Molecular docking studies of marine diterpenes as inhibitors of wild-type and mutants HIV-1 reverse transcriptase

Marine Drugs

Volumn 11, Issue 11, 2013, Pages 4127-4143

  Miceli, Leonardo A ^a   Teixeira, Valéria L ^a   Castro, Helena C ^a   Rodrigues, Carlos R ^b   Mello, Juliana F R ^b   Albuquerque, Magaly G ^b   Cabral, Lucio M ^b   De Brito, Monique A ^a   De Souza, Alessandra M T ^b  

^a FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Antiviral; Brown algae diterpenes; HIV 1; Molecular docking; Mutants; Reverse transcriptase

Indexed keywords

6 ACETOXYDICHOTOMA 3,14 DIENE 1,17 DIAL; 6 HYDROXYDICHOTOMA 3,14 DIENE 1,17 DIAL; DITERPENE; DOLABELLADIENOTRIOL; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; BROWN ALGA; CONTROLLED STUDY; DICTYOTA; DRUG BINDING; DRUG ISOLATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; HYDROPHOBICITY; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS 1; PHAEOPHYCEAE;

ANTI-HIV AGENTS; BINDING SITES; DITERPENES; HIV REVERSE TRANSCRIPTASE; HIV-1; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DOCKING SIMULATION; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84889240561     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11114127     Document Type: Article

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