Histone demethylase KDM1A represses inflammatory gene expression in preadipocytes

Obesity

Volumn 21, Issue 12, 2013, Pages

  Hanzu, Felicia A ^a,b   Musri, Melina M ^a   Sánchez Herrero, Alvaro ^a   Claret, Marc ^a   Esteban, Yaiza ^a   Kaliman, Perla ^a   Gomis, Ramon ^a,b   Párrizas, Marcelina ^a  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; HISTONE DEMETHYLASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HYBRIDIZATION; KDM1A GENE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROADIPOCYTE; RCOR2 GENE; REPRESSOR GENE; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL DIFFERENTIATION; CELL LINE; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HISTONE DEMETHYLASES; HUMANS; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, OBESE; NERVE TISSUE PROTEINS; NF-KAPPA B; OXIDOREDUCTASES, N-DEMETHYLATING; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; RNA, SMALL INTERFERING;

EID: 84889666133     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20479     Document Type: Article

References (40)

1. Olefsky JM, Glass CK,. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010; 72: 219-246.
2. Rodeheffer MS, Birsoy K, Friedman JM,. Identification of white adipocyte progenitor cells in vivo. Cell 2008; 135: 240-249.
3. Isakson P, Hammarstedt A, Gustafson B, et al. Impaired preadipocyte differentiation in human abdominal obesity: role of Wnt, tumor necrosis factor-alpha, and inflammation. Diabetes 2009; 58: 1550-1557.
4. Tchoukalova Y, Koutsari C, Jensen M,. Committed subcutaneous preadipocytes are reduced in human obesity. Diabetologia 2007; 50: 151-157.
5. Arner P, Arner E, Hammarstedt A, et al. Genetic predisposition for Type 2 diabetes, but not for overweight/obesity, is associated with a restricted adipogenesis. PLoS ONE 2011; 6: e18284.
6. McLaughlin T, Sherman A, Tsao P, et al. Enhanced proportion of small adipose cells in insulin-resistant vs. insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia 2007; 50: 1707-1715.
7. Kim JY, van de WE, Laplante M, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007; 117: 2621-2637.
8. Liu A, Sonmez A, Yee G, et al. Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats. Diab Vasc Dis Res 2010; 7: 311-318.
9. Charriere G, Cousin B, Arnaud E, et al. Preadipocyte conversion to macrophage. Evidence of plasticity. J Biol Chem 2003; 278: 9850-9855.
10. Gustafson B, Smith U,. Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes. J Biol Chem 2006; 281: 9507-9516.
11. Li Y, Reddy MA, Miao F, et al. Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kB-dependent inflammatory genes. Relevance to diabetes and inflammation. J Biol Chem 2008; 283: 26771-26781.
12. Okabe J, Orlowski C, Balcerczyk A, et al. Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells. Circ Res 2012; 110: 1067-1076.
13. Villeneuve LM, Reddy MA, Lanting LL, et al. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci USA 2008; 105: 9047-9052.
14. Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119: 941-953.
15. Metzger E, Wissmann M, Yin N, et al. LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 2005; 437: 436-439.
16. Musri MM, Carmona MC, Hanzu FA, et al. Histone demethylase LSD1 regulates adipogenesis. J Biol Chem 2010; 285: 30034-30041.
17. Kwok BH, Koh B, Ndubuisi MI, et al. The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkB kinase. Chem Biol 2001; 8: 759-766.
18. Li C, Wong WH,. Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 2001; 98: 31-36.
19. Mack I, BelAiba RS, Djordjevic T, et al. Functional analyses reveal the greater potency of preadipocytes compared with adipocytes as endothelial cell activator under normoxia, hypoxia, and TNFα exposure. Am J Physiol Endocrinol Metab 2009; 297: E735-E748.
20. Shi YJ, Matson C, Lan F, et al. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell 2005; 19: 857-864.
21. Yang P, Wang Y, Chen J, et al. RCOR2 is a subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency. Stem Cells 2011; 29: 791-801.
22. Musri MM, Parrizas M,. Epigenetic regulation of adipogenesis. Curr Opin Clin Nutr Metab Care 2012; 15: 342-349.
23. Chavey C, Lazennec G, Lagarrigue S, et al. CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab 2009; 9: 339-349.
24. Samaras K, Botelho NK, Chisholm DJ, et al. Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes. Obesity 2010; 18: 884-889.
25. Olofsson PS, Jatta K, Wagsater D, et al. The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Arterioscler Thromb Vasc Biol 2005; 25: e113-e116.
26. Hanzu FA, Palomo M, Kalko SG, et al. Translational evidence of endothelial damage in obese individuals: inflammatory and prothrombotic responses. J Thromb Haemost 2011; 9: 1236-1245.
27. Ades EW, Candal FJ, Swerlick RA, et al. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992; 99: 683-690.
28. Chae GN, Kwak SJ,. NF-kB is involved in the TNF-α induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARγ expression. Exp Mol Med 2003; 35: 431-437.
29. Ito Y, Daitoku H, Fukamizu A,. Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes. Biochem Biophys Res Commun 2009; 378: 290-295.
30. Hu HM, Tian Q, Baer M, et al. The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. J Biol Chem 2000; 275: 16373-16381.
31. Kunsch C, Lang RK, Rosen CA, et al. Synergistic transcriptional activation of the IL-8 gene by NF-KB p65 (RelA) and NF-IL6. J Immunol 1994; 153: 153-164.
32. Xia C, Cheshire JK, Patel H, et al. Cross-talk between transcription factors NF-kB and C/EBP in the transcriptional regulation of genes. Int J Biochem Cell Biol 1997; 29: 1525-1539.
33. Saijo K, Winner B, Carson CT, et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009; 137: 47-59.
34. Rahman SM, Janssen RC, Choudhury M, et al. CCAAT/enhancer-binding protein beta (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice. J Biol Chem 2012; 287: 34349-34360.
35. Feng R, Desbordes SC, Xie H, et al. PU.1 and C/EBPα/β convert fibroblasts into macrophage-like cells. Proc Natl Acad Sci USA 2008; 105: 6057-6062.
36. Abdou HS, Atlas E, Hache RJ,. Liver-enriched inhibitory protein (LIP) actively inhibits preadipocyte differentiation through histone deacetylase 1 (HDAC1). J Biol Chem 2011; 286: 21488-21499.
37. Spooner CJ, Guo X, Johnson PF, et al. Differential roles of C/EBPβ regulatory domains in specifying MCP-1 and IL-6 transcription. Mol Immunol 2007; 44: 1384-1392.
38. Tang QQ, Otto C, Lane MD,. CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesis. Proc Natl. Acad Sci USA 2003; 100: 850-855.
39. Zhang JW, Tang QQ, Vinson C, et al. Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 2004; 101: 43-47.
40. Virtue S, Vidal-Puig A,. Adipose tissue expandability, lipotoxicity and the metabolic syndrome-an allostatic perspective. Biochim Biophys Acta 2010; 1801: 338-349.