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Volumn 25, Issue 1, 2012, Pages 52-58

Effects of Alzheimer's disease transgenes on neurochemical expression in the mouse brain determined by 1H MRS in vitro

Author keywords

Alzheimer's disease; MRS; TASTPM mouse

Indexed keywords

AGE DEPENDENCE; ALZHEIMER'S DISEASE; AQUEOUS FRACTIONS; DISEASE PROGRESSION; DRUG DISCOVERY; ENERGY METABOLISM; GLYCEROPHOSPHOCHOLINE; HUMAN DISEASE; IN-VITRO; IN-VIVO; INTERNAL STANDARDS; METABOLITE CONCENTRATIONS; MOUSE BRAIN; MRS; MYO-INOSITOL; N-ACETYLASPARTATE; OSMOTIC STRESS; RESONANCE INTEGRAL; TASTPM MOUSE; TRANS-GENES; TRANSGENIC MODELS; TRANSGENICS; WILD TYPES;

EID: 84855867025     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1712     Document Type: Article
Times cited : (17)

References (37)
  • 1
    • 20444435798 scopus 로고    scopus 로고
    • Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease
    • Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer DP. Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neurosci. Lett. 2005; 384: 23-28.
    • (2005) Neurosci. Lett. , vol.384 , pp. 23-28
    • Ackl, N.1    Ising, M.2    Schreiber, Y.A.3    Atiya, M.4    Sonntag, A.5    Auer, D.P.6
  • 2
    • 37749003347 scopus 로고    scopus 로고
    • Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment
    • Bayer TA, Wirths O. Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairment. Genes Brain Behav. 2008; 7 Suppl 1: 6-11.
    • (2008) Genes Brain Behav. , vol.7 , Issue.SUPPL. 1 , pp. 6-11
    • Bayer, T.A.1    Wirths, O.2
  • 3
    • 40449115788 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model
    • Bayer TA, Breyhan H, Duan K, Rettig J, Wirths O. Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model. Neurodegener. Dis. 2008; 5: 140-142.
    • (2008) Neurodegener. Dis. , vol.5 , pp. 140-142
    • Bayer, T.A.1    Breyhan, H.2    Duan, K.3    Rettig, J.4    Wirths, O.5
  • 4
    • 28544450766 scopus 로고    scopus 로고
    • Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study
    • Beacher F, Simmons A, Daly E et al. Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study. Arch. of gen. psych. 2005; 62: 1360-1365.
    • (2005) Arch. of gen. psych. , vol.62 , pp. 1360-1365
    • Beacher, F.1    Simmons, A.2    Daly, E.3
  • 5
    • 0027397544 scopus 로고
    • Inositol trisphosphate and calcium signalling
    • Berridge MJ. Inositol trisphosphate and calcium signalling. Nature 1993; 361: 315-325.
    • (1993) Nature , vol.361 , pp. 315-325
    • Berridge, M.J.1
  • 7
    • 0027749707 scopus 로고
    • Multinuclear NMR studies on the energy metabolism of glial and neuronal cells
    • Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev. Neurosci. 1993; 15: 289-298.
    • (1993) Dev. Neurosci. , vol.15 , pp. 289-298
    • Brand, A.1    Richter-Landsberg, C.2    Leibfritz, D.3
  • 8
    • 2442582930 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
    • Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004; 1012: 60-65.
    • (2004) Brain Res. , vol.1012 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 9
    • 0036787479 scopus 로고    scopus 로고
    • Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease
    • Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's disease. Brain 2002; 125: 2332-2341.
    • (2002) Brain , vol.125 , pp. 2332-2341
    • Dixon, R.M.1    Bradley, K.M.2    Budge, M.M.3    Styles, P.4    Smith, A.D.5
  • 10
    • 0042736668 scopus 로고    scopus 로고
    • Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study
    • Drzezga A, Lautenschlager N, Siebner H et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study. Eur. J. Nucl. Med. Mol. Imaging. 2003; 30: 1104-1113.
    • (2003) Eur. J. Nucl. Med. Mol. Imaging. , vol.30 , pp. 1104-1113
