Alantolactone induces cell apoptosis partially through down-regulation of testes-specific protease 50 expression

Toxicology Letters

Volumn 224, Issue 3, 2014, Pages 349-355

  Mi, Xu Guang ^a   Song, Zhen Bo ^a   Wu, Ping ^a   Zhang, Yu Wei ^a   Sun, Lu Guo ^a   Bao, Yong Li ^a   Zhang, Yu ^a   Zheng, Li Hua ^a   Sun, Ying ^a   Yu, Chun Lei ^a   Wu, Yin ^a   Wang, Guan Nan ^a   Li, Yu Xin ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

Alantolactone; Anticancer; Apoptosis; Drug screening; TSP50 inhibitor

Indexed keywords

ALANTOLACTONE; CASPASE 3; CASPASE 9; FIREFLY LUCIFERASE; MESSENGER RNA; NATURAL PRODUCT; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TESTES SPECIFIC PROTEASE 50; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CHINESE MEDICINE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 84890054965     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.11.002     Document Type: Article

References (35)

1. Adams J.M., Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 2001, 26:61-66.
2. Antonsson B. Bax and other pro-apoptotic Bcl-2 family killer-proteins and their victim the mitochondrion. Cell Tissue Res. 2001, 306:347-361.
3. Aouida M., Mekid H., Belhadj O., Mir L.M., Tounekti O. Mitochondria-independent morphological and biochemical apoptotic alterations promoted by the anti-tumor agent bleomycin in Saccharomyces cerevisiae. Biochem. Cell Biol. 2007, 85:49-55.
4. Craig W.J. Health-promoting properties of common herbs. Am. J. Clin. Nutr. 1999, 70:491S-499S.
5. Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer 2010, 127:2893-2917.
6. Hockenbery D.M., Oltvai Z.N., Yin X.M., Milliman C.L., Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993, 75:241-251.
7. Khan M., Yi F., Rasul A., Li T., Wang N., Gao H., Gao R., Ma T. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 2012, 64:783-794.
8. Konishi T., Shimada Y., Nagao T., Okabe H., Konoshima T. Antiproliferative sesquiterpene lactones from the roots of Inula helenium. Biol. Pharm. Bull. 2002, 25:1370-1372.
9. Lawrence N.J., McGown A.T., Nduka J., Hadfield J.A., Pritchard R.G. Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone. Bioorg. Med. Chem. Lett. 2001, 11:429-431.
10. Lei J.C., Yu J.Q., Yin Y., Liu Y.W., Zou G.L. Alantolactone induces activation of apoptosis in human hepatoma cells. Food Chem. Toxicol. 2012, 50:3313-3319.
11. Li Y.Y., Bao Y.L., Song Z.B., Sun L.G., Wu P., Zhang Y., Fan C., Huang Y.X., Wu Y., Yu C.L., Sun Y., Zheng L.H., Wang G.N., Li Y.X. The threonine protease activity of testes-specific protease 50 (TSP50) is essential for its function in cell proliferation. PLoS ONE 2012, 7:e35030.
12. Lin L.Y., Bao Y.L., Chen Y., Sun L.G., Yang X.G., Liu B., Lin Z.X., Zhang Y.W., Yu C.L., Wu Y., Li Y.X. N-Benzoyl-12-nitrodehydroabietylamine-7-one, a novel dehydroabietylamine derivative, induces apoptosis and inhibits proliferation in HepG2 cells. Chem. Biol. Interact. 2012, 199:63-73.
13. Liu Y., Bao Y.L., Yu C.L., Wu Y., Yang X.G., Xu H.P., Sun Y., Li Y.X. Development and characterization of monoclonal antibody specifically against TSP50. Chem. Res. Chin. Univ. 2009, 25:483-486.
14. Mayer B., Oberbauer R. Mitochondrial regulation of apoptosis. News Physiol. Sci. 2003, 18:89-94.
15. Negoescu A., Lorimier P., Labat-Moleur F., Drouet C., Robert C., Guillermet C., Brambilla C., Brambilla E. In situ apoptotic cell labeling by the TUNEL method: improvement and evaluation on cell preparations. J. Histochem. Cytochem. 1996, 44:959-968.
