Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC Min/+ mice

Oncogene

Volumn 29, Issue 10, 2010, Pages 1553-1560

  Koehl, G E ^a   Spitzner, M ^b   Ousingsawat, J ^b   Schreiber, R ^b   Geissler, E K ^a   Kunzelmann, K ^b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

APCMin + + mice; Familial adenomatous polyposis; Ion channels; MTOR; Rapamycin; Sirolimus

Indexed keywords

APC PROTEIN; EPITHELIAL SODIUM CHANNEL; ION CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; POTASSIUM CHANNEL; RAPAMYCIN; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR ERG1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SURVIVAL; CARCINOGENESIS; CONTROLLED STUDY; GENE MUTATION; INTESTINAL BLEEDING; INTESTINE CANCER; LONG TERM CARE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CODON, NONSENSE; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL NEOPLASMS; INTESTINAL POLYPS; INTESTINES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ION CHANNELS; MICE; PROTEIN-SERINE-THREONINE KINASES; SIROLIMUS; WEIGHT LOSS;

MAMMALIA; MUS;

EID: 77949425311     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.435     Document Type: Article

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