.4    Lim, J.M.5    Phan, A.T.6
  • 49
    • 0027240171 scopus 로고
    • Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution
    • Smith, F.W. and Feigon, J. (1993) Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution. Biochemistry, 32, 8682-8692.
    • (1993) Biochemistry , vol.32 , pp. 8682-8692
    • Smith, F.W.1    Feigon, J.2
  • 50
    • 70350692142 scopus 로고    scopus 로고
    • Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad
    • Lim, K.W., Alberti, P., Guedin, A., Lacroix, L., Riou, J.F., Royle, N.J., Mergny, J.L. and Phan, A.T. (2009) Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad. Nucleic Acids Res., 37, 6239-6248.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 6239-6248
    • Lim, K.W.1    Alberti, P.2    Guedin, A.3    Lacroix, L.4    Riou, J.F.5    Royle, N.J.6    Mergny, J.L.7    Phan, A.T.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.