16. Ocana A., Pandiella A., Siu L.L., Tannock I.F. Preclinical development of molecular-targeted agents for cancer. Nat. Rev. Clin. Oncol. 2011, 8:200-209.
17. Shan J., Yuan L., Xiao Q., Chiorazzi N., Budman D., Teichberg S., Xu H.P. TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells. Cancer Res. 2002, 62:290-294.
18. Shi Y., Bao Y.L., Wu Y., Yu C.L., Huang Y.X., Sun Y., Zheng L.H., Li Y.X. Alantolactone inhibits cell proliferation by interrupting the interaction between cripto-1 and activin receptor type II A in activin signaling pathway. J. Biomol. Screen. 2011, 16:525-535.
19. Song Z.B., Bao Y.L., Zhang Y., Mi X.G., Wu P., Wu Y., Yu C.L., Sun Y., Zheng L.H., Huang Y.X., Liu B., Li Y.X. Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor kappaB (NF-kappaB) signalling pathway. Biochem. J. 2011, 436:457-467.
20. Stojakowska A., Michalska K., Malarz J. Simultaneous quantification of eudesmanolides and thymol derivatives from tissues of Inula helenium and I. royleana by reversed-phase high-performance liquid chromatography. Phytochem. Anal. 2006, 17:157-161.
21. Sun B.T., Zheng L.H., Bao Y.L., Yu C.L., Wu Y., Meng X.Y., Li Y.X. Reversal effect of dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells. Eur. J. Pharmacol. 2011, 654:129-134.
22. Trendafilova A., Chanev C., Todorova M. Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots. Pharmacogn. Mag. 2010, 6:234-237.
23. Vander Heiden M.G., Thompson C.B. Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?. Nat. Cell Biol. 1999, 1:E209-E216.
24. Walker J.A., Quirke P. Viewing apoptosis through a 'TUNEL'. J. Pathol. 2001, 195:275-276.
25. Wang M., Bao Y.L., Wu Y., Yu C.L., Meng X., Xu H.P., Li Y.X. Identification and characterization of the human testes-specific protease 50 gene promoter. DNA Cell Biol. 2008, 27:307-314.
26. Wang M., Bao Y.L., Wu Y., Yu C.L., Meng X.Y., Huang Y.X., Sun Y., Zheng L.H., Li Y.X. Basic FGF downregulates TSP50 expression via the ERK/Sp1 pathway. J. Cell Biochem. 2010, 111:75-81.
27. Wang Z., Wang N., Chen J., Shen J. Emerging glycolysis targeting and drug discovery from Chinese medicine in cancer therapy. Evid. Based Complement. Alternat. Med. 2012, 2012:873175.
28. Xu H., Shan J., Jurukovski V., Yuan L., Li J., Tian K. TSP50 encodes a testis-specific protease and is negatively regulated by p53. Cancer Res. 2007, 67:1239-1245.
29. Xu H.P., Yuan L., Shan J., Feng H. Localization and expression of TSP50 protein in human and rodent testes. Urology 2004, 64:826-832.
30. Xu W., Towers A.D., Li P., Collet J.P. Traditional Chinese medicine in cancer care: perspectives and experiences of patients and professionals in China. Eur. J. Cancer Care (Engl) 2006, 15:397-403.
31. Yuan L., Shan J., De Risi D., Broome J., Lovecchio J., Gal D., Vinciguerra V., Xu H.P. Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer. Cancer Res. 1999, 59:3215-3221.
32. Zhang Y., Bao Y.L., Wu Y., Yu C.L., Sun Y., Li Y.X. Identification and characterization of the human SLC5A8 gene promoter. Cancer Genet. Cytogenet. 2010, 196:124-132.
33. Zhang Y., Zhou L., Bao Y.L., Wu Y., Yu C.L., Huang Y.X., Sun Y., Zheng L.H., Li Y.X. Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells. Chem. Biol. Interact. 2010, 185:174-181.
34. Zheng L., Xie G., Duan G., Yan X., Li Q. High expression of testes-specific protease 50 is associated with poor prognosis in colorectal carcinoma. PLoS ONE 2011, 6:e22203.
35. Zhou L., Bao Y.L., Zhang Y., Wu Y., Yu C.L., Huang Y.X., Sun Y., Zheng L.H., Li Y.X. Knockdown of TSP50 inhibits cell proliferation and induces apoptosis in P19 cells. IUBMB Life 2010, 62:825-832.