Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis

Food and Chemical Toxicology

Volumn 63, Issue , 2014, Pages 221-232

  Sun, Xiao ^a   Chen, Rong chang ^a   Yang, Zhi hong ^a   Sun, Gui bo ^a   Wang, Min ^a   Ma, Xiao jun ^a   Yang, Li juan ^b   Sun, Xiao bo ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b BEIHUA UNIVERSITY   (China)

Author keywords

Apoptosis; Diabetic cardiomyopathy; NADPH oxidase; Oxidative stress; Taxifolin

Indexed keywords

ANGIOTENSIN II; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 9; CATALASE; CREATINE KINASE MB; CYTOCHROME C; GLUCOSE; GLUTATHIONE PEROXIDASE; JANUS KINASE; LACTATE DEHYDROGENASE; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STAT3 PROTEIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TAXIFOLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRAIN H9C2; CONTROLLED STUDY; CYTOPLASM; DIABETIC CARDIOMYOPATHY; DIASTOLIC DYSFUNCTION; DRUG EFFECT; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; HEART FUNCTION; HEART MUSCLE CELL; HEART PROTECTION; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; M MODE ECHOCARDIOGRAPHY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MYOBLAST; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; WESTERN BLOTTING;

MUS;

ANG II; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR 1; APOPTOSIS; ASPARTATE AMINOTRANSFERASE; AST; AT1; CAT; CATALASE; CK-MB; CREATININE KINASE-MB ISOENZYME; DCM; DIABETIC CARDIOMYOPATHY; EF; EJECTION FRACTION; FRACTIONAL SHORTENING; FS; GLUTATHIONE PEROXIDASE; GSH-PX; LACTATE DEHYDROGENASE; LDH; LV END-DIASTOLIC VOLUME; LV END-SYSTOLIC VOLUME; LVVD; LVVS; MALONDIALDEHYDE; MDA; MITOCHONDRIAL MEMBRANE POTENTIAL; NADPH OXIDASE; OXIDATIVE STRESS; RAS; REACTIVE OXYGEN SPECIES; RENNIN-ANGIOTENSIN SYSTEM; ROS; SOD; STREPTOZOTOCIN; STZ; SUPEROXIDE DISMUTASE; TAXIFOLIN; ΔΨ(M);

ANGIOTENSIN II; ANIMALS; APOPTOSIS; CASPASES; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; OXIDATIVE STRESS; QUERCETIN; RATS; REACTIVE OXYGEN SPECIES; STREPTOZOCIN;

EID: 84889685687     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.11.013     Document Type: Article

References (33)

