A novel expression based approach for assessing the inactivation status of human X-linked genes

European Journal of Human Genetics

Volumn 8, Issue 2, 2000, Pages 103-108

  Benjamin, Don ^b   Van Bakel, Inge ^b   Craig, Ian W ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NONE

Author keywords

Dosage compensation; Novel method; RT PCR; X inactivation

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; ANDROGEN RECEPTOR; COMPLEMENTARY DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ALLELE; ARTICLE; CELL CLONING; DNA POLYMORPHISM; FATHER; GENE AMPLIFICATION; GENE EXPRESSION; GENE INACTIVATION; HUMAN; HUMAN CELL; MOTHER; PRIORITY JOURNAL; RECEPTOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; X CHROMOSOME LINKAGE;

CELL LINE; DNA; DNA, COMPLEMENTARY; DOSAGE COMPENSATION, GENETIC; FEMALE; FRAGILE X MENTAL RETARDATION PROTEIN; GENE EXPRESSION REGULATION; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LINKAGE (GENETICS); MICROSATELLITE REPEATS; MONOAMINE OXIDASE; NERVE TISSUE PROTEINS; RECEPTORS, ANDROGEN; RNA-BINDING PROTEINS; X CHROMOSOME;

EID: 0034103261     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200427     Document Type: Article

References (21)

1. Lyon MF: Some milestones in the history of X chromosome inactivation. Annu Rev Genet 1992; 26: 17-28.
2. Miller AP, Gustashaw K, Wolff DJ et al: Three genes that escape X chromosome inactivation are clustered within a 6Mb YAC contig and STS map in Xp11.21-p11.22. Hum Mol Genet 1995; 4: 731-739.
3. Carrel L, Clemson CM, Dunn JM et al: X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Hum Mol Genet 1996; 5: 391-401.
4. Disteche CM: Escape from X inactivation in humans and mouse. Trends Genet 1995; 11: 17-22.
5. Wu J, Salido EC, Yen PH, Mohandas TK et al: The murine Xe169 gene escapes X inactivation like its human homologue. Nat Genet 1994; 7: 491-496.
6. Greenfield A, Carrel L, Pennisi D et al: The UTX gene escapes X-inactivation in mice and humans. Hum Mol Genet 1998; 7: 737-742.
7. Schneider-Gadicke A, Beer-Romero P, Brown LG, Nussbaum R, Page DC: The ZFX gene on the human X chromosome escapes X inactivation and is closely related to ZFY, the putative sex determinant on the Y chromosome. Cell 1989; 57: 1247-1258.
8. Fisher EMC, Beer-Romero P, Brown LG et al: Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner Syndrome. Cell 1990; 63: 1205-1218.
9. Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW: Methylation of HpaII and Hhal sites near the polymorphic CAG repeat in the human androgen receptor gene correlates with X chromosome inactivation. Am J Hum Genet 1992; 51: 1229-1239.
10. Hendriks RW, Chen Z-Y, Hinds H, Schuurman RKB, Craig IW: An X chromosome inactivation assay based on differential methylation of a CpG island coupled to a VNTR polymorphism at the 5‰ end of the monoamine oxidase A gene. Hum Mol Genet 1992; 1: 87-94.
11. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidinium thiocyanate phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
12. Yan D, Wong D, Zheng K et al: Dinucleotide repeat polymorphism at the DXS977 locus. Hum Mol Genet 1994; 3: 1030.
13. Fu YH, Kuhl DPA, Pizzuti A et al: Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell 1991; 67: 1047-1058.
14. Edwards A, Hammond JA, Jin L, Caskey CT, Chakraborty R: Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 1992; 12: 241-253.
15. Brown CJ, Carrel L, Willard HF: Expression of genes from the human active and inactive X chromosomes. Am J Hum Genet 1997; 60: 1333-1343.
16. Swaroop A, Xu J, Agarwal N, Weissman SM: A simple and efficient cDNA library subtraction procedure: isolation of human retina specific cDNA clones. Nucleic Acids Res 1991; 19: 1954.
17. Nelson DL, Ballabio A, Cremers F, Monaco AP, Schlessinger D: Report of the Sixth International Workshop on X chromosome Mapping 1995. Cytogenet Cell Genet 1995; 71: 307-342.
18. Jones MH, Furlong RA, Burkin H et al: The drosophila developmental gene fat facets has a human homologue in Xp11.4 which escapes X-inactivation and has related sequences on Yq11.2. Hum Mol Genet 1996; 5: 1695-1701.
19. Esposito T, Gianfrancesco F, Ciccodicola A et al: Escape from X-inactivation of two new genes associated with DXS6974E and DXS7020E. Genomics 1997; 43: 183-190.
20. Bressler SL, Lee KH, Adler DA, Chapman VM, Disteche CM: Maintenance of X inactivation of the Rps4, Zfx and Ubel genes in a mouse in vitro system. Somat Cell Molec Genet 1993; 19-29-37.
21. Gartler SM, Goldman MA: Reactivation of inactive X linked genes Dev Genet 1994; 15: 504-514.