Effects of age and sex on the concentrations of glutamate and glutamine in the human brain

Journal of Magnetic Resonance Imaging

Volumn 38, Issue 6, 2013, Pages 1480-1487

  Hädel, Sven ^a   Wirth, Christoph ^a   Rapp, Michael ^a   Gallinat, Jürgen ^a   Schubert, Florian ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b PHYSIKALISCH TECHNISCHE BUNDESANSTALT   (Germany)

Author keywords

age; brain metabolites; glutamate; glutamine; magnetic resonance spectroscopy; sex

Indexed keywords

CHOLINE; CREATINE; GLUTAMIC ACID; GLUTAMINE; N ACETYLASPARTIC ACID;

ADULT; AGE; ANTERIOR CINGULATE; ARTICLE; BRAIN LEVEL; BRAIN REGION; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SEX; SEX DIFFERENCE; SPECTROSCOPY;

AGE; BRAIN METABOLITES; GLUTAMATE; GLUTAMINE; MAGNETIC RESONANCE SPECTROSCOPY; SEX;

ADULT; AGING; ASPARTIC ACID; CHOLINE; FEMALE; GLUTAMIC ACID; GLUTAMINE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEUROTRANSMITTER AGENTS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEX FACTORS; YOUNG ADULT;

EID: 84890045109     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.24123     Document Type: Article

References (40)

