Design and performance of a system for blood collection of rats under whole-body inhalation exposure

Journal of Toxicological Sciences

Volumn 34, Issue 2, 2009, Pages 221-226

  Take, Makoto ^a   Ohnishi, Makoto ^a   Nagano, Kasuke ^a   Yamamoto, Seigo ^a   Fukushima, Shoji ^a  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

Author keywords

Blood collection; Chloroform; Rats; Whole body inhalation exposure system

Indexed keywords

CHLOROFORM; VOLATILE ORGANIC COMPOUND;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; DIAGNOSTIC TEST; DRUG BLOOD LEVEL; EXPOSURE; FLOW RATE; MALE; NONHUMAN; RAT; WHOLE BODY INHALATION EXPOSURE SYSTEM;

ANIMALIA; RATTUS;

EID: 66149166070     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.221     Document Type: Article

References (9)

1. CERI News (2005): http://www.cerij.or.jp/cerinews/cn-pdf/cerinews-051. pdf.
2. Hori, H., Ishidao, T., Oyabu, T., Yamato, H., Morimoto, Y. and Tanaka, I. (1999): Effect of simultaneous exposure to methanol and toluene vapor on their metabolites in rats. J. Occup. Health, 41, 149-153.
3. International Agency for Research on Cancer (IARC) (1999): Chloroform. In IARC Monographs on the Evaluation of Carcinogenic risks to Humans. Some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances. Vol.73, pp.131-182, IARC, Lyon.
4. International Programme on Chemical Safety (IPCS) (1994): Environmental Health Criteria 163 Chloroform. World Health Organization (WHO), Geneva.
5. Kaneko, T., Wang, P.Y., Tsukada, H. and Sato, A. (1995): m-Xylene toxicokinetics in phenobarbital-treated rats: comparison among inhalation exposure, oral administration, and intraperitoneal administration. Toxicol. Appl. Pharmacol., 131, 13-20.
6. Nagano, K., Kano, H., Arito, H., Yamamoto, S. and Matsushima, T. (2006): Enhancement of renal carcinogenicity by combined inhalation and oral exposures to chloroform in male rats. J. Toxicol. Environ. Health, A, 69, 1827-1842.
7. National Research Council (1996): Guide for the Care and Use of Laboratory Animals, National Academy Press, Washington, D.C..
8. Wang, P.Y., Kaneko, T., Sato A., Charboneau, M. and Plaa, G.L. (1995): Dose- and route-dependent alteration of metabolism and toxicity of chloroform in fed and fasting rats. Toxicol. Appl. Pharmacol., 135, 119-126.
9. Yamamoto, S., Kasai, T., Matsumoto, M., Nishizawa, T., Arito, H., Nagano, K. and Matsushima, T. (2002): Carcinogenicity and chronic toxicity in rats and mice exposed to chloroform by inhalation. J. Occup. Health, 44, 283-293.