Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells

Journal of Gastroenterology

Volumn 48, Issue 11, 2013, Pages 1222-1233

  Kajita, Keisuke ^a   Kuwano, Yuki ^a   Kitamura, Naruka ^a,b   Satake, Yuzuru ^a   Nishida, Kensei ^a   Kurokawa, Ken ^a   Akaike, Yoko ^a   Honda, Manami ^a   Masuda, Kiyoshi ^a   Rokutan, Kazuhito ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Colon cancer; Ets1; Heat shock factor 1; Oxidative stress; Transformer 2

Indexed keywords

ARSENIC TRIOXIDE; HEAT SHOCK TRANSCRIPTION FACTOR 1; MESSENGER RNA; SERINE ARGININE RICH PROTEIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR NRF2; TRANSFORMER 2 BETA PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; COLON ADENOCARCINOMA; COLON CANCER; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA FLANKING REGION; EXON; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; OXIDATIVE STRESS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA STABILITY; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; TRANSFORMER 2 BETA GENE; TUMOR GENE; UPREGULATION;

ADENOCARCINOMA; APOPTOSIS; ARSENITES; BASE SEQUENCE; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HEAT-SHOCK RESPONSE; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEIN C-ETS-1; RNA, MESSENGER; RNA, NEOPLASM; RNA-BINDING PROTEINS; SODIUM COMPOUNDS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 84889888934     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0745-2     Document Type: Article

References (42)

1. Matsuo N, Ogawa S, Imai Y, et al. Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation. J Biol Chem. 1995;270:28216-22.
2. Beil B, Screaton G, Stamm S. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. DNA Cell Biol. 1997;16:679-90.
3. Tacke R, Tohyama M, Ogawa S, et al. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell. 1998;93:139-48.
4. Hertel KJ, Maniatis T. The function of multisite splicing enhancers. Mol Cell. 1998;1:449-55.
5. Qi J, Su S, McGuffin ME, et al. Concentration dependent selection of targets by an SR splicing regulator results in tissue-specific RNA processing. Nucleic Acids Res. 2006;34:6256-63.
6. Nayler O, Cap C, Stamm S. Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform. Genomics. 1998;53:191-202.
7. Hofmann Y, Lorson CL, Stamm S, et al. Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2). Proc Natl Acad Sci USA. 2000;97:9618-23.
8. Singh NN, Androphy EJ, Singh RN. In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes. RNA. 2004;10:1291-305.
9. Martins de Araujo M, Bonnal S, Hastings ML, et al. Differential 3′ splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP. RNA 2009;15:515-23.
10. Jiang Z, Tang H, Havlioglu N, et al. Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J Biol Chem. 2003;278:18997-9007.
11. Kondo S, Yamamoto N, Murakami T, et al. Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. Genes Cells. 2004;9:121-30.
12. Watermann DO, Tang Y, Zur Hausen A, et al. Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene. Cancer Res. 2006;66:4774-80.
13. Tsukamoto Y, Matsuo N, Ozawa K, et al. Expression of a novel RNA-splicing factor, RA301/Tra2beta, in vascular lesions and its role in smooth muscle cell proliferation. Am J Pathol. 2001;158:1685-94.
14. Kiryu-Seo S, Matsuo N, Wanaka A, et al. A sequence-specific splicing activator, tra2beta, is up-regulated in response to nerve injury. Brain Res Mol Brain Res. 1998;62:220-3.
15. Gabriel B, Zur Hausen A, Bouda J, et al. Significance of nuclear hTra2-beta1 expression in cervical cancer. Acta Obstet Gynecol Scand. 2009;88:216-21.
16. Fischer DC, Noack K, Runnebaum IB, et al. Expression of splicing factors in human ovarian cancer. Oncol Rep. 2004;11:1085-90.
17. Takeo K, Kawai T, Nishida K, et al. Oxidative stress-induced alternative splicing of transformer 2beta (SFRS10) and CD44 pre-mRNAs in gastric epithelial cells. Am J Physiol Cell Physiol. 2009;297:C330-8.
18. Daoud R, Da Penha Berzaghi M, Siedler F, et al. Activity-dependent regulation of alternative splicing patterns in the rat brain. Eur J Neurosci. 1999;11:788-802.
19. Nakayama T, Ito M, Ohtsuru A, et al. Expression of the ets-1 proto-oncogene in human colorectal carcinoma. Mod Pathol. 2001;14:415-22.
20. Stoilov P, Daoud R, Nayler O, et al. Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA. Hum Mol Genet. 2004;13:509-24.
21. Wang ET, Sandberg R, Luo S, et al. Alternative isoform regulation in human tissue transcriptomes. Nature. 2008;456:470-6.
22. Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478:64-9.
23. Rockenstein EM, McConlogue L, Tan H, et al. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem. 1995;270:28257-67.
24. Fugier C, Klein AF, Hammer C, et al. Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy. Nat Med. 2011;17:720-5.
25. Venables JP, Klinck R, Koh C, et al. Cancer-associated regulation of alternative splicing. Nat Struct Mol Biol. 2009;16:670-6.
26. Meira LB, Bugni JM, Green SL, et al. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J Clin Invest. 2008;118:2516-25.
27. Ozaki M, Deshpande SS, Angkeow P, et al. Rac1 regulates stress-induced, redox-dependent heat shock factor activation. J Biol Chem. 2000;275:35377-83.
28. Jacobs AT, Marnett LJ. Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL. J Biol Chem. 2007;282:33412-20.
29. Vilaboa NE, Galan A, Troyano A, et al. Regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1). J Biol Chem. 2000;275:24970-6.
30. Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol. 2001;2:827-37.
31. Oikawa T, Yamada T. Molecular biology of the Ets family of transcription factors. Gene. 2003;303:11-34.
32. Hsu T, Trojanowska M, Watson DK. Ets proteins in biological control and cancer. J Cell Biochem. 2004;91:896-903.
33. Singh AK, Swarnalatha M, Kumar V. c-ETS1 facilitates G1/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation. J Biol Chem. 2011;286:21961-70.
34. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. 2005;41:2462-78.
35. Ito Y, Takeda T, Okada M, et al. Expression of ets-1 and ets-2 in colonic neoplasms. Anticancer Res. 2002;22:1581-4.
36. Foulds CE, Nelson ML, Blaszczak AG, et al. Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment. Mol Cell Biol. 2004;24:10954-64.
37. Wilson LA, Gemin A, Espiritu R, et al. ets-1 is transcriptionally up-regulated by H2O2 via an antioxidant response element. FASEB J. 2005;19:2085-7.
38. Venables JP, Bourgeois CF, Dalgliesh C, et al. Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. Hum Mol Genet. 2005;14:2289-303.
39. Rochat-Steiner V, Becker K, Micheau O, et al. FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation. J Exp Med. 2000;192:1165-74.
40. Novoyatleva T, Heinrich B, Tang Y, et al. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum Mol Genet. 2008;17:52-70.
41. Benderska N, Becker K, Girault JA, et al. DARPP-32 binds to tra2-beta1 and influences alternative splicing. Biochim Biophys Acta. 2010;1799:448-53.
42. Shi Y, Manley JL. A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. Mol Cell. 2007;28:79-90. Technology Technology Technology