1. Sonnewald U, Qu H, Aschner M,. Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling. J Pharmacol Exp Ther 2002; 301: 1-6.
2. Hedden T, Gabrieli JD,. Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 2004; 5: 87-96.
3. Boumezbeur F, Mason GF, de Graaf RA, et al. Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cerebral Blood Flow Metab 2010; 30: 211-221.
4. Nedergaard M, Takano T, Hansen AJ,. Beyond the role of glutamate as a neurotransmitter. Nat Rev Neurosci 2002; 3: 748-755.
5. Westall FC, Hawkins A, Ellison GW, Myers LW,. Abnormal glutamic acid metabolism in multiple sclerosis. J Neurol Sci 1980; 47: 353-364.
6. Pioro EP, Majors AW, Mitsumoto H, Nelson DR, Ng TC,. 1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla. Neurology 1999; 53: 71-79.
7. Bliss TV, Collingridge GL,. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361: 31-39.
8. Kirvell SL, Esiri M, Francis PT,. Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease. J Neurochem 2006; 98: 939-950.
9. Segovia G, Porras A, Del Arco A, Mora F,. Glutamatergic neurotransmission in aging: a critical perspective. Mech Ageing Dev 2001; 122: 1-29.
10. Zhang X, Liu H, Wu J, Zhang X, Liu M, Wang Y,. Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats. Neurochem Int 2009; 54: 481-487.
11. Schubert F, Gallinat J, Seifert F, Rinneberg H,. Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla. Neuroimage 2004; 21: 1762-1771.
12. Kaiser LG, Schuff N, Cashdollar N, Weiner MW,. Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T. Neurobiol Aging 2005; 26: 665-672.
13. Zahr NM, Mayer D, Pfefferbaum A, Sullivan EV,. Low striatal glutamate levels underlie cognitive decline in the elderly: evidence from in vivo molecular spectroscopy. Cereb Cortex 2008; 18: 2241-2250.
14. Chang L, Jiang CS, Ernst T, et al. Effects of age and sex on brain glutamate and other metabolites. Magn Reson Imaging 2009; 27: 142-145.
15. Haghighat N,. Estrogen (17beta-estradiol) enhances glutamine synthetase activity in C6-glioma cells. Neurochem Res 2005; 30: 661-667.
16. O'Gorman R, Michels L, Edden RA, Murdoch JB, Martin E., In vivo detection of GABA and glutamate with MEGA-PRESS: reproducibility and gender effects. J Magn Reson Imaging 2011; 33: 1262-1267.
17. Gallinat J, Kunz D, Senkowski D, et al. Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing. Psychopharmacology (Berl) 2006; 187: 103-111.
18. Cotman C, Monaghan D,. Chemistry and anatomy of excitatory amino acid systems. In:, Meltzer HY, editor. Psychopharmacology: the third generation of progress. San Diego: Raven Press; 1987. p 197-210.
19. Kerwin R, Patel S, Meldrum B,. Quantitative autoradiographic analysis of glutamate binding sites in the hippocampal formation in normal and schizophrenic brain post mortem. Neuroscience 1990; 39: 25-32.
20. Maudsley AA, Govind V, Arheart KL,. Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions. NMR Biomed 2012; 25: 580-593.
21. Haga KK, Khor YP, Farrall A, Wardlaw JM,. A systematic review of brain metabolite changes, measured with 1H magnetic resonance spectroscopy, in healthy aging. Neurobiol Aging 2009; 30: 353-563.
22. Elster C, Schubert F, Link A, Walzel M, Seifert F, Rinneberg H,. Quantitative magnetic resonance spectroscopy: semi-parametric modeling and determination of uncertainties. Magn Reson Med 2005; 53: 1288-1296.
23. Danielsen ER, Henriksen O,. Absolute quantitative proton NMR spectroscopy based on the amplitude of the local water suppression pulse. Quantification of brain water and metabolites. NMR Biomed 1994; 7: 311-318.
24. Kirov II, Fleysher L, Fleysher R, Patil V, Liu S, Gonen O,. Age dependence of regional proton metabolites T2 relaxation zimes in the human brain at 3 T. Magn Reson Med 2008; 60: 790-795.
25. Cotman CW, Monaghan DT, Ganong AH,. Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. Annu Rev Neurosci 1988; 11: 61-80.
26. Lin AP, Shic F, Enriquez C, Ross BD,. Reduced glutamate neurotransmission in patients with Alzheimer's disease-an in vivo (13)C magnetic resonance spectroscopy study. MAGMA 2003; 16: 29-42.
27. Zhang F, Zheng W, Pi R, et al. Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. Exp Brain Res 2009; 193: 109-118.
28. Singh M, Dykens JA, Simpkins JW,. Novel mechanisms for estrogen-induced neuroprotection. Exp Biol Med 2006; 231: 514-521.
29. Hafner H,. Gender differences in schizophrenia. Psychoneuroendocrinology 2003; 28 (Suppl 2): 17-54.
30. Hayes E, Gavrilidis E, Kulkarni J,. The role of oestrogen and other hormones in the pathophysiology and treatment of schizophrenia. Schizophr Res Treatment 2012; 2012: 540273.
31. Forster DM, James MF, Williams SR,. Effects of Alzheimer's disease transgenes on neurochemical expression in the mouse brain determined by (1)H MRS in vitro. NMR Biomed 2012; 25: 52-58.
32. Masola B, Ngubane NP,. The activity of phosphate-dependent glutaminase from the rat small intestine is modulated by ADP and is dependent on integrity of mitochondria. Arch Biochem Biophys 2010; 504: 197-203.
33. Wallace DR, Dawson R Jr,. Regional differences in glutaminase activation by phosphate and calcium in rat brain: impairment in aged rats and implications for regional glutaminase isozymes. Neurochem Res 1993; 18: 1271-1279.
34. Clark JF, Doepke A, Filosa JA, et al. N-acetylaspartate as a reservoir for glutamate. Med Hypotheses 2006; 67: 506-512.
35. Kantarci K, Weigand SD, Petersen RC, et al. Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 2007; 28: 1330-1339.
36. Sailasuta N, Ernst T, Chang L,. Regional variations and the effects of age and gender on glutamate concentrations in the human brain. Magn Reson Imaging 2008; 26: 667-675.
37. Rasgon NL, Thomas MA, Guze BH, et al. Menstrual cycle-related brain metabolite changes using 1H magnetic resonance spectroscopy in premenopausal women: a pilot study. Psychiatry Res 2001; 106: 47-57.
38. Bohacek J, Bearl AM, Daniel JM,. Long-term ovarian hormone deprivation alters the ability of subsequent oestradiol replacement to regulate choline acetyltransferase protein levels in the hippocampus and prefrontal cortex of middle-aged rats. J Neuroendocrinol 2008; 20: 1023-1027.
39. Griffith HR, den Hollander JA, Okonkwo OC, O'Brien T, Watts RL, Marson DC,. Brain metabolism differs in Alzheimer's disease and Parkinson's disease dementia. Alzheimers Dement 2008; 4: 421-427.
40. Rasgon NL, Small GW, Siddarth P, et al. Estrogen use and brain metabolic change in older adults. A preliminary report. Psychiatry Res 2001; 107: 11-18.