A sequence-specific splicing activator, Tra2β, is up-regulated in response to nerve injury

Molecular Brain Research

Volumn 62, Issue 2, 1998, Pages 220-223

  Kiryu Seo, Sumiko ^a   Matsuo, Noriyuki ^b   Wanaka, Akio ^c   Ogawa, Satoshi ^d   Tohyama, Masaya ^d   Kiyama, Hiroshi ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b Licensing Division   (Japan)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Brain damage; Nerve regeneration; RNA splicing; Tra2

Indexed keywords

RNA BINDING PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYPOGLOSSAL NERVE; MALE; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; RNA SPLICING;

ANIMALS; AXOTOMY; DOMINANCE, CEREBRAL; GENE EXPRESSION REGULATION; HYPOGLOSSAL NERVE; MALE; MEDULLA OBLONGATA; MOTOR NEURONS; NERVE REGENERATION; NERVE TISSUE PROTEINS; RATS; RATS, WISTAR; RNA SPLICING; RNA-BINDING PROTEINS; TEMPORAL LOBE;

EID: 0032569991     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00255-1     Document Type: Article

References (25)

1. Arriza J.L., Fairman W.A., Wadiche J.I., Murdich G.H., Kavanaugh M.P., Amara S.G. Functional comparison of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14:1994;5559-5569.
2. Beil B., Screaton G., Stamm S. Molecular cloning of htra2β-1 and htra2β-2, two human homologs of tra-2 generated by alternative splicing. DNA Cell Biol. 16:1997;679-690.
3. Chambers C.B., Muma N.A. Tau mRNA isoforms following sciatic nerve axotomy with and without regeneration. Mol. Brain Res. 45:1997;115-124.
4. Dauwalder B., Amaya-Manzanares F., Mattox W. A human homolog of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. Proc. Natl. Acad. Sci. USA. 93:1996;9004-9009.
5. Fischer U., Liu Q., Dreyfuss G. The SMN-SIP1 complex has an essential role in splicesomal snRNP biogenesis. Cell. 90:1997;1023-1029.
6. Fu X.D. The superfamily of arginine/serine-rich splicing factors. RNA. 1:1995;663-680.
7. Haas C.A., Donath C., Kreutzberg G.W. Differential expression of immediate early genes after transection of the facial nerve. Neuroscience. 53:1993;91-99.
8. Herdegen T., Bastmeyer M., Bahr M., Stuermer C., Bravo R., Zimmermann M. Expression of JUN, KROX, and CREB transcription factors in goldfish and rat retinal ganglion cells following optic nerve lesion is related to axonal sprouting. J. Neurobiol. 24:1993;528-543.
9. Hirota H., Kiyama H., Kishimoto T., Taga T. Accelerated nerve regeneration in mice by upregulated expression of IL6 and IL6-receptor after trauma. J. Exp. Med. 183:1996;2627-2634.
10. Hoshijima K., Inoue K., Higuchi I., Sakamoto H., Shimura Y. Control of double-sex alternative splicing by transformer and transformer-2 in Drosophila. Science. 252:1991;833-836.
11. Imai Y., Matsuo N., Ogawa S., Tohyama M., Takagi T. Cloning of a gene YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. Mol. Brain Res. 53:1998;33-40.
12. Kiryu S., Yao G.L., Morita N., Kato H., Kiyama H. Nerve injury enhances rat neuronal glutamate transporter expression: identification by differential display PCR. J. Neurosci. 15:1995;7872-7878.
13. Lin C.-L.G., Bristol L.A., Jin L., Dykes-Hoberg M., Crawford T., Clawson L., Rothstein J.D. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron. 20:1998;589-602.
14. Liu Q., Fischer U., Wang F., Dreyfuss G. The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with splicesomal snRNP proteins. Cell. 90:1997;1013-1021.
15. Maeda Y., Matsumoto M., Hori O., Kuwabara K., Ogawa S., Yan S.D., Ohtsuki T., Kinoshita T., Kamada T., Stern D.M. Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: a paracrine mechanism potentially enhancing neuron survival. J. Exp. Med. 180:1994;2297-2308.
16. Manley J.L., Tacke R. SR proteins and splicing control. Genes Dev. 10:1996;1569-1579.
17. Matsuo N., Ogawa S., Imai Y., Takagi T., Tohyama M., Stern D., Wanaka A. Cloning of a novel RNA binding polypeptide (RA301) induced by hypopxia/reoxygenation. J. Biol. Chem. 270:1995;28216-28222.
18. Mattox W., Palmer M.J., Baker B.S. Alternative splicing of the sex determination gene transformer-2 is sex-specific in the germ line but not in the soma. Genes Dev. 4:1990;789-805.
19. Namikawa K., Su Q., Kiryu-Seo S., Kiyama H. Enhanced expression of 14-3-3 family members in injured motoneurons. Mol. Brain Res. 55:1998;315-320.
20. Segade F., Hurlé B., Claudio E., Ramos S., Lazo P.S. Molecular cloning of a mouse homologue for the Drosophila splicing regulator Tra2. FEBS Lett. 387:1996;152-156.
21. Su Q., Namikawa K., Toki H., Kiyama H. Differential dispaly reveals transcriptional up-regulation of the motor molecules for both anterograde and retrograde axonal transport during nerve regeneration. Eur. J. Neurosci. 9:1997;1542-1547.
22. Tacke R., Tohyama M., Ogawa S., Manley J.L. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell. 93:1998;39-148.
23. Tanabe K., Kiryu-Seo S., Nakamura T., Mori N., Tsujino H., Ochi T., Kiyama H. Alternative expression of Shc family members in nerve-injured motoneurons. Mol. Brain Res. 53:1998;291-296.
24. Toki H., Namikawa K., Su Q., Kiryu-Seo S., Sato K., Kiyama H. Enhancement of extracellular glutamate scavenge system in injured motoneurons. J. Neurochem. 71:1998;913-919.
25. Yao G.L., Kato H., Khalil M., Kiryu S., Kiyama H. Selective upregulation of cytokine receptor subchain and their intracellular signalling molecules after peripheral nerve injury. Eur. J. Neurosci. 9:1997;1047-1054.