Is irisin an early marker of statin-induced myopathy? Bench to the bedside

Clinical Lipidology

Volumn 8, Issue 6, 2013, Pages 623-625

  Pothineni, Naga Venkata ^a   Ding, Zufeng ^a   Mehta, Jawahar L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

ezetimibe; irisin; lipid metabolism; simvastatin; skeletal muscle cell

Indexed keywords

CHOLESTEROL; EZETIMIBE; FIBRONECTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRISIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN RECEPTOR; SIMVASTATIN; UBIDECARENONE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; DISEASE MARKER; FNDC5 GENE; GENE; HUMAN; MYOPATHY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

EID: 84889587952     PISSN: 17584299     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.13.71     Document Type: Article

References (7)

1. Huh JY, Panagiotou G, Mougios V et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61(12), 1725-1738 (2012
2. Gouni-Berthold I, Berthold HK, Huh JY, Berman R, Spenrath N, Krone W, Mantzoros CS. Effects of lipid-lowering drugs on irisin in human subjects in vivo and in human skeletal muscle cells ex vivo. PLoS ONE 8(9), e72858 (2013
3. Berthold HK, Naini A, Di Mauro S et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: A randomized trial. Drug Saf. 29(8), 703-712 (2006 (Pubitemid 44175041)
4. Bostrom P, Wu J, Jedrychowski MP et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481(7382), 463-468 (2012
5. Mikus CR, Boyle LJ, Borengasser SJ et al. Simvastatin impairs exercise training adaptations. J. Am. Coll. Cardiol. 62(8), 709-714 (2013
6. Goodpaster BH. Mitochondrial deficiency is associated with insulin resistance. Diabetes 62(4), 1032-1035 (2013
7. Kelly DP. Medicine. Irisin, light my fire. Science 336(6077), 42-43 (2012)