    • Drzezga, A.1    Lautenschlager, N.2    Siebner, H.3
  • 11
    • 0030915132 scopus 로고    scopus 로고
    • Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy
    • Ernst T, Chang L, Melchor R, Mehringer CM. Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. Radiology 1997; 203: 829-836.
    • (1997) Radiology , vol.203 , pp. 829-836
    • Ernst, T.1    Chang, L.2    Melchor, R.3    Mehringer, C.M.4
  • 12
    • 0036895396 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy and cognitive function in healthy elderly men
    • Ferguson KJ, MacLullich AM, Marshall I et al. Magnetic resonance spectroscopy and cognitive function in healthy elderly men. Brain 2002; 125: 2743-2749.
    • (2002) Brain , vol.125 , pp. 2743-2749
    • Ferguson, K.J.1    MacLullich, A.M.2    Marshall, I.3
  • 15
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-356.
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 16
    • 3142668938 scopus 로고    scopus 로고
    • Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
    • Howlett DR, Richardson JC, Austin A et al. Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes. Brain Res. 2004; 1017: 130-136.
    • (2004) Brain Res. , vol.1017 , pp. 130-136
    • Howlett, D.R.1    Richardson, J.C.2    Austin, A.3
  • 17
    • 35748982126 scopus 로고    scopus 로고
    • Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease
    • Howlett DR, Bowler K, Soden PE et al. Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease. Histol. Histopathol. 2008; 23: 67-76.
    • (2008) Histol. Histopathol. , vol.23 , pp. 67-76
    • Howlett, D.R.1    Bowler, K.2    Soden, P.E.3
  • 18
    • 0035964302 scopus 로고    scopus 로고
    • Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study
    • Huang W, Alexander GE, Chang L et al. Brain metabolite concentration and dementia severity in Alzheimer's disease: a (1)H MRS study. Neurology 2001; 57: 626-632.
    • (2001) Neurology , vol.57 , pp. 626-632
    • Huang, W.1    Alexander, G.E.2    Chang, L.3
  • 19
    • 0033811153 scopus 로고    scopus 로고
    • Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    • Jessen F, Block W, Traber F et al. Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD. Neurology 2000; 55: 684-688.
    • (2000) Neurology , vol.55 , pp. 684-688
    • Jessen, F.1    Block, W.2    Traber, F.3
  • 20
    • 0036827038 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease
    • Kantarci K, Smith GE, Ivnik RJ et al. 1H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease. J. Int. Neuropsychol. Soc. 2002; 8: 934-942.
    • (2002) J. Int. Neuropsychol. Soc. , vol.8 , pp. 934-942
    • Kantarci, K.1    Smith, G.E.2    Ivnik, R.J.3
  • 21
    • 7044220330 scopus 로고    scopus 로고
    • 1H MR spectroscopy in common dementias
    • Kantarci K, Petersen RC, Boeve BF et al. 1H MR spectroscopy in common dementias. Neurology 2004; 63: 1393-1398.
    • (2004) Neurology , vol.63 , pp. 1393-1398
    • Kantarci, K.1    Petersen, R.C.2    Boeve, B.F.3
  • 23
  • 24
    • 0036182507 scopus 로고    scopus 로고
    • A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy
    • Le Belle JE, Harris NG, Williams SR, Bhakoo KK. A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed. 2002; 15: 37-44.
    • (2002) NMR Biomed. , vol.15 , pp. 37-44
    • Le Belle, J.E.1    Harris, N.G.2    Williams, S.R.3    Bhakoo, K.K.4
  • 25
    • 0025367229 scopus 로고
    • Effects of hypernatremia on organic brain osmoles
    • Lien YH, Shapiro JI, Chan L. Effects of hypernatremia on organic brain osmoles. J. Clin. Invest. 1990; 85: 1427-1435.
    • (1990) J. Clin. Invest. , vol.85 , pp. 1427-1435
    • Lien, Y.H.1    Shapiro, J.I.2    Chan, L.3
  • 26
    • 67349251602 scopus 로고    scopus 로고
    • Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI
