Enhanced bone regeneration of cortical segmental bone defects using porous titanium scaffolds incorporated with colloidal gelatin gels for time-and dose-controlled delivery of dual growth factors

Tissue Engineering - Part A

Volumn 19, Issue 23-24, 2013, Pages 2605-2614

  Van Der Stok, Johan ^a   Wang, Huanan ^b   Amin Yavari, Saber ^c   Siebelt, Michiel ^a   Sandker, Marjan ^a   Waarsing, Jan H ^a   Verhaar, Jan A N ^a   Jahr, Holger ^a   Zadpoor, Amir A ^c   Leeuwenburgh, Sander C G ^b   Weinans, Harrie ^a,c,d  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MATERIALS; BONE; COMPUTERIZED TOMOGRAPHY; CROSSLINKING; DEFECTS; GELS; GRAFTING (CHEMICAL); TISSUE REGENERATION; TITANIUM;

BONE MORPHOGENETIC PROTEIN-2; CROSS-LINKING DENSITY; FIBROBLAST GROWTH FACTOR-2; MECHANICAL SUPPORT; POROUS STRUCTURES; SEGMENTAL BONE DEFECT; STIMULATORY EFFECTS; THREE-POINT BENDING TEST;

SCAFFOLDS (BIOLOGY);

FIBROBLAST GROWTH FACTOR 2; GELATIN; NANOSPHERE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DEFECT; BONE IMPLANT; BONE MASS; BONE REGENERATION; CONTROLLED STUDY; CROSS LINKING; EX VIVO STUDY; FEMUR; GEL; IN VIVO STUDY; MALE; NONHUMAN; OSSIFICATION; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; ZETA POTENTIAL;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; DRUG DELIVERY SYSTEMS; FIBROBLAST GROWTH FACTOR 2; HYDROGEL; MALE; NANOSTRUCTURES; RATS; RATS, WISTAR; TISSUE SCAFFOLDS; TITANIUM;

EID: 84889801229     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2013.0181     Document Type: Article

References (32)

