Estimation of chloroform inhalation dose by other routes based on the relationship of area under the blood concentration-time curve (AUC)-inhalation dose to chloroform distribution in the blood of rats

Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

Volumn 49, Issue 3, 2014, Pages 253-261

  Take, Makoto ^a   Takeuchi, Tetsuya ^a   Haresaku, Mitsuru ^a   Matsumoto, Michiharu ^a   Nagano, Kasuke ^b   Yamamoto, Seigo ^c   Takamura Enya, Takeji ^c   Fukushima, Shoji ^a  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

^b Nagano Toxicologic Pathology Consulting   (Japan)

^c KANAGAWA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Area under the blood concentration time curve; Blood concentration; Chloroform; Inhalation; Inhalation equivalent dose

Indexed keywords

BLOOD CONCENTRATIONS; CONCENTRATION-TIME; EQUIVALENT DOSE; EXPOSURE PERIOD; GOOD CORRELATIONS; INHALATION; INHALATION EXPOSURE; ORAL ADMINISTRATION;

ANTHROPOMETRY; CHLORINE COMPOUNDS; RATS; RISK ASSESSMENT; VOLATILE ORGANIC COMPOUNDS;

BLOOD;

CHLOROFORM;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPOSURE; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; RISK ASSESSMENT;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHLOROFORM; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84889633118     PISSN: 10934529     EISSN: 15324117     Source Type: Journal    
DOI: 10.1080/10934529.2014.846191     Document Type: Article

References (22)

1. International Agency for Research on Cancer (IARC). Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances. IARC Monogr. Eval. Carcinog. Risks Hum. 1999, 73, 131-182.
2. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Chloroform. ATSDR: Atlanta, GA, 1997. Available at www.atsdr.cdc.gov/toxprofiles/tp6.html (accessed July 2013).
3. Ministry of the Environment Government of Japan. Pollutant Release and Transfer Register. Tokyo: Environmental Health and Safety Division, Environmental Health Department, Ministry of the Environment Government of Japan. 2011. Available atwww.env. go.jp/en/chemi/prtr/substances/index.html (accessed July 2013).
4. Andelman, J.B. Human exposures to volatile halogenated organic chemicals in indoor and outdoor air. Environ. Health Perspect. 1985, 62, 313-318.
5. Ministry of the Environment Government of Japan. Chemicals in the Environment, Fiscal year 2002. Environmental Health and Safety Division, Environmental Health Department, Ministry of the Environment Government of Japan: Tokyo, 2003. (In Japanese).
6. Schoeny, R.; Haber, L.; Dourson, M. Data considerations for regulation of water contaminants. Toxicology 2006, 221, 217-224.
7. World Health Organization (WHO). Trihalomethanes in drinkingwater. Background document for development of WHO guidelines for drinking-water quality. WHO/SDE/WSH/05.08/64; Author: Geneva, 2005.
8. Boorman, G.A.; Dellarco, V.; Dunnick, J.K.; Chapin, R.E.; Hunter, S.; Hauchman, F.; Gardner, H.; Cox, M.; Sills, R.C. Drinking water disinfection byproducts: reviewand approach to toxicity evaluation. Environ. Health Perspect. 1999, 107, 207-217.
9. Riederer, A.M.; Bartell, S.M.; Ryan, P.B. Predictors of personal air concentrations of chloroform among US adults in NHANES 1999-2000. J. Expo. Sci. Environ. Epidemiol. 2009, 19, 248-259.
10. Yamamoto, S.; Kasai, T.; Matsumoto, M.; Nishizawa, T.; Arito, H.; Nagano, K.; Matsushima, T. Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation. J. Occup. Health 2002, 44, 283-293.
11. National Cancer Institute (NCI). Report on Carcinogenesis Bioassay of Chloroform. NTIS PB-264-018; National Cancer Institute: Bethesda, MD, 1976.
12. Jorgenson, T.A.; Meierhenry, E.F.; Rushbrook, C.J.; Bull, R.J.; Robinson, M. Carcinogenicity of chloroform in drinking water to male Osborne-Mendel rats and female B6C3F1 mice. Fundam. Appl. Toxicol. 1985, 5, 760-769.
13. Nagano, K.; Kano, H.; Arito, H.; Yamamoto, S.; Matsushima, T. Enhancement of renal carcinogenicity by combined inhalation and oral exposures to chloroform in male rats. J. Toxicol. Environ. Health Pt. A 2006, 69, 1827-1842.
14. Ministry of the Environment of Japan. Guideline for the Initial Risk Assessment of Chemicals. Tokyo: Environmental Health and Safety Division, Environmental Health Department, Ministry of the Environment Government of Japan: Tokyo, 2013. Available at http://www.env.go.jp/chemi/report/h24-02/pdf/ chpt1/1-2-1.pdf (accessed July 2013) (In Japanese).
15. Wang, P.Y.; Kaneko, T.; Tsukada, H.; Sato, A. Dose and route dependency of metabolism and toxicity of chloroform in ethanoltreated rats. Arch. Toxicol. 1994, 69, 18-23.
16. Wang, P.Y.; Kaneko, T.; Sato, A.; Charboneau, M.; Plaa, G.L. Doseand route-dependent alteration of metabolism and toxicity of chloroformin fed and fasting rats. Toxicol. Appl. Pharmacol. 1995, 135, 119-126.
17. Withey, J.R.; Collins, B.T.; Collins, P.G. Effect of vehicle on the pharmacokinetics and uptake of four halogenated hydrocarbons from the gastrointestinal tract of the rat. J. Appl. Toxicol. 1983, 3, 249-253.
18. Take, M.; Yamamoto, S.; Ohnishi, M.; Matsumoto, M.; Nagano, K.; Hirota, T.; Fukushima, S. Chloroform distribution and accumulation by combined inhalation plus oral exposure routes in rats. J. Environ. Sci. Health Pt. A 2010, 45, 1616-1624.
19. Take, M.; Ohnishi, M.; Nagano, K.; Yamamoto, S.; Fukushima, S. Design and performance of a system for blood collection of rats under whole-body inhalation exposure. J. Toxicol. Sci. 2009, 34, 221-226.
20. National Research Council (NRC). Guide for the Care and Use of Laboratory Animals; National Academy Press: Washington, DC, 1996.
21. Rozman, K.K.; Klaassen, C.D. Absorption, distribution, and excretion of toxicants. Casarett & Doull's Toxicology, 6th Ed.; McGraw-Hill Companies, Inc.: New York, 2001; 91-111.
22. Sasso, A.F.; Schlosser, P.M.; Kedderis, G.L.; Genter, M.B.; Snawder, J.E.; Li, Z.; Rieth, S.; Lipscombll, J.C. Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice. Toxicol. Sci. 2013, 131, 360-374.