    • Maheswaran S, Barjat H, Rueckert D et al. Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI. Brain Res. 2009; 1270: 19-32.
    • (2009) Brain Res. , vol.1270 , pp. 19-32
    • Maheswaran, S.1    Barjat, H.2    Rueckert, D.3
  • 27
    • 23844505632 scopus 로고    scopus 로고
    • Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy
    • Marjanska M, Curran GL, Wengenack TM et al. Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. Proc. Natl. Acad. Sci. U S A. 2005; 102: 11906-11910.
    • (2005) Proc. Natl. Acad. Sci. U S A. , vol.102 , pp. 11906-11910
    • Marjanska, M.1    Curran, G.L.2    Wengenack, T.M.3
  • 28
    • 0033525520 scopus 로고    scopus 로고
    • Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
    • Moechars D, Dewachter I, Lorent K et al. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J. Biol. Chem. 1999; 274: 6483-6492.
    • (1999) J. Biol. Chem. , vol.274 , pp. 6483-6492
    • Moechars, D.1    Dewachter, I.2    Lorent, K.3
  • 29
    • 34249881080 scopus 로고    scopus 로고
    • Autophagocytosis of mitochondria is prominent in Alzheimer disease
    • Moreira PI, Siedlak SL, Wang X et al. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathol. Exp. Neurol. 2007); 66: 525-532.
    • (2007) J. Neuropathol. Exp. Neurol. , vol.66 , pp. 525-532
    • Moreira, P.I.1    Siedlak, S.L.2    Wang, X.3
  • 30
    • 0032587972 scopus 로고    scopus 로고
    • A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression
    • Rose SE, de Zubicaray GI, Wang D et al. A 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. Magn. Reson. Imaging. 1999; 17: 291-299.
    • (1999) Magn. Reson. Imaging. , vol.17 , pp. 291-299
    • Rose, S.E.1    de Zubicaray, G.I.2    Wang, D.3
  • 31
    • 77953124257 scopus 로고    scopus 로고
    • A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease
    • Salek RM, Xia J, Innes A et al. A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochem. intnl. 2010; 56: 937-947.
    • (2010) Neurochem. intnl. , vol.56 , pp. 937-947
    • Salek, R.M.1    Xia, J.2    Innes, A.3
  • 32
    • 0028932753 scopus 로고
    • Probable Alzheimer disease: diagnosis with proton MR spectroscopy
    • Shonk TK, Moats RA, Gifford P et al. Probable Alzheimer disease: diagnosis with proton MR spectroscopy. Radiology 1995; 195: 65-72.
    • (1995) Radiology , vol.195 , pp. 65-72
    • Shonk, T.K.1    Moats, R.A.2    Gifford, P.3
  • 33
    • 0026633564 scopus 로고
    • Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro
    • Urenjak J, Williams SR, Gadian DG, Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J. Neurochem. 1992; 59: 55-61.
    • (1992) J. Neurochem. , vol.59 , pp. 55-61
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 34
    • 0027450301 scopus 로고
    • Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types
    • Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J. Neurosci. 1993; 13: 981-989.
    • (1993) J. Neurosci. , vol.13 , pp. 981-989
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 35
    • 0035399655 scopus 로고    scopus 로고
    • Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration
    • Valla J, Berndt JD, Gonzalez-Lima F. Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration. J. Neurosci. 2001; 21: 4923-4930.
    • (2001) J. Neurosci. , vol.21 , pp. 4923-4930
    • Valla, J.1    Berndt, J.D.2    Gonzalez-Lima, F.3
  • 36
    • 11844258289 scopus 로고    scopus 로고
    • Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span
    • von Kienlin M, Kunnecke B, Metzger F et al. Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span. Neurobiol. Dis. 2005; 18: 32-39.
    • (2005) Neurobiol. Dis. , vol.18 , pp. 32-39
    • von Kienlin, M.1    Kunnecke, B.2    Metzger, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.