1. Langer, R., and Vacanti, J.P. Tissue engineering. Science 260, 920, 1993.
2. Van der Stok, J., Van Lieshout, E.M.M., El-Massoudi, Y., Van Kralingen, G.H., and Patka, P. Bone substitutes in the Netherlands-a systematic literature review. Acta Biomater 7, 739, 2011.
3. Cypher, T.J., and Grossman, J.P. Biological principles of bone graft healing. J Foot Ankle Surg 35, 413, 1996.
4. Banwart, J.C., Asher, M.A., and Hassanein, R.S. Iliac crest bone graft harvest donor site morbidity. A statistical evaluation. Spine 20, 1055, 1995.
5. Albrektsson, T., and Johansson, C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J 10 Suppl 2, S96, 2001.
6. Van der Stok, J., Van der Jagt, O.P., Amin Yavari, S., De Haas, M.F.P., Waarsing, J.H., Jahr, H., et al. Selective laser melting produced porous titanium scaffolds regenerate bone in critical size cortical bone defects J Orthop Res 31, 792, 2013.
7. Schmid, G.J., Kobayashi, C., Sandell, L.J., and Ornitz, D.M. Fibroblast growth factor expression during skeletal fracture healing in mice. Dev Dyn 238, 766, 2009.
8. Carano, R.A.D., and Filvaroff, E.H. Angiogenesis and bone repair. Drug Discov Today 8, 980, 2003.
9. Gerstenfeld, L.C., and Einhorn, T.A. Developmental aspects of fracture healing and the use of pharmacological agents to alter healing. J Musculoskelet Neuronal Interact 3, 297, 2003.
10. Chen, F.M., Zhang, M., and Wu, Z.F. Toward delivery of multiple growth factors in tissue engineering. Biomaterials 31, 6279, 2010.
11. Carragee, E.J., Hurwitz, E.L., and Weiner, B.K. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J 11, 471, 2011.
12. Bradley, M., Lazim, A.M., and Eastoe, J. Stimulus-responsive heteroaggregation of colloidal dispersions: reversible systems and composite materials. Polymers 3, 1036, 2011.
13. Wang, H., Leeuwenburgh, S.C.G., Li, Y., and Jansen, J.A. The use of micro-and nanospheres as functional components for bone tissue regeneration. Tissue Eng Part B Rev 18, 24, 2012.
14. Wang, H., Zou, Q., Boerman, O., C, Nijhuis, A.W., Jansen, J.A., Li, Y., et al. Combined delivery of BMP-2 and bFGF from nanostructured colloidal gelatin gels and its effect on bone regeneration in vivo. J Control Release 166, 172, 2013.
15. Fujimura, K., Bessho, K., Okubo, Y., Kusumoto, K., Segami, N., and Iizuka, T. The effect of fibroblast growth factor-2 on the osteoinductive activity of recombinant human bone morphogenetic protein-2 in rat muscle. Arch Oral Biol 47, 577, 2002.
16. Springer, I.N.G., Niehoff, P., Açil, Y., Marget, M., Lange, A., Warnke, P.H., Pielenz, H., Roldán, J.C., and Wiltfang, J. BMP-2 and bFGF in an irradiated bone model. J Craniomaxillofacial Surg 36, 210, 2008.
17. Wang, H., Hansen, M.B., Lowik, D.W., van Hest, J.C., Li, Y., Jansen, J.A., et al. Oppositely charged gelatin nanospheres as building blocks for injectable and biodegradable gels. Adv Mater 23, H119, 2011.
18. Takemoto, M., Fujibayashi, S., Neo, M., Suzuki, J., Matsushita, T., Kokubo, T., et al. Osteoinductive porous titanium implants: effect of sodium removal by dilute HCl treatment. Biomaterials 27, 2682, 2006.
19. Unger, S., Blauth, M., and Schmoelz, W. Effects of three different preservation methods on the mechanical properties of human and bovine cortical bone. Bone 47, 1048, 2010.
20. Murr, L.E., Gaytan, S.M., Medina, F., Lopez, H., Martinez, E., Machado, B.I., et al. Next-generation biomedical implants using additive manufacturing of complex, cellular and functional mesh arrays. Philos Transact A Math Phys Eng Sci 368, 1999.
21. Marsell, R., and Einhorn, T.A. The biology of fracture healing. Injury 42, 551, 2011.
22. Zara, J.N., Siu, R.K., Zhang, X., Shen, J., Ngo, R., Lee, M., et al. High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. Tissue Eng Part A 17, 1389.
23. Angle, S.R., Sena, K., Sumner, D.R., Virkus, W.W., and Virdi, A.S. Healing of rat femoral segmental defect with bone morphogenetic protein-2: a dose response study. J Musculoskelet Neuronal Interact 12, 28, 2012.
24. Zellin, G., and Linde, A. Effects of recombinant human fibroblast growth factor-2 on osteogenic cell populations during orthopic osteogenesis in vivo. Bone 26, 161, 2000.
25. Guillame-Gentil, O., Semenov, O., Roca, A.S., Groth, T., Zahn, R., Vö rö s, J., and Zenobi-Wong, M. Engineering the Extracellular Environment: Strategies for Building 2D and 3D Cellular Structures. Adv Mater 22, 5443, 2010.
26. Luong, L.N., Ramaswamy, J., and Kohn, D.H. Effects of osteogenic growth factors on bone marrow stromal cell differentiation in a mineral-based delivery system. Biomaterials 33, 283, 2012.
27. Tabata, Y., and Ikada, Y. Vascularization effect of basic fibroblast growth factor released from gelatin hydrogels with different biodegradabilities. Biomaterials 20, 2169, 1999.
28. Mayahara, H., Ito, T., Nagai, H., Miyajima, H., Tsukuda, R., Taketomi, S., et al. In vivo stimulation of endosteal bone formation by basic fibroblast growth factor in rats. Growth Factors 9, 73, 1993.
29. Nakamura, Y., Tensho, K., Nakaya, H., Nawata, M., Okabe, T., and Wakitani, S. Low dose fibroblast growth factor-2 (FGF-2) enhances bone morphogenetic protein-2 (BMP-2)-induced ectopic bone formation in mice. Bone 36, 399, 2005.
30. Takita, H., Tsuruga, E., Ono, I., and Kuboki, Y. Enhancement by bFGF of osteogenesis induced by rhBMP-2 in rats. Eur J Oral Sci 105, 588, 1997.
31. Maegawa, N., Kawamura, K., Hirose, M., Yajima, H., Takakura, Y., and Ohgushi, H. Enhancement of osteoblastic differentiation of mesenchymal stromal cells cultured by selective combination of bone morphogenetic protein-2 (BMP-2) and fibroblast growth factor-2 (FGF-2). J Tissue Eng Regen Med 1, 306, 2007.
32. Tanaka, E., Ishino, Y., Sasaki, A., Hasegawa, T., Watanabe, M., Dalla-Bona, D., Yamano, E., van Eijden, T., and Tanne, K. Fibroblast Growth Factor-2 Augments Recombinant Human Bone Morphogenetic Protein-2-Induced Osteoinductive Activity. Ann Biomed Eng 34, 717, 2006.