1. Aronson D. Hyperglycemia and the pathobiology of diabetic complications. Adv. Cardiol. 2008, 45:1-16.
2. Asghar O., Al-Sunni A., Khavandi K., Khavandi A., Withers S., Greenstein A., Heagerty A.M., Malik R.A. Diabetic cardiomyopathy. Clin. Sci. (Lond) 2009, 116:741-760.
3. Cai L., Li W., Wang G., Guo L., Jiang Y., Kang Y.J. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 2002, 51:1938-1948.
4. Connelly K.A., Boyle A.J., Kelly D.J. Angiotensin II and the cardiac complications of diabetes mellitus. Curr. Pharm. Des. 2007, 13:2721-2729.
5. Dahab G.M., Kheriza M.M., El-Beltagi H.M., Fouda A.M., El-Din O.A. Digital quantification of fibrosis in liver biopsy sections: description of a new method by Photoshop software. J. Gastroenterol. Hepatol. 2004, 19:78-85.
6. Ebrahimi F., Shafaroodi H., Asadi S., Nezami B.G., Ghasemi M., Rahimpour S., Hashemi M., Doostar Y., Dehpour A.R. Sildenafil decreased cardiac cell apoptosis in diabetic mice: reduction of oxidative stress as a possible mechanism. Can. J. Physiol. Pharmacol. 2009, 87:556-564.
7. Fiordaliso F., Li B., Latini R., Sonnenblick E.H., Anversa P., Leri A., Kajstura J. Myocyte death in streptozotocin-induced diabetes in rats in angiotensin II-dependent. Lab Invest. 2000, 80:513-527.
8. Frustaci A., Kajstura J., Chimenti C., Jakoniuk I., Leri A., Maseri A., Nadal-Ginard B., Anversa P. Myocardial cell death in human diabetes. Circ. Res. 2000, 87:1123-1132.
9. Gao X., Xu Y., Xu B., Liu Y., Cai J., Liu H.M., Lei S., Zhong Y.Q., Irwin M.G., Xia Z. Allopurinol attenuates left ventricular dysfunction in rats with early stages of streptozotocin-induced diabetes. Diabetes Metab. Res. Rev. 2012, 28:409-417.
10. Haraguchi H., Ohmi I., Fukuda A., Tamura Y., Mizutani K., Tanaka O., Chou W.H. Inhibition of aldose reductase and sorbitol accumulation by astilbin and taxifolin dihydroflavonols in Engelhardtia chrysolepis. Biosci. Biotechnol. Biochem. 1997, 61:651-654.
11. Heymes C., Bendall J.K., Ratajczak P., Cave A.C., Samuel J.L., Hasenfuss G., Shah A.M. Increased myocardial NADPH oxidase activity in human heart failure. J. Am. Coll. Cardiol. 2003, 41:2164-2171.
12. Kaul N., Siveski-Iliskovic N., Hill M., Khaper N., Seneviratne C., Singal P.K. Probucol treatment reverses antioxidant and functional deficit in diabetic cardiomyopathy. Mol. Cell. Biochem. 1996, 160-161:283-288.
13. Kaul N., Siveski-Iliskovic N., Thomas T.P., Hill M., Khaper N., Singal P.K. Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy. Nutrition 1995, 11:551-554.
14. Khullar M., Al-Shudiefat A.A., Ludke A., Binepal G., Singal P.K. Oxidative stress: a key contributor to diabetic cardiomyopathy. Can. J. Physiol. Pharmacol. 2010, 88:233-240.
15. Kumar S., Kain V., Sitasawad S.L. High glucose-induced Ca(2+) overload and oxidative stress contribute to apoptosis of cardiac cells through mitochondrial dependent and independent pathways. Biochim. Biophys. Acta 2012, 1820:907-920.
16. Mehri S., Mahjoub S., Finsterer J., Zaroui A., Mechmeche R., Baudin B., Hammami M. The CC genotype of the angiotensin II type I receptor gene independently associates with acute myocardial infarction in a Tunisian population. J. Renin Angiotensin Aldosterone Syst. 2011, 12:595-600.
17. Nemer, M., Dali-Youcef, N., Wang, H., Aries, A., Paradis, P., 2006. Mechanisms of angiotensin II-dependent progression to heart failure. Novartis Found Symp 274, 58-68; discussion 68-72, 152-155, 272-156.
18. Oi N., Chen H., Ok Kim M., Lubet R.A., Bode A.M., Dong Z. Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K. Cancer Prev. Res. (Phila) 2012, 5:1103-1114.
19. Park C., So H.S., Shin C.H., Baek S.H., Moon B.S., Shin S.H., Lee H.S., Lee D.W., Park R. Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfunction in H9c2 cardiomyoblast cells. Biochem. Pharmacol. 2003, 66:1287-1295.
20. Roe N.D., Thomas D.P., Ren J. Inhibition of NADPH oxidase alleviates experimental diabetes-induced myocardial contractile dysfunction. Diabetes Obes. Metab. 2011, 13:465-473.
21. Sadoshima J., Xu Y., Slayter H.S., Izumo S. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993, 75:977-984.
22. Schannwell C.M., Schneppenheim M., Perings S., Plehn G., Strauer B.E. Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy. Cardiology 2002, 98:33-39.
23. Schieffer B., Luchtefeld M., Braun S., Hilfiker A., Hilfiker-Kleiner D., Drexler H. Role of NAD(P)H oxidase in angiotensin II-induced JAK/STAT signaling and cytokine induction. Circ. Res. 2000, 87:1195-1201.
24. Shaw J.E., Sicree R.A., Zimmet P.Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 2010, 87:4-14.
25. Shirpoor A., Salami S., Khadem-Ansari M.H., Ilkhanizadeh B., Pakdel F.G., Khademvatani K. Cardioprotective effect of vitamin E: rescues of diabetes-induced cardiac malfunction, oxidative stress, and apoptosis in rat. J. Diabetes Complications 2009, 23:310-316.
26. Singh V.P., Le B., Khode R., Baker K.M., Kumar R. Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis. Diabetes 2008, 57:3297-3306.
27. Stefek M., Sotnikova R., Okruhlicova L., Volkovova K., Kucharska J., Gajdosik A., Gajdosikova A., Mihalova D., Hozova R., Tribulova N., Gvozdjakova A. Effect of dietary supplementation with the pyridoindole antioxidant stobadine on antioxidant state and ultrastructure of diabetic rat myocardium. Acta Diabetol. 2000, 37:111-117.
28. Vladimirov Y.A., Proskurnina E.V., Demin E.M., Matveeva N.S., Lubitskiy O.B., Novikov A.A., Izmailov D.Y., Osipov A.N., Tikhonov V.P., Kagan V.E. Dihydroquercetin (taxifolin) and other flavonoids as inhibitors of free radical formation at key stages of apoptosis. Biochemistry (Mosc) 2009, 74:301-307.
29. Voulgari C., Papadogiannis D., Tentolouris N. Diabetic cardiomyopathy: from the pathophysiology of the cardiac myocytes to current diagnosis and management strategies. Vasc Health Risk Manage. 2010, 6:883-903.
30. Wagner M., Siddiqui M.A. Signaling networks regulating cardiac myocyte survival and death. Curr. Opin. Invest. Drugs 2009, 10:928-937.
31. Wang Y.H., Wang W.Y., Chang C.C., Liou K.T., Sung Y.J., Liao J.F., Chen C.F., Chang S., Hou Y.C., Chou Y.C., Shen Y.C. Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. J. Biomed. Sci. 2006, 13:127-141.
32. Watanabe K., Thandavarayan R.A., Harima M., Sari F.R., Gurusamy N., Veeraveedu P.T., Mito S., Arozal W., Sukumaran V., Laksmanan A.P., Soetikno V., Kodama M., Aizawa Y. Role of differential signaling pathways and oxidative stress in diabetic cardiomyopathy. Curr. Cardiol. Rev. 2010, 6:280-290.
33. Weidmann A.E. Dihydroquercetin: More than just an impurity?. Eur. J. Pharmacol. 2012, 684:19-26.