Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry

Drug Metabolism and Disposition

Volumn 34, Issue 6, 2006, Pages 984-992

  Tevell, Annica ^a   Lennernäs, Hans ^a   Jönsson, Mats ^a,d   Norlin, Maria ^a   Lennernäs, Bo ^b   Bondesson, Ulf ^a,c   Hedeland, Mikael ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c NATIONAL VETERINARY INSTITUTE   (Sweden)

^d Pharmacy Callcenter   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYFLUTAMIDE; 4 NITRO 3 (TRIFLUOROMETHYL)ANILINE; ACETYLCYSTEINE; ANILINE; DRUG METABOLITE; FLUTAMIDE; GLUCURONIC ACID; HYDROXYL GROUP; SULFATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOG; DRUG CONJUGATION; DRUG HYDROXYLATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOMER; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS FRAGMENTOGRAPHY; MOLECULAR WEIGHT; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; SPECIES COMPARISON; SWINE; TANDEM MASS SPECTROMETRY; URINALYSIS;

ANDROGEN ANTAGONISTS; ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; DOGS; FLUTAMIDE; GLUCURONIDASE; HUMANS; MALE; MICROSOMES, LIVER; PROSTATE; PROSTATIC NEOPLASMS; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SWINE;

ANIMALIA; CANIS FAMILIARIS; SUS SCROFA;

EID: 33646792213     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.008516     Document Type: Article

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