Polymeric nanocarriers for magnetic targeted drug delivery: Preparation, characterization, and in vitro and in vivo evaluation

Molecular Pharmaceutics

Volumn 10, Issue 12, 2013, Pages 4397-4407

  Licciardi, Mariano ^a   Scialabba, Cinzia ^a   Fiorica, Calogero ^a   Cavallaro, Gennara ^a   Cassata, Giovanni ^b   Giammona, Gaetano ^a,c  

^a UNIVERSITY OF PALERMO   (Italy)

^b ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELLA SICILIA A MIRRI   (Italy)

^c CNR   (Italy)

Author keywords

flutamide; magnetic nanocarrier; magnetic targeting; superparamagnetic nanoparticles

Indexed keywords

ALPHA,BETA POLY( N 2 HYDROXYETHYL)ASPARTAMIDE CO ( N 2 ETHYLENE ISOBUTYRIC ACID) GRAFT POLY(BUTYL METHACRYLIC ACID); COPOLYMER; FLUTAMIDE; HYDROXYFLUTAMIDE; MAGNETIC NANOCARRIER; MAGNETIC NANOPARTICLE; NANOCARRIER; POLYMETHACRYLIC ACID DERIVATIVE; SOLVENT; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL TRANSPORT; CHEMICAL ANALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG SYNTHESIS; DYNAMIC LIGHT SCATTERING; EVAPORATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; MAGNET; MAGNETIC FIELD; MALE; MATERIAL COATING; MEASUREMENT; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; RAT; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FLUTAMIDE; HUMANS; MAGNETICS; MAGNETITE NANOPARTICLES; MALE; PARTICLE SIZE; PEPTIDES; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 84889239452     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300718b     Document Type: Article

References (38)

