Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure

Journal of Cardiovascular Pharmacology

Volumn 53, Issue 1, 2009, Pages 9-17

  Ulu, Nadir ^a   Henning, Rob H ^a   Goris, Maaike ^a   Schoemaker, Regien G ^a   Van Gilst, Wiek H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Angiogenesis; Endothelial dysfunction; Heart failure; Heart rate; Myocardial infarction

Indexed keywords

ACETYLCHOLINE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; IVABRADINE; METOPROLOL; NITRIC OXIDE; PROSTAGLANDIN; BENZAZEPINE DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CAPILLARY DENSITY; CONTROLLED STUDY; CORONARY HEMODYNAMICS; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE RELAXATION; HEART RATE; HEART WEIGHT; HISTOPATHOLOGY; MALE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; THORACIC AORTA; ANIMAL; COMPLICATION; DRUG EFFECTS; HEART LEFT VENTRICLE FUNCTION; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; BENZAZEPINES; HEART FAILURE; HEART RATE; MALE; METOPROLOL; MYOCARDIAL INFARCTION; RATS; RATS, WISTAR; VENTRICULAR DYSFUNCTION, LEFT;

EID: 67651083386     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318193dfce     Document Type: Article

References (31)

1. Anversa P, Loud AV, Levicky V, et al. Left ventricular failure induced by myocardial infarction. II. Tissue morphometry. Am J Physiol. 1985;248: H883-H889. (Pubitemid 16239866)
2. Packer M. Treatment of chronic heart failure. Lancet. 1992;340:92-95.
3. Payne TR, Oshima H, Okada M, et al. A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J Am Coll Cardiol. 2007; 50:1677-1684. (Pubitemid 47562673)
4. Westenbrink BD, Lipsic E, van der Meer P, et al. Erythropoietin improves cardiac function through endothelial progenitor cell and vascular endothelial growth factor mediated neovascularization. Eur Heart J. 2007;28:2018-2027. (Pubitemid 47579534)
5. Zheng W, Brown MD, Brock TA, et al. Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor. Circ Res. 1999;85:192-198. (Pubitemid 29343318)
6. Van Kerckhoven R, van Veghel R, Saxena PR, et al. Pharmacological therapy can increase capillary density in post-infarction remodeled rat hearts. Cardiovasc Res. 2004;61:620-629. (Pubitemid 38210167)
7. Schoemaker RG, Saxena PR, Kalkman EA. Low-dose aspirin improves in vivo hemodynamics in conscious, chronically infarcted rats. Cardiovasc Res. 1998;37:108-114.
8. Prabhu SD, Chandrasekar B, Murray DR, et al. Beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. Circulation. 2000;101:2103-2109. (Pubitemid 30233176)
9. Zelis R, Flaim SF. Alterations in vasomotor tone in congestive heart failure. Prog Cardiovasc Dis. 1982;24:437-459.
10. Westendorp B, Schoemaker RG, van Gilst WH, et al. Improvement of EDHF by chronic ACE inhibition declines rapidly after withdrawal in rats with myocardial infarction. J Cardiovasc Pharmacol. 2005;46:766-772. (Pubitemid 44378248)
11. Thai H, Guarraia D, Johnson N, et al. Valsartan therapy in heart failure after myocardial infarction: the role of endothelial dependent vasorelaxation. J Cardiovasc Pharmacol. 2007;50:703-707. (Pubitemid 350307042)
12. Loot AE, Roks AJ, Henning RH, et al. Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats. Circulation. 2002;105:1548-1550.
13. Thollon C, Cambarrat C, Vian J, et al. Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br J Pharmacol. 1994; 112:37-42. (Pubitemid 24151700)
14. Mulder P, Barbier S, Chagraoui A, et al. Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation. 2004;109:1674-1679. (Pubitemid 38451726)
15. Dedkov EI, Zheng W, Christensen LP, et al. Preservation of coronary reserve by ivabradine-induced reduction in heart rate in infarcted rats is associated with decrease in perivascular collagen. Am J Physiol Heart Circ Physiol. 2007;293:H590-H598.
16. Maczewski M, Mackiewicz U. Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart. Cardiovasc Res. 2008;79:42-51. (Pubitemid 351881928)
17. Drouin A, Gendron ME, Thorin E, et al. Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice. Br J Pharmacol. 2008;154:749-757. (Pubitemid 351821579)
18. Roberts R, Rogers WJ, Mueller HS, et al. Immediate versus deferred betablockade following thrombolytic therapy in patients with acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI) II-B Study. Circulation. 1991;83:422-437.
19. Pinto YM, de Smet BG, van Gilst WH, et al. Selective and time related activation of the cardiac renin-angiotensin system after experimental heart failure: relation to ventricular function and morphology. Cardiovasc Res. 1993;27:1933-1938.
20. Windt WA, Tahara A, Kluppel AC, et al. Early, but not late therapy with a vasopressin V1a-antagonist ameliorates the development of renal damage after 5/6 nephrectomy. J Renin Angiotensin Aldosterone Syst. 2006;7: 217-224. (Pubitemid 46380772)
21. Pfeffer JM, Pfeffer MA, Fletcher PJ, et al. Progressive ventricular remodeling in rat with myocardial infarction. Am J Physiol. 1991;260: H1406-H1414.
22. Xydas S, Kherani AR, Chang JS, et al. Beta(2)-adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy. J Pharmacol Exp Ther. 2006;317:553-561.
23. Crampton EW, Lloyd LE. The effect of water restriction on the food intake and food efficiency of growing rats. J Nutr. 1954;54:221-224.
24. Lei L, Zhou R, Zheng W, et al. Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. Circulation. 2004;110:796-802. (Pubitemid 39096006)
25. Ahmet I, Lakatta EG, Talan MI. Pharmacological stimulation of beta2- adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy. Heart Fail Rev. 2005;10:289-296.
26. Kobayashi M, Machida N, Mitsuishi M, et al. Beta-blocker improves survival, left ventricular function, and myocardial remodeling in hypertensive rats with diastolic heart failure. Am J Hypertens. 2004;17: 1112-1119. (Pubitemid 40029408)
27. Cherng WJ, Liang CS, Hood WB Jr. Effects of metoprolol on left ventricular function in rats with myocardial infarction. Am J Physiol. 1994;266:H787-H794. (Pubitemid 24104826)
28. Gschwend S, Buikema H, Henning RH, et al. Endothelial dysfunction and infarct-size relate to impaired EDHF response in rat experimental chronic heart failure. Eur J Heart Fail. 2003;5:147-154. (Pubitemid 36383621)
29. Indik J, Goldman S, Gaballa M. Oxidative stress contributes to vascular endothelial dysfunction in heart failure. Am J Physiol Heart Circ Physiol. 2001;281:H1767-H1770. (Pubitemid 32948224)
30. Custodis F, Baumhäkel M, Schlimmer N, et al. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2008;117:2377-2387. (Pubitemid 351653554)
31. Vercauteren M, Favre J, Mulder P, et al. Protection of endothelial function by long term heart rate reduction induced by ivabradine in a rat model of chronic heart failure [abstract]. Eur Heart J. 2007;28(Suppl 1):48.