The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation

Biochemical Journal

Volumn 457, Issue 1, 2014, Pages 171-183

  Lu, Xin An ^a   Wang, Xiaofeng ^a   Zhuo, Wei ^a   Jia, Lin ^a   Jiang, Yushan ^a   Fu, Yan ^a   Luo, Yongzhang ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

(Hsp90 ); Client; Heat shock protein 90 ; Phosphorylation switch; Protein kinase C (PKC ); Threonine residue set

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CASPASE 3; CELL CYCLE PROTEIN 37; CHAPERONE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 ALPHA; PROTEIN KINASE C GAMMA; THREONINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CELL MIGRATION; CELL SURVIVAL; CONFORMATIONAL TRANSITION; CYTOSOL; CYTOSOLIC FRACTION; DIMERIZATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REGULATORY MECHANISM; WESTERN BLOTTING;

APOPTOSIS; CELL CYCLE PROTEINS; CELL MOVEMENT; CHAPERONINS; ENZYME ACTIVATION; HCT116 CELLS; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 84890029528     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130963     Document Type: Article

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