N-Benzoyl-12-nitrodehydroabietylamine-7-one, a novel dehydroabietylamine derivative, induces apoptosis and inhibits proliferation in HepG2 cells

Chemico-Biological Interactions

Volumn 199, Issue 2, 2012, Pages 63-73

  Lin, Ling Ying ^a   Bao, Yong Li ^a   Chen, Yong ^c   Sun, Lu Guo ^a   Yang, Xiao Guang ^a   Liu, Biao ^b   Lin, Zhong Xiang ^c   Zhang, Yu Wei ^a   Yu, Chun Lei ^a   Wu, Yin ^a   Li, Yu Xin ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c NANJING FORESTRY UNIVERSITY   (China)

Author keywords

Apoptosis; HepG2; N Benzoyl 12 nitrodehydroabietylamine 7 one; Proliferation; Structural activity relationship

Indexed keywords

ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; DEHYDROABIETYLAMINE DERIVATIVE; KI 67 ANTIGEN; N BENZOYL 12 NITRODEHYDROABIETYLAMINE 7 ONE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; NICK END LABELING; PERIODIC ACID SCHIFF STAIN; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; DITERPENES; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864399367     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.06.002     Document Type: Article

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