1. Safarik, I.; Safarikova, M. Magnetic nano- and microparticles in biotechnology Chem. Pap. 2009, 63, 497-505
2. Kumar, C. S. S. R.; Mohammad, F. Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery Adv. Drug Delivery Rev. 2011, 63, 789-808
3. Weissleder, R.; Stark, D. D.; Engelstad, B. L.; Bacon, B. R.; Compton, C. C.; White, D. L.; Jacobs, P.; Lewis, J. Superparamagnetic iron oxide: pharmacokinetics and toxicity Am. J. Roentgenol. 1989, 152, 167-173 (Pubitemid 19024086)
4. 4 nanoparticles in mice Int. J. Nanomed. 2010, 5, 861-866
5. Gupta, A. K.; Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications Biomaterials 2005, 26, 3995-4021 (Pubitemid 40044762)
6. Di Corato, R.; Piacenza, P.; Musaró, M.; Buonsanti, R.; Cozzoli, P. D.; Zambianchi, M.; Barbarella, G.; Cingolani, R.; Manna, L.; Pellegrino, T. Magnetic-Fluorescent Colloidal Nanobeads: Preparation and Exploitation in Cell Separation Experiments Macromol. Biosci. 2009, 9, 952-958
7. Lang, C.; Schüler, D.; Faivre, D. Synthesis of magnetite nanoparticles for bio- and nanotechnology: genetic engineering and biomimetics of bacterial magnetosomes Macromol. Biosci. 2007, 7, 144-151 (Pubitemid 47264209)
8. Rastogi, R.; Gulati, N.; Kotnala, R. K.; Sharma, U.; Jayasundar, R.; Koul, V. Evaluation of folate conjugated pegylated thermosensitive magnetic nanocomposites for tumor imaging and therapy Colloids Surf., B 2011, 82, 160-167
9. Vetter, A.; Reinisch, A.; Strunk, D.; Kremser, C.; Hahn, H. W.; Huck, C. W.; Ostermann, T.; Leithner, K.; Bernkop-Schnürch, A. Thiolated polyacrylic acid-modified iron oxide nanoparticles for in vitro labeling and MRI of stem cells J. Drug Target. 2011, 19, 562-572
10. Alexiou, C.; Jurgons, R.; Schmid, R. J.; Bergemann, C.; Henke, J.; Erhard, W.; Huenges, E.; Parak, F. Magnetic drug targeting-biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment J. Drug Target. 2003, 11, 139-149 (Pubitemid 37236327)
11. Huang, B. R.; Chen, P. Y.; Huang, C. Y.; Jung, S. M.; Ma, Y. H.; Wu, T.; Chen, J. P.; Wie, K. C. Bioavailability of magnetic nanoparticles to the brain J. Magn. Magn. Mater. 2009, 321, 1604-1609
12. Schweiger, C.; Pietzonka, C.; Heverhagen, J.; Kissel, T. Novel magnetic iron oxide nanoparticles coated with poly(ethylene imine)-g-poly(ethylene glycol) for potential biomedical application: Synthesis, stability, cytotoxicity and MR imaging Int. J. Pharmaceutics 2011, 408, 130-137
13. Laurent, S.; Forge, D.; Port, M.; Roch, A.; Robic, C.; Vander, E. L.; Muller, R. N. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications Chem. Rev. 2008, 108, 2064-2110
14. Arias, J. L.; Gallardo, V.; Gómez-Lopera, S. A.; Plazaand, R. C.; Delgado, A. V. Synthesis and characterization of poly(ethyl-2-cyanoacrylate) nanoparticles with a magnetic core J. Controlled Release 2001, 77, 309-321 (Pubitemid 33145482)
15. Arias, J. L.; Gallardo, V.; Ruiz, M. A.; Delgado, A. V. Magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles as 5-Fluorouracil delivery systems for active targeting Eur. J. Pharm. Biopharm. 2008, 69, 54-63
16. Tataru, G.; Popa, M.; Desbrieres, J. Magnetic microparticles based on natural polymers Int. J. Pharmaceutics 2011, 404, 83-93
17. Gupta, A. K.; Gupta, M. Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles Biomaterials 2005, 26, 1565-1573 (Pubitemid 39441388)
18. Zou, P.; Yu, Y.; Wang, Y. A.; Zhong, Y.; Welton, A.; Galbán, C.; Wang, S.; Sun, D. Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release Mol. Pharmaceutics 2010, 7, 1974-1984
19. 4 nanoparticles-loaded PEG-PLA polymeric vesicles as labels for ultrasensitive immunosensors Biomaterials 2010, 31, 7332-7339
20. Yang, X.; Hong, H.; Grailer, J. J.; Rowland, I. J.; Javadi, A.; Hurley, S. A.; Xiao, Y.; Yang, Y.; Zhang, Y.; Nickles, R. J.; Cai, W.; Steeber, D. A.; Gong, S. cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging Biomaterials 2011, 32, 4151-4160
21. Licciardi, M.; Scialabba, C.; Cavallaro, G.; Sangregorio, C.; Fantechi, E.; Giammona, G. Celle uptake enhancement of folate targeted polymer coated magnetic nanoparticles J. Biomed. Nanotechnol. 2013, 9, 949-964
22. Pradhan, P.; Giri, J.; Rieken, F.; Koch, C.; Mykhaylyk, O.; Döblinger, M.; Banerjee, R.; Bahadur, D.; Plank, C. Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy J. Controlled Release 2010, 142, 108-121
23. Geoffrey, D. B.; Alline, L.; Yanjing, C.; Kyle, S.; Linnea, E. A.; Matthew, A. S. Multicomponent folate-targeted magnetoliposomes: design, characterization, and cellular uptake Nanomedicine 2011, 7, 797-805
24. Clares, B.; Biedma-Ortiz, R. A.; Sáez-Fernández, E.; Prados, J. C.; Melguizo, C.; Cabeza, L.; Ortiz, R.; Arias, J. L. Nano-engineering of 5-fluorouracil-loaded magnetoliposomes for combined hyperthermia and chemotherapy against colon cancer. Eur. J. Pharm. Biopharm. 2013, 10.1016/j.ejpb.2013.01.028.
25. Ying, X. Y.; Du, Y. Z.; Hong, L. H.; Yuan, H.; Hu, F. Q. Magnetic lipid nanoparticles loading doxorubicin for intracellular delivery: Preparation and characteristics J. Magn. Magn. Mater. 2011, 323, 1088-1093
26. Peira, E.; Marzola, P.; Podio, V.; Aime, S.; Sbarbati, A.; Gasco, M. R. In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide J. Drug Target. 2003, 11, 19-24 (Pubitemid 36527392)
27. Giammona, G.; Carlisi, B.; Palazzo, S. J. Reaction of α,β-poly(N-2-hydroxyethyl)-DL aspartamide with derivatives of carboxylic acids Polym. Sci. Polym. Chem. 1987, 25, 2813-2818
28. Mendichi, R.; Giammona, G.; Cavallaro, G.; Giacometti Schieroni, A. Molecular characterization of alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide by light scattering and viscometry studies Polymer 2000, 41, 649-657
29. Cavallaro, G.; Licciardi, M.; Di Stefano, M.; Pitarresi, G.; Giammona, G. New self-assembling polyaspartamide-based brush copolymers obtained by atom transfer radical polymerization Macromolecules 2009, 42, 3247-3257
30. Licciardi, M.; Di Stefano, M.; Craparo, E. F.; Amato, G.; Cavallaro, G.; Fontana, G.; Giammona, G. PHEA-graft-polybutylmethacrylate copolymer microparticles for delivery of hydrophobic drugs Int. J. Pharmaceutics 2012, 433, 16-24
31. 3 films Phys. Rev. B 1974, 9, 3891-3897
32. Schieber, M. M. Iron oxides and their compounds in experimental magnetochemistry; Wohlfarth, E. P., Ed.; North-Holland Publishing Company: Amsterdam, 1967.
33. Millan, A.; Urtizberea, A.; Silva, N. J. O.; Palacio, F.; Amaral, V. S.; Snoeck, V.; Serin, V. Surface effects in maghemite nanoparticles J. Magn. Magn. Mater. 2007, 312, L5-L9
34. Néel, L. Théorie du traînage magnétique des ferromagnétiques en grains fins avec applications aux terres cuites Ann. Geophys. 1949, 5, 99-136
35. Song, Q.; Zhang, J. Z. Correlation between spin-orbital coupling and the superparamagnetic properties in magnetite and cobalt ferrite spinel nanocrystals J. Phys. Chem. B 2006, 110, 11205-11209 (Pubitemid 43999482)
36. Horoszewicz, J. S.; Leong, S. S.; Kawinski, E.; Karr, J. P.; Rosenthal, H.; Chu, T. M.; Mirand, E. A.; Murphy, G. P. LNCaP model of human prostatic carcinoma Cancer Res. 1983, 43, 1809-1818 (Pubitemid 13122588)
37. Kumar, M. V.; Tindall, D. J. Transcriptional regulation of the steroid receptor gene Prog. Nucleic Acids Res. Mol. Biol. 1998, 59, 289-306
38. Tevell, A.; Lennernas, H.; Jonsson, M.; Norlin, M.; Lennernas, B.; Bondesson, U.; Hedeland, M. Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry Drug Metab. Dispos. 2006, 34, 984-992 (Pubitemid 43763755)